Antihyperglycemic Activity of Phenolics from <i>Pterocarpus marsupium</i>

Manickam, M.; Ramanathan, Meena; Ma, Jahromi; Jp, Chansouria; Ab, Ray

doi:10.1021/np9607013

Cited by 223 publications

(157 citation statements)

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“…We have been investigating the effects of phytochemicals on the prevention of cancer, using in vitro and ex vivo assay systems and have already reported that some food components, such as carotenoids, tea catechins, and resveratrol, have anti-proliferative and/or anti-invasive properties on hepatoma cells (Kozuki et al 2000;Zhang et al 2000a;Kozuki et al 2001). Pterostilbene (trans-3,5-dimethoxy-4 0 -hydroxystilbene) is a naturally occurring stilbenoid compound isolated from several natural plant sources including several types of grapes (Adrian et al 2000), blueberries (Rimando et al 2002), and the stem bark of several trees used in folk medicine such as Pterocarpus marsupium (Manickam et al 1997) and Guibourtia tessmanii (Fuendjiep et al 2002). Pterostilbene is an analogue of a well-studied stilbene, resveratrol.…”

Section: Introductionmentioning

confidence: 99%

Anti-proliferative effect of pterostilbene on rat hepatoma cells in culture

2014

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Pterostilbene, a methoxylated analogue of resveratrol, is a natural compound primarily found in blueberries and several types of grapes. However, little is known about the effect of pterostilbene on the proliferation of hepatoma cells and its modes of actions. This study was undertaken to characterize its ability to suppress the proliferation of hepatoma AH109A cells and the possible mechanism(s) involved. Pterostilbene showed a significant and dose-dependent effect on the anti-proliferative activity against AH109A cells. Pterostilbene exerted little or no effect on the proliferation of rat L6 myoblasts and rat skin fibroblasts. Pterostilbeneloaded rat sera could significantly inhibit the proliferation of AH109A cells, which suggests that pterostilbene could be absorbed through gastrointestinal tract and retain its anti-proliferative activity. Pterostilbene arrested the cell cycle of AH109A cells at G0/ G1 phase and reduced the protein expression of cyclindependent kinase 4 and cyclin-dependent kinase 6 dose-dependently. We also found that pterostilbene could significantly increase the intracellular peroxide level of AH109A cells, which may be involved in its anti-proliferative activity.

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Section: Introductionmentioning

confidence: 99%

Anti-proliferative effect of pterostilbene on rat hepatoma cells in culture

2014

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“…Pterostilbene (3,5-dimethoxy-4#-hydroxy-trans-stilbene) was first isolated from red sandalwood (Pterocarpus santalinus; Seshadri, 1972) and is one of the active constituents of Pterocarpus marsupium, which is used in traditional medicine for the treatment of diabetes. Indeed, pterostilbene was found to decrease significantly plasma Glc levels in hyperglycemic rats (Manickam et al, 1997). Pterostilbene has also been reported to have hypolipidemic properties comparable to clinically used fibrate lipid-lowering drugs (Rimando et al, 2005).…”

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confidence: 98%

A Stress-Inducible Resveratrol O-Methyltransferase Involved in the Biosynthesis of Pterostilbene in Grapevine

et al. 2008

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Stilbenes are considered the most important phytoalexin group in grapevine (Vitis vinifera) and they are known to contribute to the protection against various pathogens. The main stilbenes in grapevine are resveratrol and its derivatives and, among these, pterostilbene has recently attracted much attention due both to its antifungal and pharmacological properties. Indeed, pterostilbene is 5 to 10 times more fungitoxic than resveratrol in vitro and recent studies have shown that pterostilbene exhibits anticancer, hypolipidemic, and antidiabetic properties. A candidate gene approach was used to identify a grapevine resveratrol O-methyltransferase (ROMT) cDNA and the activity of the corresponding protein was characterized after expression in Escherichia coli. Transient coexpression of ROMT and grapevine stilbene synthase in tobacco (Nicotiana benthamiana) using the agroinfiltration technique resulted in the accumulation of pterostilbene in tobacco tissues. Taken together, these results showed that ROMT was able to catalyze the biosynthesis of pterostilbene from resveratrol both in vitro and in planta. ROMT gene expression in grapevine leaves was induced by different stresses, including downy mildew (Plasmopara viticola) infection, ultraviolet light, and AlCl 3 treatment.

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“…[12][13][14] When anti-diabetic effects of Vijaysar was compared with Glimepiride in present study, only 2h PG glucose was comparable to Glimepiride, while previous studies mentioned that all parameters of Vijaysar group was comparable to Tolbutamide, Glibenclamide, and Metformin. 5,[15][16][17] Vijaysar also decreases the plasma level of HbA1c which suggest long term effects (3 months) on blood glucose. Various studies had shown that Vijaysar exerts multiple effects on glucose metabolism and lipid metabolism which are responsible for its anti-diabetic effects and prevent deleterious effect of diabetes on various organs.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of vijaysar, aloevera alone and their combination in the treatment of newly diagnosed cases of type 2 diabetes mellitus: a randomized single blind prospective study

Maurya

Jain

Pathak

et al. 2017

Int J Basic Clin Pharmacol

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Background: Diabetes mellitus is a disease was known since ancient time and all system of medicine over world were tried to cure this disease. Unfortunately the numbers of diabetes patients are increasing day by day due to many risk factors such as sedentary life, obesity etc.Methods: A total of 120 patients with newly diagnosed type 2 diabetes mellitus attending OPD of UPUMS, Saifai, Etawah, Uttar Pradesh, India, were included in the study. Patients were divided into 4 groups. Group-1, 2, 3 and 4 received Aloevera, Vijaysar, Aloevera + Vijaysar and Glimepiride respectively for thirteen weeks. Sample for fasting blood sugar and postprandial blood sugar were measured at baseline, 1st, 2nd, 3rd, 5th, 8th and at 13th week. HbA1c and Lipid profile were measured at baseline and at thirteen week.Results: Significant decrease in FPG, 2hPG, and HbA1c level were achieved in all groups but effects was maximum in Glimepiride group. Vijaysar had shown better glucose control than Aloevera as well as Aloevera + Vijaysar group. Synergism was shown by both herbal drugs for FPG control but not for 2hPG. The Effect of Vijaysar alone on 2hPG was similar to Glimepiride.Conclusions: Vijaysar could be a promising herbal drug for the treatment of mild uncomplicated cases of type-2 diabetes mellitus; however both drugs have shown synergism for FPG control. Both herbal drugs were safe during our study, only one patient of Vijaysar group had complaint of diarrhoea, which was subsided one week later.

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Antihyperglycemic Activity of Phenolics from Pterocarpus marsupium

Cited by 223 publications

References 16 publications

Anti-proliferative effect of pterostilbene on rat hepatoma cells in culture

Anti-proliferative effect of pterostilbene on rat hepatoma cells in culture

A Stress-Inducible Resveratrol O-Methyltransferase Involved in the Biosynthesis of Pterostilbene in Grapevine

Efficacy of vijaysar, aloevera alone and their combination in the treatment of newly diagnosed cases of type 2 diabetes mellitus: a randomized single blind prospective study

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