Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats

Zhang, Yonghui; Cai, Jiyang; Ruan, Han‐Li; Pi, Hui‐Fang; Wu, Jizhou

doi:10.1016/j.jep.2007.05.022

Cited by 100 publications

(63 citation statements)

References 7 publications

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“…Kinsennoside from A. roxburghii showed a significant hypoglycemic effect in streptozotocin‐induced diabetic rats. It ameliorated β‐cells’ damage caused by oxidative stress and NO, and also prevented weight loss in the diabetic animals (Zhang et al., 2007). In the study by Jian‐Gang Zhang (2015), polysaccharose isolated from A. roxburghii exerted antioxidant effect on diabetic mice leading to an improvement of glucose and lipid metabolism, an increase in immune protection, and a decrease in oxidative stress, which might contribute to its antidiabetic effect (Zhang et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported that kinsenoside isolated from Anoectochilus roxburghii and Anoectochilus formosan us provide beneficial effects on hepatoprotective (Wang et al., 2005), antihyperlipolysis activities (Du et al., 2001). It also reduces blood glucose (Zhang, Cai, Ruan, Pi, & Wu, 2007; Zhang, Liu, Liu, Li, & Yi, 2015), modulaties the allergic response, and exerts anti‐inflammation in both the LPS‐induced inflammation in macrophages and endotoxin‐shocked mice (Hsiao, Wu, Lin, & Lin, 2011). …”

Section: Introductionmentioning

confidence: 99%

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Anti‐inflammatory and anti‐insulin resistance activities of aqueous extract from Anoectochilus burmannicus

Budluang

Pitchakarn

Ting

et al. 2016

Food Science & Nutrition

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This study investigated biological activities including antioxidative stress, anti‐inflammation, and anti‐insulin resistance of Anoectochilus burmannicus aqueous extract (ABE). The results showed abilities of ABE to scavenging DPPH and ABTS free radicals in a dose‐dependent manner. Besides, ABE significantly reduced nitric oxide (NO) production in the lipopolysaccharide (LPS)‐treated RAW 264.7 via inhibition of mRNA and protein expressions of nitric oxide synthase (iNOS). The LPS‐induced mRNA expressions of cyclooxygenase‐2 (COX‐2) and interleukin 1β (IL‐1β) were suppressed by ABE. Moreover, ABE exerted anti‐insulin resistance activity as it significantly improved the glucose uptake in tumor necrosis factor (TNF)‐α treated 3T3‐L1 adipocytes. In addition, ABE at the concentration of up to 200 μg/mL was not toxic to human peripheral blood mononuclear cells (PBMCs) and did not induce mutations. Finally, the results of our study suggest the potential use of A. burmannicus as anti‐inflammatory, anti‐insulin resistance agents, or food supplement for prevention of chronic diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory and anti‐insulin resistance activities of aqueous extract from Anoectochilus burmannicus

Budluang

Pitchakarn

Ting

et al. 2016

Food Science & Nutrition

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“…Whereas STZ induced nitrite generation in pancreas ß-cells, was attenuated by FG. Much evidence supports the hypothesis that high-output NO by iNOS provokes deleterious consequences in inflammatory diseases (3)(4)(5)23). The ability of FG to attenuate STZ-induced ß-cell damage was demonstrated by modulating the activity of immune response.…”

Section: Discussionmentioning

confidence: 67%

“…The mechanism underlying ß-cell destruction is not clear (2). In the STZ-induced diabetic model, hyperglycemia arises from the irreversible destruction of pancreatic ß-cells through free radicals and nitric oxide (NO), causing degranulation and reduction of insulin secretion (3). Many effects of STZ on pancreatic islets are similar to those exerted by interleukin-1ß (IL-1ß) and some studies indicate that IL-1ß-induced islet injury as well as STZ-induced islet cytotoxicity are mediated by NO production (4,5).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of fermented ginseng on streptozotocin-induced pancreatic β-cell damage through inhibition of NF-κB

