Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats

Javrushyan, Hayarpi; Nadiryan, Edita; Grigoryan, Anna; Avtandilyan, Nikolay; Maloyan, Alina

doi:10.1016/j.yexmp.2022.104763

Cited by 13 publications

(6 citation statements)

References 64 publications

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“…In the future, advancing knowledge on the ability of simple dipeptides to form supramolecular hydrophilic channels may assist their design for insertion into biological membranes, for instance, towards therapeutic effects [47][48][49]. Further scope for applications of Nva-bearing dipeptides may also arise as current studies are revealing new beneficial effects from the administration of this amino acid in diverse pathological settings, spanning from neurodegeneration to hypertension [50][51][52][53][54].…”

Section: Discussionmentioning

confidence: 99%

Self-Assembly and Gelation Study of Dipeptide Isomers with Norvaline and Phenylalanine

et al. 2022

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Dipeptides have emerged as attractive building blocks for supramolecular materials thanks to their low-cost, inherent biocompatibility, ease of preparation, and environmental friendliness as they do not persist in the environment. In particular, hydrophobic amino acids are ideal candidates for self-assembly in polar and green solvents, as a certain level of hydrophobicity is required to favor their aggregation and reduce the peptide solubility. In this work, we analyzed the ability to self-assemble and the gel of dipeptides based on the amino acids norvaline (Nva) and phenylalanine (Phe), studying all their combinations and not yielding to enantiomers, which display the same physicochemical properties, and hence the same self-assembly behavior in achiral environments as those studied herein. A single-crystal X-ray diffraction of all the compounds revealed fine details over their molecular packing and non-covalent interactions.

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Section: Discussionmentioning

confidence: 99%

Self-Assembly and Gelation Study of Dipeptide Isomers with Norvaline and Phenylalanine

et al. 2022

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“…Following this, the cells were counterstained with hematoxylin, immersed in 1% ammonia, and stained with eosin, before being rewashed with PBS. Images were then obtained using a light microscope (Optika IM3, Italy) (Javrushyan et al, 2022). 2 7.The preparation of the samples for determination of arginase activity, and changes in NO and MDA quantity Arginase and NO activity, as well as changes in MDA quantity, were analyzed in HeLa and A549 cells treated with AgNPs.…”

Section: Mtt Cytotoxicity Assaymentioning

confidence: 99%

Royal Jelly-Mediated Silver Nanoparticles Show Promising Anti-Cancer Effect on HeLa and A549 Cells Through Modulation of the VEGFa/PI3K/Akt/MMP-2 Pathway

Kocharyan,

Marutyan,

Nadiryan

et al. 2024

Preprint

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Cancer poses a significant challenge in the medical field, requiring thorough investigation into its mechanisms and the development of effective treatments. Recently, there has been increasing interest in integrating drugs with metal nanoparticles, which are notable for their unique size and physicochemical properties, aiming to enhance anticancer efficacy. Silver nanoparticles (AgNPs), especially those obtained through environmentally friendly methods known as green synthesis, have garnered attention. Royal jelly (RJ), a substance produced by bees recognized for its antioxidant, anti-inflammatory, and antibacterial properties, is particularly interesting. This study focuses on the green synthesis of AgNPs using royal jelly and its bioactivity against cancer cells. It provides a detailed characterization of the nanoparticles and examines their effects on cancer cells, specifically Hela cervical cancer and A549 lung cancer cell lines. The results highlight the cytotoxicity induced by AgNPs in HeLa and A549 cells, which is mediated through apoptosis via the PI3K/AKT signaling pathway. Our research findings demonstrate that one of the mechanisms underlying cell death involves increased concentration of ROS/RNS and downregulation of the VEGFa/MMP-2/COX-2 pathway. This study is among the few to elucidate the mechanism of the anticancer effects of nanoparticles synthesized through this method. Overall, our research contributes to the ongoing exploration of cancer biology and offers insights into potential therapeutic approaches by harnessing the capabilities of green-synthesized nanoparticles.

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“…Increase in the local levels of nitric oxide in humans and responsiveness to L-arginine as a nitric oxide precursor [33] Patients with fibrosis and severe secondary Raynaud's phenomenon phenotypes at L-arginine-based therapies 1-2 g/day-10 g/day NO metabolism in fibrosis and severe secondary Raynaud's phenomenon phenotypes eNOS, iNOS [34] Patients with primary or secondary Raynaud's phenomenon at L-arginine-based therapy Endothelial-derived mediators Increased nitric oxide synthesis [35] Review of data from animal and clinical studies Analysis of the states of hypertension, diabetes, hypercholesterolaemia, and vascular inflammation L-arginine improved treatment of cardiovascular disorders via the NO pathway [36] Rats with high-fat diet and streptozotocin-induced hyperglycaemia, arginase inhibition (via L-norvaline) and supplementation (via L-arginine) L-arginine acted as a potent antihyperglycaemic agent Inhibition of arginase provided an antihyperglycaemic effect, NO protected against oxidative stress and hypercholesterolaemia [37] Patients with acute coronary syndrome, myocardial infarction and metabolic syndrome, L-arginine (4.2 g)/L-carnitine (2.0 g) in infusions for 28 days…”

Section: Improved Endothelial Dysfunction By L-arginine Supplementationmentioning

confidence: 99%

The Effectiveness of L-arginine in Clinical Conditions Associated with Hypoxia

Kurhaluk

2023

IJMS

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The review summarises the data of the last 50 years on the effectiveness of the amino acid L-arginine in therapeutic practice in conditions accompanied by different-origin hypoxia. The aim of this review was to analyse the literature and our research data on the role of nitric oxide in the modulation of individual physiological reactivity to hypoxia. The review considers the possibility of eliminating methodological conflicts in the case of L-arginine, which can be solved by taking into account individual physiological reactivity (or the hypoxia resistance factor). Considerable attention is paid to genetic and epigenetic mechanisms of adaptation to hypoxia and conditions of adaptation in different models. The article presents data on the clinical effectiveness of L-arginine in cardiovascular system diseases (hypertension, atherosclerosis, coronary heart disease, etc.) and stress disorders associated with these diseases. The review presents a generalised analysis of techniques, data on L-arginine use by athletes, and the ambiguous role of NO in the physiology and pathology of hypoxic states shown via nitric oxide synthesis. Data on the protective effects of adaptation in the formation of individual high reactivity in sportsmen are demonstrated. The review demonstrates a favourable effect of supplementation with L-arginine and its application depending on mitochondrial oxidative phosphorylation processes and biochemical indices in groups of individuals with low and high capacity of adaptation to hypoxia. In individuals with high initial anti-hypoxic reserves, these favourable effects are achieved by the blockade of NO-dependent biosynthesis pathways. Therefore, the methodological tasks of physiological experiments and the therapeutic consequences of treatment should include a component depending on the basic level of physiological reactivity.

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Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats

Cited by 13 publications

References 64 publications

Self-Assembly and Gelation Study of Dipeptide Isomers with Norvaline and Phenylalanine

Self-Assembly and Gelation Study of Dipeptide Isomers with Norvaline and Phenylalanine

Royal Jelly-Mediated Silver Nanoparticles Show Promising Anti-Cancer Effect on HeLa and A549 Cells Through Modulation of the VEGFa/PI3K/Akt/MMP-2 Pathway

The Effectiveness of L-arginine in Clinical Conditions Associated with Hypoxia

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