Antihyperglycaemic Effect of Tetracarpidium Conophorum Nuts in Alloxan Induced Diabetic Female Albino Rats

Abstract

The antihyperglycaemic activity of Tetracarpidium conophorum nut (walnut) was investigated in albino rats. A total of 20 albino rats were used for the study. The rats were divided into five groups (A–E) of four rats each. Diabetes were induced in the rats except four which served as the positive control group A. Groups B (negative control), C, D, and E contain diabetic rats each with blood sugar level ≥17.00 mmol/L. Groups A and B were fed on 85.2 g of top feed grower over the test period. Test groups C, D, and E were fed on 21.3 g, 42.6 g, and 85.2 g of walnuts, respectively, and their fasting blood sugar (FBS) levels were checked on daily basis. Fasting blood glucose levels of the test groups were significantly lower than negative control P < 0.05, for 3rd, 7th, and 10th days of the test. There were also significant increase in the body weight and hemoglobin concentration and a decreased urine output of the test group compared with the controls. These results indicate that Tetracarpidium conophorum nut (walnut) has an antihyperglycemic effect in diabetic rats.

Antidiabetic, antihyperlipidemic activities and herb–drug interaction of a polyherbal formulation in streptozotocin induced diabetic rats

“…In the present study, increased urine output was observed in diabetic control animals which are in line with previously published report [15] . Treatment with OJ, Metformin and OJ-Metformin combination caused significant reduction in urine output.…”

<i>Tetracarpidium conophorum</i> (African walnut) Hutch. & Dalziel: Ethnomedicinal uses and its therapeutic activities

“…Similar alterations in the serum lipid of the animals suggested cardiovascular risk and that it was not completely safe for consumption. Onwuli, Bown and Ozoani (2014) and Ogunyinka et al (2015) reported that the nuts have the potential to reduce hyperglycaemia; the authors also reported that the nuts increased the haemoglobin level and decreased urine output in the test group when compared with controls and could prevent diabetes associated with renal damage.…”

Functional Foods and Bioactive Compounds: A Review of Its Possible Role on Weight Management and Obesity’s Metabolic Consequences

“…The consumption of 85.2 g of walnuts from 40 male rats with increased blood glucose level for 2 weeks reduced the blood glucose levels [21]. In a randomized control trial for 12 weeks the consumption of 30 g/day of cashew nuts from 300 adults with type II diabetes, increased HDL cholesterol, body weight, BMI, waist circumference, and decreased systolic blood pressure [76].…”