Yuan

Chung²

2009

Int J Mol Med

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Abstract. Ginseng (Panax ginseng C.A. Meyer) is widely used in Asian countries as a traditional medicine for the treatment of various diseases. It is known to have anti-inflammatory effects, although the mechanism is not clear. In this study, preventive effects of fermented ginseng (FG) against streptozotocin (STZ)-induced pancreatic ß-cell death was assessed in RINm5F insulinoma cells. FG markedly inhibited the production of nitrite in a dose-dependent manner. The decrease in nitrite production was found to correlate with reduced inducible nitric oxide (iNOS) protein and mRNA levels. To characterize the anti-inflammatory mechanism of FG at the transcriptional level, we examined effects of FG on the activity of nuclear factor-κB (NF-κB). FG reduced a translocation of the NF-κB subunit and NF-κB-dependent transcriptional activity. FG blocked signaling upstream of NF-κB activation, such as degradation of inhibitor factor-κB· (IκB·) and phosphorylations of extracellular signalregulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK). These results suggest that FG protects against STZ-induced pancreatic ß-cell damage by downregulation of iNOS, cyclooxygenase-2 (COX-2), and tumor necrosis factor-· (TNF-·) gene expressions by blocking NF-κB and mitogen-activated protein kinase activities.

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“…Kinsenosides were first isolated from A. koshunensis by Ito et al (1993) and shown to have antihyperliposis and antihyperglycemic effects (Du et al, 2001;Zhang et al, 2007). Orchids also have a unique mycorrhizal relationship (Bernard, 1902).…”

Section: Introductionmentioning

confidence: 99%

Promoting role of an endophyte on the growth and contents of kinsenosides and flavonoids of Anoectochilus formosanus Hayata, a rare and threatened medicinal Orchidaceae plant

Zhang

Zhao

et al. 2013

J. Zhejiang Univ. Sci. B

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Anoectochilus formosanus, commonly known as "Jewel Orchid", is a Chinese folk medicine used to treat hypertension, diabetes, and heart disease. The existence of A. formosanus is currently threatened by habitat loss, human and animal consumption, etc. The highly potent medicinal activity of A. formosanus is due to its secondary metabolites, especially kinsenosides and flavonoids. This orchid also has a unique mycorrhizal relationship. Most adult orchids rely on endophytes for mineral nutrition and have complex interactions with them, which are related to plant growth, yield and changes in secondary metabolites. This study investigated the promoting role of F-23 fungus (genus Mycena) on the biomass and contents of kinsenosides and flavonoids of A. formosanus in pot culture. The following were observed after 10 weeks of symbiotic cultivation: increased shoot height, shoot dry weight, and leaf numbers by 16.6%, 31.3%, and 22.5%, respectively; increased contents of kinsenosides, isorhamnetin-3-O-β-D-rutinoside, and isorhamnetin-3-O-β-D-glucopyranoside by 85.5%, 226.1%, and 196.0%, respectively; some hyphae in epidermal cells dyed red and/or reddish brown by safranine; and, significantly reduced number of starch grains in cortical cells. Moreover, F-23 fungus significantly improved the kinsenoside and flavonoid contents of A. formosanus. These findings supported the reports that endophytes can alter the production of secondary metabolites in their plant hosts, although further physiological, genetic and ecological analyses are warranted.

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Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats

Cited by 100 publications

References 7 publications

Anti‐inflammatory and anti‐insulin resistance activities of aqueous extract from Anoectochilus burmannicus

Anti‐inflammatory and anti‐insulin resistance activities of aqueous extract from Anoectochilus burmannicus

Protective effects of fermented ginseng on streptozotocin-induced pancreatic β-cell damage through inhibition of NF-κB

Promoting role of an endophyte on the growth and contents of kinsenosides and flavonoids of Anoectochilus formosanus Hayata, a rare and threatened medicinal Orchidaceae plant

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