Antihypercholesterolaemic and antioxidant activity assessment of some plants used as remedy in Turkish folk medicine

Avcı, Gülcan; Küpeli, Esra; Eryavuz, Abdullah; Yeşilada, Erdem; Küçükkurt, İ̇smail

doi:10.1016/j.jep.2006.03.032

Cited by 80 publications

(65 citation statements)

References 22 publications

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“…Mistletoe contains numerous bioactive compounds, including lectins, alkaloids, viscotoxins, and polysaccharides (Khwaja et al 1980(Khwaja et al , 1986Holtskog et al 1988), and their biological effects are known to be changed according to their preparation, host trees, and harvest times (Hulsen & Mechelke 1982;Park et al 1999). Previous reports showed the beneficial effects of mistletoe on blood cholesterol levels using methanol or ethanol mistletoe extracts (Avci et al 2006;Ferrero et al 2007;Bachhav et al 2012); however, an aqueous extract of mistletoe was used in this study. Thus, the different effects of mistletoe extracts on plasma cholesterol levels between our study and previous reports may be caused by different extract preparations which may lead to a different composition of bioactive compounds.…”

Section: Discussionmentioning

confidence: 94%

“…Methanol or ethanol extracts of mistletoe were reported to decrease total plasma cholesterol levels (Avci et al 2006;Ferrero et al 2007;Bachhav et al 2012) and increase HDL-C levels (Avci et al 2006;Ben et al 2006;Adaramoye et al 2012) in mice or rats. However, the effect of an aqueous extract of Korean mistletoe on the plasma levels of cholesterol and HDL-C was controversial (Kim 2006;Kim & Kim 2009).…”

Section: Kme Decreases Muscle Fatigue In Exercise-trained Micementioning

confidence: 99%

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The effects of Korean mistletoe extract on endurance during exercise in mice

Lee

Kim

et al. 2014

Animal Cells and Systems

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Many investigators have screened drugs and foods for the enhancement of endurance capacity and antifatigue. Mistletoe, a semiparasitic plant on various deciduous trees, has many known biological activities, including anticancer, anti-diabetes, antioxidant, and anti-cardiovascular disease effects. In a previous study, Korean mistletoe extract (KME) was reported to increase endurance capacity in mice. However, whether the administration of KME further enhances exercise performance, when combined with exercise training, was not investigated. In this study, we demonstrate that the administration of KME decreases the level of plasma lactate dehydrogenase, parameter of tissue damage and muscle fatigue when combined with exercise training. Exercise training increases the muscular glycogen and plasma free fatty acid (FFA) level, and KME administration in sedentary mouse group increases the plasma FFA level, indicating that KME administration alters the energy resources in muscle. In addition, KME administration enhances the exercise performance in sedentary mouse group, but did not further enhance exercise performance when combined with exercise training, suggesting that KME could be an excellent mimetic of exercise.

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Section: Discussionmentioning

confidence: 94%

Section: Kme Decreases Muscle Fatigue In Exercise-trained Micementioning

confidence: 99%

The effects of Korean mistletoe extract on endurance during exercise in mice

Lee

Kim

et al. 2014

Animal Cells and Systems

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“…In addition, steroid hormones, bile acids, and vitamin D are synthesized from cholesterol (Hanukoglu, 1992). High level of serum cholesterol is associated with the increased risk of atherosclerosis and cardiovascular diseases, mainly due to the oxidation of LDL; the major transporter of cholesterol in blood (Avci et al, 2006). LDL delivers cholesterol to the tissues such as artery walls and therefore drives atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Lamium album or Urtica dioica? Which is more effective in decreasing serum glucose, lipid and hepatic enzymes in streptozotocin induced diabetic rats: A comparative study

Mehran¹,

Norasfard²,

Abedinzade³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Objectives: Diabetes mellitus, the most common endocrine disorder, is defined by hyperglycaemia. Urtica dioica or stinging nettle is known to have antidiabetic effects. Lamium album or non stinging nettle is shown to have some beneficial effects such as antioxidant, and cytoprotective properties. The purpose of this study was to compare the effects of hydroalchoholic extract of L. album and U. dioica on serum glucose, lipids and hepatic enzymes level in sterptozotocin induced diabetic rats. Methods: Thirty-two male Wistar rats were randomly assigned into four groups; normal control, diabetic control, diabetic treated with U. dioica (100 mg/kg/daily), diabetic treated with L. album (100 mg/kg/daily) for 28 days. Serum glucose, cholesterol, triglyceride (TG), alanin trasaminase (ALT), alkaline phosphatase (ALP) and aspartate transaminase (AST) were measured. Results: U. dioica and L. album extracts caused significant decrease (p<0.05) in serum glucose level in diabetic rats. Compared to diabetic control, both extracts significantly decreased serum cholesterol, ALT, AST and ALP (p<0.05). The level of serum TG in diabetic rats treated with U. dioica was significantly lower than that of animals treated with L. album (p<0.05). Conclusion: it seems that administration of U. dioica and L. album extracts in diabetic rats may have similar lowering effects on the level of serum glucose, cholesterol and hepatic enzymes, albeit U. dioica might be more effective in improving serum TG as compared with L. album.

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“…Also, there is considerable evidence that Thyme presents positive effects with increasing concentrations without leading to any genetic damage in human blood cells. Avci et al (2006) have reported that T. spicata had antihypercholesterolaemic and antioxidant activities. Likewise Dorman et al (2004) found antioxidant properties of aqueous T. spicata extracts (Dorman et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Modulatory effects of Thymbra spicata L. different extracts against the mercury induced genotoxicity in human lymphocytes in vitro

2011

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Mercury, a xenobiotic metal, is a highly deleterious environmental pollutant. Moreover, in any form mercury is reported to be toxic. On the other hand, Thymbra spicata L., a member of the Lamiaceae family, has long been investigated popularly of biological roles; mainly antimicrobial and antioxidant activities. However, there are very scarce data on the cytogenetic effects of thyme species. The purpose of this study was to investigate the genetic safety of different extracts from T. spicata (water extract, methanol extract, and ethanol extract) and the effects of T. spicata on mercury (as HgCl 2 ) induced genotoxicity. Sister chromatid exchange (SCE) and micronucleus (MN) assays were performed to assess DNA damages in cultured human lymphocytes (n = 5). Our results clearly revealed that, the SCE and MN rates induced by HgCl 2 were alleviated by the presence of T. spicata. As conclusion, this study demonstrated for the first time that the T. spicata provided increased resistance of DNA against HgCl 2 induced genetic damage in human lymphocytes. Based on the results of this study, it may be concluded that the T. spicata is a nontoxic material that could be used as a suppressor of heavy metal-induced genotoxicity.

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Antihypercholesterolaemic and antioxidant activity assessment of some plants used as remedy in Turkish folk medicine

Cited by 80 publications

References 22 publications

The effects of Korean mistletoe extract on endurance during exercise in mice

The effects of Korean mistletoe extract on endurance during exercise in mice

Lamium album or Urtica dioica? Which is more effective in decreasing serum glucose, lipid and hepatic enzymes in streptozotocin induced diabetic rats: A comparative study

Modulatory effects of Thymbra spicata L. different extracts against the mercury induced genotoxicity in human lymphocytes in vitro

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