Antihemorrhagic Activity of Simple Compounds

Tishler, Max; Sampson, W. L.

doi:10.1021/ja01878a520

Cited by 17 publications

(6 citation statements)

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“…The first report was by Almquist (13), who apparently correlated the production of vitamin K potency by bacteria with Anderson's phthiocol from tubercle bacilli. Although other groups of investigators (14, 15, 181) failed in their early work to observe the great activity of this compound, they now agree that it is a t least twice as active as vitamin Ki (16,18,67,69,161,180,183,190). A very important observation was made by Ansbacher (29,31,72), who found that 2-methyl-l,4-naphthoquinone is more active than vitamin K1.…”

Section: Simple 14-~aphthoquinokes and Related Compoundsmentioning

confidence: 93%

“…A very important observation was made by Ansbacher (29, 31, 72), wrho found that 2-methyl-l ,4-naphthoquinone is more active than vitamin Ki. Although other groups of investigators (14,15,181) failed in their early work to observe the great activity of this compound, they now agree that it is at least twice as active as vitamin (16,18,67,69,161,180,183,190).…”

Section: Simple 14-naphthoquinones and Related Compoundsmentioning

confidence: 95%

“…Methyl-l,4-naphthoquinone (XIV)(18,29,61,67,72,134,170,180,181,183,190).................................................. 2.3-Dimethyl-l,4-naphthoquinone…”

mentioning

confidence: 99%

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Vitamin K.

Doisy¹,

Binkley²,

Thayer³

1941

Chem. Rev.

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Section: Simple 14-~aphthoquinokes and Related Compoundsmentioning

confidence: 93%

Section: Simple 14-naphthoquinones and Related Compoundsmentioning

confidence: 95%

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Vitamin K.

Doisy¹,

Binkley²,

Thayer³

1941

Chem. Rev.

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“…The naturally identified vitamin K molecules are vitamin K 1 , predominantly found in green vegetables, and vitamin K 2 synthesized by bacteria and found in fermented cheeses 9 –11 . The two most common synthetic derivatives developed are menadione (K 3 ), and the water soluble menadiol molecule, with conflicting published data on their potencies 12 –15 . Use of these agents in clinical practice has been confined to dietary supplements in chronically deficient patients, or to correct coagulopathies due to excess coumarin ingestion.…”

Section: Introductionmentioning

confidence: 99%

Phytomenadione or menadiol in the management of an elevated international normalized ratio (prothrombin time)

Green

Cairns

Harvey

et al. 2000

Aliment Pharmacol Ther

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Aim: To evaluate the efficacy of oral menadiol compared to intravenous phytomenadione when correcting coagulopathies associated with cholestasis. Methods: A total of 26 patients with cholestasis and an international normalized ratio (prothrombin time) greater than 1.2, were randomized to receive either 20 mg o.d. for 3 days of oral menadiol (n=12), or 10 mg o.d. of intravenous phytomenadione (n=14) prior to endoscopic retrograde cholangeopancreatography. Liver function tests and international normalized ratio were measured daily for 3 days. Results: Liver function tests and international normalized ratio were comparable between groups at entry into the study (P > 0.05), but serum albumin was significantly lower in the intravenous phytomenadione group following treatment (P < 0.05). A decrease in international normalized ratio occurred in both groups following administration of vitamin K (P < 0.05). Two patients in the intravenous group required fresh frozen plasma, as failure to normalize international normalized ratio was observed. No adverse drug reactions were observed in either group, and no patient required re‐admission for bleeding during a 4‐week follow‐up period after cholangeopancreatography. Conclusion: Oral menadiol appears to be an effective alternative to intravenous phytomenadione in the correction of coagulopathies associated with obstructive liver disease. This simplifies the care of patients with deranged clotting times requiring cholangeopancreatography, particularly those to be managed as out‐patients.

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“…L'intérêt de ces 2 corps réside dans le fait qu'ils sont voisins de la vitamine K par leurs propriétés physiques et chimiques et qu'ils présentent, comme elle, un pouvoir antihémorragique (14,15,16,17,18,19).…”

unclassified

Contribution a l’étude de quelques mycobactéries: metabolites et antibiotiques

Odier¹

1949

Pathobiology

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Antihemorrhagic Activity of Simple Compounds

Cited by 17 publications

References 0 publications

Vitamin K.

Vitamin K.

Phytomenadione or menadiol in the management of an elevated international normalized ratio (prothrombin time)

Contribution a l’étude de quelques mycobactéries: metabolites et antibiotiques

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