Antihyperglycemic Activity of Aqueous Extract of Euphorbia guyoniana in
Streptozotocin-Induced Diabetic Rats

Amssayef, Ayoub; Azzaoui, Bouchra; Bouadid, Ismail; Eddouks, Mohamed

doi:10.2174/1871529x21666211214161639

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…E. prunastri extract showed antioxidant activity and proved richness in phenolic acids and flavonoids. 72 …”

Section: Pharmacological Activities Of Lichensmentioning

confidence: 99%

Lichens in Pharmacological Action: What Happened in the Last Decade?

Karagöz¹,

Karagoz²

2023

Eurasian J Med

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Lichens are a unique group of organisms, which can produce compounds that are named secondary metabolites and rarely or are not produced in other organisms. Lichens possess pharmacological actions related to their secondary metabolites. Our knowledge of lichens and their pharmacological actions rapidly increases as new technologies and devices, which facilitate the investigation of the chemical profile and biological activities of lichens, are introduced and become more readily available. In addition, new methods and perspectives, as well as suggestions for pharmacological mechanisms, accumulate daily. Furthermore, lichen substances stand as a relatively untapped source of natural products. Accordingly, researchers investigate the pharmacological actions of lichen-derived material more frequently than it was in the past. This review focused on the pharmacological activities of lichens published in the last 11 years (2012-2022). Literature data obtained from WebOfScience and PubMed databases using related search keywords revealed that anti-genotoxicity, anti-cancer, and anti-microbial activity studies have constantly been conducted. More recently, immunomodulatory and inflammation-related studies took to the stage. Enzyme inhibition actions were popular as well. Our selection was based on the novelty and mechanistic insight that papers presented.

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“…E. prunastri extract showed antioxidant activity and proved richness in phenolic acids and flavonoids. 72 …”

Section: Pharmacological Activities Of Lichensmentioning

confidence: 99%

Lichens in Pharmacological Action: What Happened in the Last Decade?

Karagöz¹,

Karagoz²

2023

Eurasian J Med

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“…However, to the best of our knowledge, only a few scientific studies dealt with the medical importance of the aerial part of this plant and its bioactive constituents responsible for its folk use. The aerial part of E. guyoniana was reported to exert antimicrobial [ 5, 6, 7, 8 ], antifungal [ 9 ], cytotoxic [ 7, 10 ], antioxidant [ 10, 11 ] and antihyperglycemic [ 12 ] activities. Phytochemical studies on the aerial part of E. guyoniana revealed the presence of jatrophane diterpenes [ 10, 13 ], polyester diterpenes [ 14 ], flavonoids [ 11, 15 ] and an alkaloid [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Green microwave-assisted extraction ofEuphorbia guyoniana:Optimization, metabolite profile andin vivoanti-inflammatory potential

Issaadi,

Bachir,

Naama

et al. 2024

Preprint

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This study aimed to optimize microwave-assisted extraction of phenolic compounds from undervalued traditional plant Euphorbia guyoniana (Boiss. & Reut.) using central composite design of response surface methodology. The independent variables were extraction time (x1: 5 - 25 min), ethanol concentration in the extractive solvent (x2: 30 - 70%), microwave power (x3: 180 - 800 Watt) and feed-to-solvent ratio (x4: 1:7.5 - 1:17.5) while dependent variables were total phenolic content (TPC) and total flavonoid content (TFC). Extract obtained by using the optimal extraction parameters was evaluated for its in vivo anti-inflammatory activity by the carrageenan-induced paw edema model and was subjected to RP-HPLC-PDA-ESI-MS analysis to investigate the presence of phenolic compounds. The optimal conditions for highest TPC (377.22 +/- 5.42 mg GAE/100g) and TFC (184.40 +/- 1.18 mg QE/100g) were obtained at extraction time of 25 min, ethanol concentration of 40.57%, microwave power of 450 Watt and feed-to-solvent ratio of 1:17.5. The quadratic models significantly (p < 0.0001) fitted the experimental data with R2 values of 0.984 and 0.970 for TPC and TFC, respectively. Optimal extract of Euphorbia guyoniana significantly higher inhibited carrageenan induced inflammation with a concentration of 50 mg/kg (75,98%) when compared with reference anti-inflammatory drug ibuprofen (43,77%). Finally, above the previously reported phenolic constituents, i.e, quercetin and kaempferol derivatives, hydroxycinnamates have been identified for the first time in Euphorbia guyoniana plant extract.

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Antidiabetic and Antidyslipidemic Effects of Artemisia mesatlantica, an Endemic Plant from Morocco

Qabouche,

Amssayef,

Bouadid

et al. 2023

CHDDT

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Aims: The study aimed to assess the antihyperglycemic and antidyslipidemic activities of Artemisia mesatlantica. Background: Artemisia mesatlantica is an endemic plant of Morocco used in traditional medicine as an alternative treatment for diabetes. Objective: The study was designed to examine the antihyperglycemic and antidyslipidemicability of aqueous extract of Artemisia mesatlantica (AMAE) in experimental animal models. Methods: The effect of the single and repeated oral administration (7 days of treatment) of AMAE (60 mg/kg) on blood glucose and lipid profile were assessed in normal and streptozotocin-induced diabetic rats. Furthermore, to confirm the antidyslipidemic effect of Artemisia mesatlantica, a model of hyperlipidemia induced by tyloxapol (Triton WR-1339) in rats was used. Results: The AMAE (60 mg/kg) was able to significantly reduce glycaemia, improve lipid profile and increase hepatic glycogen content in STZ-induced diabetic rats. In addition, pretreatment of rats for 7 consecutive days with an aqueous extract of Artemisia mesatlantica (600 mg/kg) prior to tyloxapol injection prevented increases in plasma levels of total cholesterol, triglycerides and LDL-c. Conclusion: From these observed results, it can be deduced that Artemisia mesatlantica possesses remarkable antidiabetic and antihyperlipidemic properties.

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Antihyperglycemic Activity of Aqueous Extract of Euphorbia guyoniana in Streptozotocin-Induced Diabetic Rats

Cited by 3 publications

References 30 publications

Lichens in Pharmacological Action: What Happened in the Last Decade?

Lichens in Pharmacological Action: What Happened in the Last Decade?

Green microwave-assisted extraction ofEuphorbia guyoniana:Optimization, metabolite profile andin vivoanti-inflammatory potential

Antidiabetic and Antidyslipidemic Effects of Artemisia mesatlantica, an Endemic Plant from Morocco

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