Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats

Abstract

The present study evaluates the efficacy of ethanolic extract of Boerhaavia diffusa L (BD) administered orally at a dose of 500mg/kg body weight for a period of 30 days to alloxanized diabetic rats and its efficacy compared with the standard hypoglycaemic drug metformin. Diabetic animals showed glycemic dysregulation, altered ionic balance, increased levels of serum markers of kidney function, and reduced Na+-K+ ATPase activity and endogenous antioxidant status. Administration of BD not only maintained the ionic balance and renal Na+-K+ ATPase activity but also significantly minimized diabetic hyperglycaemia. The renal antioxidant status (GPx, Catalase, SOD and GSH) remained in the near normal range and LPO level lower than the non-diabetic level. These effects are comparable to the changes brought about by metformin treatment and even better. Over all, the present study provides evidence for BD to be a potent renoprotective and antihyperglycaemic agent in diabetic animals.

Role of medicinal plants in the management of diabetes mellitus: a review

“…Oral administration of aqueous extract of O. sanctum (O. tenuiflorum) mixed with diet for 8 weeks showed a significant reduction in fasting blood glucose, lipid peroxidation products, serum lipid profile and improvement in glucose tolerance (Hussain et al 2001). In a study carried out by Hannan et al 2006, ethanol, butanol Anti-diabetic Pari and Satheesh (2004) and Singh et al (2011) 15 Ankolekar et al (2011) and Abeywickrama et al (2011) and Satoh et al (2015) 19 Bavarva and Narasimhacharya (2008) and Eliza et al (2009) 27 Curcuma longa Hypoglycemic, antidyslipidemic Sachdewa and Khemani (2003) and Kumar et al (2013) 37 Ipomoea batatas Anti-hyperglycemic, antihyperlipidemic Deguchi and Miyazaki (2010) and Huang et al (2011) 56 Arul et al (2004) and Khan et al (2013) Xue et al (2007) and Kumar et al (2012) 67 Urtica dioica antioxidant effects in cholesterol-fed rabbits (Gupta et al 2006).…”

Mechanisms of Herbal Nephroprotection in diabetes mellitus

“…integrin-linked kinase, EMT, MMP-9/TIMP-1 ratio [127] ( 10 Journal of Diabetes Research 12 Journal of Diabetes Research ↓: decreased/prevented the increase (of activity (for enzymes)/level (for biochemical parameters))/inhibited/inactivated/blocked/suppressed/downregulated (about pathways, enzymes, receptors, cytokines, etc. ); ↑: increased/prevented the decrease (of activity (for enzymes)/level (for biochemical parameters))/stimulated/activated/upregulated; →: [172], Chlorella pyrenoidosa [173], Cladophora glomerata [34], Coccinia indica [111], coconut water [61], Cordyceps militaris [114], Cornus officinalis [47], curcumin [79], dihydroquercetin [48], Dioscorea bulbifera [96], diosgenin [62], ellagic acid [37], emodin § [94], Flammulina velutipes [53], Fragaria × ananassa [89], Huangqi decoction [36], Hypericum perforatum [31], Paederia foetida [78], Paeonia emodi [63], palm oil and rice bran oil [50], Panax notoginseng [35], Panax quinquefolium [82], Panax quinquefolium [83], Physalis angulata [64], Pleurotus eryngii polysaccharides [57], Prunella vulgaris [84], Punica granatum [32], quercetin [49], Ramulus mori [77], Rheum ribes [175], secoisolariciresinol diglucoside [88], Spirogyra neglecta [176], Tangke decoction [116], Terminalia chebula [33] Insulin resistance…”

“…Continued. Boerhaavia diffusa[172], breviscapine[51], Coccinia indica[111], coconut water[61], curcumin[108], d-pinitol[2], ellagic acid[37],…”

Identification of Phytoconstituents using GC-MS and Determination of Antimicrobial and Antimycobacterial Activity of Boerhaavia diffusa L. Leaves

“…Pharmacological studies have reported in Boerhaavia diffusa as anticonvulsant [12], cardioprotective [13], anti-inflammatory [14], antidiabetic [15], anti-arthritic [16], hepatoprotective [17], anxiolytic activity.18…”