Antihyperglycemic and antidyslipidemic agent from Aegle marmelos

Narender, Tadigoppula; Shweta, Singh; Tiwari, Piyush; Reddy, K. Papi; Khaliq, Tanvir; Prathipati, Philip; Puri, Anju; Srivastava, Arvind K.; Chander, Ramesh; Agarwal, Shikha; Raj, Kanwal

doi:10.1016/j.bmcl.2006.12.037

Cited by 105 publications

(42 citation statements)

References 39 publications

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“…Petroleum ether extract contains fats and fixed oil while aqueous extract contains amino acids, tannins (condensed and pseudo tannins) and starch [5]. IR has been reported to possess various pharmacological actions, mainly antidiabetic [6], antiinflammatory [7], nephroprotective [8], antibacterial [9], antioxidant and antimicrobial activity [10]. Further, the principle constituents of IR such as sinapic and ferulic acids have exhibited behavioural and pharmacological…”

Section: Introductionmentioning

confidence: 99%

Effect of Extraction Solvent on the Phytoconstituents of Aegle marmelos (L.) Correa

Sulaiman¹,

Shahida²,

Balachandran³

2015

JNR

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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Section: Introductionmentioning

confidence: 99%

Effect of Extraction Solvent on the Phytoconstituents of Aegle marmelos (L.) Correa

Sulaiman¹,

Shahida²,

Balachandran³

2015

JNR

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“…38 These results demonstrate that the recipe could be improve renal and liver damage 39,40 The renal dysfunction improvement could be justified by total protein increasing, as in diabetic individuals nephropathy is the main factor for protein excretion in urine. [41][42][43][44] Diabetes has been a great influence on lipid metabolism caused by streptozotocin-induced as a result to increasing of TC and TG levels which observed by impaired with liver function from diabetic rat damage. [44][45] Our data showed improvement of lipid profiles which increased HDL, decreased TC, TG and LDL in the diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

“…[41][42][43][44] Diabetes has been a great influence on lipid metabolism caused by streptozotocin-induced as a result to increasing of TC and TG levels which observed by impaired with liver function from diabetic rat damage. [44][45] Our data showed improvement of lipid profiles which increased HDL, decreased TC, TG and LDL in the diabetic rats. 15,16,41 The plants could be prevent and treat disorders of diabetes which mainly responsible for mediating the formation by peroxi-dation of unsaturated fatty acids, cholesterol and lipoproteins, increased lipid peroxidation leads to membrane damage and consequently organs dysfunction being this an important risk factor for atherosclerosis and coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

“…15,16,41 The plants could be prevent and treat disorders of diabetes which mainly responsible for mediating the formation by peroxi-dation of unsaturated fatty acids, cholesterol and lipoproteins, increased lipid peroxidation leads to membrane damage and consequently organs dysfunction being this an important risk factor for atherosclerosis and coronary artery disease. 44,46,[48][49] Decreasing on lipid levels and consequently the reduction of lipid peroxidation were improved due to the high antioxidant potential of polyphenolic compounds that act by mechanisms of reaction inhibition in the peroxidation chain and could be reduce complication resulting from diabetes. [48][49] …”

Section: Discussionmentioning

confidence: 99%

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Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Konsue¹,

Talubmook²

2018

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Context:Abutilon indicum and Mimosa pudica were a folklore recipe in Northeastern of Thailand. The recipe was reported that claim to diabetic treatment. Aims: The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The recipe were composed of whole plants from A. indicum and M. Pudica (1:1 w/w) powder. The pound plants were macerated with aqueous (AMA), hydro-ethanol (AMHE) and 80% ethanol (AME) to crude extracts. The AMA, AMHE and AME at the doses of 125, 250 and 500 mg/kg body weight (b.w.) were administered orally daily in diabetic rats during eight weeks. Fasting blood glucose levels (FBG) were measured at weekly. The serum insulin levels and blood biochemical data including blood urea nitrogen (BUN), creatinine (CREA), total protein (TP), albumin (Alb), serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were estimated at the end of experiment. Results: All doses of the extracts were showed significantly (p<0.05) decreasing percent age of FBG in diabetic rats. Especially, AME 125 mg/ kg b.w. was showed more potent significantly (p<0.05) decreasing percentage of FBG at week of 2, 5, 7 and 8. The serum insulin levels of all doses administered with the extracts were significantly (p< 0.05) higher than diabetic control group. On the other hand, all doses of the extracts were significantly (p< 0.05) decreasing ALT and ALP lower than diabetic control group. While, AMA and AMHE at the doses of 250 and 500 mg/kg b.w. were increased HDL, but decreased TC, TG and LDL. Conclusion: The study was proved to diabetic treatment and improvement of diabetic stage and blood biochemical parameters. In addition, the experiment was confirmed to folklore traditional use.

