Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet‐Induced Hypercholesterolemia

Abstract

The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, 1H and 13C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause.

Chaetomorpha linum polysaccharides alleviate NAFLD in mice by enhancing the PPARα/CPT-1/MCAD signaling

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Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prunífera against Triton WR-1339 and hyperlipidemic diet in mice

“…Moreover, these higher plasma TG levels have been attributed mainly to an increased population of small, dense LDL deposits which are very atherogenic and enhanced cholesteryl ester mass transfer from apolipoprotein B-containing lipoproteins (VLDL and LDL). TGs have also been proposed to be a major determinant of cholesterol esterification, its transfer and HDL remodeling in human plasma (Paim et al, 2017).…”

Potencial hipocolesterolêmico e antioxidante da folha de Taioba (Xanthosoma sagittifolium (L.) Schott ) em camundongos dislipidêmicos induzidos por dieta

“…A escolha da linhagem animal se deu pela facilidade de manuseio, menor custo e também porque estudos recentes mostraram a capacidade de aumentar o colesterol quando estes camundongos foram submetidos a dieta hipercolesterolêmica (Brant et al, 2014;ilavenil et al, 2017;Paim et al, 2017) que este modelo animal pode ser viável em experimentos com dislipidemia.…”