Antigonadal and endocrine-disrupting activities of lambda cyhalothrin in female rats and its attenuation by taurine

Abstract

Lambda cyhalothrin (LCT) is a type II pyrethroid with a wide range of agricultural, industrial, and household uses. Taurine is a nonprotein sulfur containing amino acid as well as a well-known antioxidant and has valuable clinical applications in the detoxification of xenobiotics. The present study evaluated the effect of LCT on the reproductive and endocrine systems of female rats and determined whether taurine might alter these effects. Sexually mature female rats were administered LCT at two different dosages (6.3 mg/kg BW and 11.33 mg/kg BW) once daily by oral gavage for 14 consecutive days with the pretreatment of taurine (50 mg kg BW). LCT treatment resulted in diminished adrenal cholesterol, ovarian 3β- and 17β-hydroxysteroid dehydrogenase (HSD) activity with increased ovarian cholesterol, adrenal 3β- and 17β-HSD activity. Furthermore, protein and mRNA expressions of ovarian 17β-HSD and steroidogenic acute regulatory protein were also decreased. Hormonal imbalance was evident by concurrent reduction in the gonadotropic hormone, estradiol, and progesterone levels in LCT-treated rats. These rats also demonstrated the histopathological evidence of degenerative changes in the ovaries. Pretreatment of taurine attenuated the LCT-induced changes.

Updates on molecular and environmental determinants of luteal progesterone production

“…Despite the improved toxicity profile, pyrethroids also demonstrate EDC activity 151 . The synthetic pyrethroid lambda cyhalothrin was found to reduce serum progesterone levels, decrease ovarian Star and 17b-hsd expression, and diminish the activity of 17 β-HSD and 3 β-HSD in the rat ovary 152 . Fenvalerate, a synthetic pyrethroid insecticide, was also found to reduce basal progesterone production and Cyp11a1 expression in cultured GCs isolated from immature rat follicles 153 .…”

Widespread use of toxic agrochemicals and pesticides for agricultural products storage in Africa and developing countries: Possible panacea for ecotoxicology and health implications

“…In a study conducted by Rini Ghosh and his colleague [ 94 ], the endocrine-disrupting activities of Lambda-cyhalothrin in female rats were evaluated. Experimental animals administered with a dosage of 6.3–11.33 mg/kg BW daily for 14 days reported a significant decrease in adrenal cholesterol, with a corresponding decrease in ovarian 3β- and 17β-hydroxysteroid dehydrogenase activity, whereas an increase in ovarian cholesterol and a corresponding increase in adrenal 3β- and 17β-HSD activity were recorded.…”

“…Other hormonal imbalances, such as a worrisome reduction in estradiol and progesterone, were reported. Moreover, Gene expression data showed reduced expression of ovarian 17β-HSD and steroidogenic acute regulatory protein [ 94 ].…”

Nutritional Assessment of the Symptomatic Patient on a Plant-Based Diet: Seven Key Questions

“…[136,137] Taurine provides valuable xenobiotic detoxification and protects against degenerative endocrine hormone disruption. [138] Consequences of inadequate taurine intake or production include magnesium wasting, cardiomyopathy and arrhythmias, renal dysfunction, pancreatic beta cell dysfunction, plus numerous neurological and vision disorders including loss of retinal photoreceptors. Additional concerns with insufficiency include infertility, still births and neonatal developmental problems.…”