Antihormonal potential of selected D-homo and D-seco estratriene derivatives

Mechanism of antiproliferative action of a new d -secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility

“…Especially that C14 -C17 are cavity vertices with a favorable interaction, and that the C15-C16-C17 crescent should be at the appropriate position, and therefore that the fragmentation of the D-ring in secoestradiol derivatives may lead to a decrease or total loss of affinity for estrogen-receptor [58]. Additionally, observations by Jovanovic-Santa et al confirmed that numerous newly synthetized and investigated D-secoestrogen derivatives undergo a totally loss of estrogen activity [17][18][19]59].…”

“…The majority of published studies have focused on substitutions in multiple positions of the steroid structure or ring modifications. Several sets of newly synthetized secoestrones have been reported which include modifications to avoid estrogenic activity through opening of their D-ring [17][18][19]. Our previous studies demonstrated that some D-secoestrone derivatives exert pronounced antiproliferative activity thanks to their influence on microtubule formation from tubulin dimers [20].…”

Preliminary Phytochemical Screening of wild edible fruits from Boda and Kolli hills

“…Steroids are cholesterol derived lipophilic group it is important secondary metabolites. The presence of steroids used in antihormones (Jovanovic et al, 2015), contraceptive drugs (Lopez et al, 2006), anticancer agents (Thao et al, 2015), cardiovascular agents (Rattanasopa et al, 2015), osteoporosis drugs (Hoppé et al, 2011), antibiotics, anesthetics, anti-inflammatory, and antiasthmatics (Aav et al, 2005). M. koenigii, P. loureiroi, F. religiosa, H. mystax, P. emblica, S. cumini, Z. mauritiana, and Z. oenoplia shows the presence of terpenoids.…”

Effect of some Micro-Elements on Steroids Production from Embryogenic Callus of in vitro Date Palm Sakkoty and Bartamuda Cultivars

“…Steroids family plays an important role in the biochemistry and composition of organisms [3]. Steroids are used as anti-cancer agents, antibiotics, and antiinflammatory, and anti-hormones drugs [4]. First study for the steroids production in date palm tissues was documented by El Sharbasy et al, [5] who found that total steroids in tow Egyptian cultivars tissues demonstrated higher values in pollen grain and shoot tip of in vivo tissues, and also in leaf and roots of the in vitro tissues.…”