Antihyperglycemic activity of Caralluma attenuata

Venkatesh, Sama; Reddy, G. Dayanand; Reddy, B. Madhava; Ramesh, M.; Rao, A. S.

doi:10.1016/s0367-326x(03)00021-2

Cited by 166 publications

(107 citation statements)

References 5 publications

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“…The mechanism of the hypoglycemic action of coumarins may be involved in hepatotoxicity [71]. The terpene trans-dehydrocrotonin (Figure 2B), which is classified as a lactone-type clerodane diterpene, showed antidiabetic activity in mice [72][73][74].…”

Section: Terpenesmentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Section: Terpenesmentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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“…The herbal drugs are prescribed widely because of their effectiveness, fewer side effects and relatively low cost and the traditional plant medicines are used throughout the world for a range of diabetic presentations [5] . Citrullus colocynthis (Cucurbitaceae) (C. colocynthis), commonly known as "bitter apple", "colosynth", "vine-of-sodom" and "tumba" is a well-known fruit traditionally used as an antidiabetic medication in the Mediterranean countries [6] .…”

Section: Introductionmentioning

confidence: 99%

Effects of hydro-ethanol extract of Citrullus colocynthis on blood glucose levels and pathology of organs in alloxan-induced diabetic rats

Oryan

Hashemnia

Hamidi

et al. 2014

Asian Pacific Journal of Tropical Disease

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“…22 Although streptozotocin is one of the most commonly used for induction of diabetes but it reported to have some disadvantages such as irreversible damage of the pancreatic β-cells, alloxan-induced diabetic model is preferable in recent years due to less toxicity and reversible damage of pancreas. 2,3,4 For inducing diabetes in experimental animals, use of a low dose of alloxan 23,24 has been reported earlier. A slide overdosing is highly toxic and may cause the loss of experimental animals.…”

Section: Resultsmentioning

confidence: 99%

Evaluation and Optimization of Effective-dose of Alloxan for Inducing Type-2 Diabetes Mellitus in Long Evans Rat

Rahman¹,

Yasmin²,

Rahman³

et al. 2017

IJPER

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Background:The optimal effective and safe dose of alloxan for inducing stable diabetes in rats has been long arguable. Lower doses can result in auto-reversion from diabetogenic state to normal state. On the other hand, higher doses cause toxicity and loss of experimental animals since it completely destroys the insulin-producing pancreatic β cells. Therefore, determination of effective as well as safe dose of alloxan to induce stable diabetes in experimental Long Evan rats is crucial for investigating on diabetes. Objective: To determine effective and safe dose of alloxan for inducing a stable diabetes mellitus in Long Evans Rats to facilitate availability of diabetic rats for studying on diabetes. Methods: Healthy adult Long Evans rats (80-156 g) were divided into eight groups and each group contains six rats. One group treated as a nondiabetic control (C) while the other seven groups (Group-2 to Group-8) were used as experimental diabetic groups. Different doses of alloxan (80, 100, 120, 130, 140, 150 and 160 mg/kg body weight) were injected through intraperitoneal routes in overnight fasting group-2 to group-8 rats respectively. Blood glucose levels were monitored before and after administering alloaxan dose (for 7 consecutive weeks) by using a blood glucose meter and test strips. Results: In the case of non-diabetic rats, the normal blood glucose levels were found between 7.75 to 10.8 mmol/L. On the other hand, a slow gradual increment of blood glucose levels were measured among the rats (group-2, group-3 and group-4) treated with low doses of alloxan (80, 100 and 120 mg/kg BW) until 5 weeks. However, the increased blood glucose levels were reverted back to its normal by the following two weeks. Group-5 and Group-6 rats treated with alloxan doses of 130 mg/kg and 140 mg/kg respectively stably increased blood glucose levels during the experimental periods. While rats in group-7 and group-8 (treated with 150 and 160 mg/kg BW) were expired by the experimental period might be due to severe alloxan toxicity. Group-6 rats treated with 140 mg/kg alloxan were more preferable because the diabetic level is much more stable and significant than group-5. Conclusion: The optimum effective dose of alloxan was found to be 140 mg/kg BW for induction of stable diabetes in Long Evan rats.

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Antihyperglycemic activity of Caralluma attenuata

Cited by 166 publications

References 5 publications

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Effects of hydro-ethanol extract of Citrullus colocynthis on blood glucose levels and pathology of organs in alloxan-induced diabetic rats

Evaluation and Optimization of Effective-dose of Alloxan for Inducing Type-2 Diabetes Mellitus in Long Evans Rat

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