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“…Arecoline, an alkaloid isolated from Areca catechu was reported to have hypoglycemic activity in animal model [96]. Aegeline, an alkaloidal amide from the leaves of Aegle marmelos was found to possess antihyperglycemic activity with suggested β 3 -adrenergic receptor activity [97]. Trigonelline isolated from a known hypoglycemic plant Trigonella foeum graceum could lower blood glucose level in alloxan treated diabetic rats through regeneration of new islets [98].…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic Studies on the Leaf Extract and Active Fractions of Newbouldia laevis (Bignoniaceae)

Osigwe¹,

Akah²,

Nworu³

et al. 2015

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Optimal control of chronic hyperglycemia prevents both micro and macro vascular complications-a leading cause of morbidity and mortality in diabetic subjects. This study was undertaken to give credence to the traditional use of Newbouldia laevis leaves in the treatment of diabetes mellitus (DM). Dichloromethane-methanol (1:1) extract (DME) of N. laevis leaves was prepared by cold maceration. Separation of DME into column chromatographic fractions yielded the n-hexane fraction (HF), ethylacetate fraction (EF) and methanol fraction (MF). The extract and fractions were evaluated for antihyperglycemic activity in alloxanized diabetic rats. The results showed that the oral administration of extract and fractions (250, 500, 1000 mg/kg) caused a significant (P < 0.5) and dose-dependent reduction in blood glucose level in diabetic rats. The hypoglycemic potency after 24 h was in the order MF (methanol fraction; 56.31%) > DME (dichloromethane/methanol extract; 36.19%) > EF (ethylacetate fraction; 20.70%) > HF (n-hexane fraction; 10.09. The methanol fraction, which showed the highest potency in oral glucose tolerance test (OGTT), was further separated into column chromatographic sub-fractions-F₁, F₂, F₃ and F₄ fractions. These sub-fractions were evaluated for antihyperglycemic activity. Sub-fractions F₁, F₂ and F₃ (1000 mg/kg) did produce significant (P > 0.05) reduction in blood glucose level after 24 h. Sub-fraction F4 (50, 100, 200 mg/kg), however caused a significant (P < 0.05) and dose-dependent reduction in blood glucose level. The reduction at 200 mg/kg dose of F 4 (74.57%) was significantly (P < 0.05) higher than that of glibenclamide (58.04%). These findings suggest that leaf extract and fractions of Newbouldia laevis possess antihyperglycemic activities and can be the basis for the folk use N. laevis in management of diabetes mellitus.

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Antihyperglycemic and antidyslipidemic agent from Aegle marmelos

Cited by 105 publications

References 39 publications

Effect of Extraction Solvent on the Phytoconstituents of <i>Aegle marmelos</i> (L.) Correa

Effect of Extraction Solvent on the Phytoconstituents of <i>Aegle marmelos</i> (L.) Correa

Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Antihyperglycemic Studies on the Leaf Extract and Active Fractions of <i>Newbouldia laevis</i> (Bignoniaceae)

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Antihyperglycemic and antidyslipidemic agent from Aegle marmelos

Cited by 105 publications

References 39 publications

Effect of Extraction Solvent on the Phytoconstituents of <i>Aegle marmelos</i> (L.) Correa

Effect of Extraction Solvent on the Phytoconstituents of <i>Aegle marmelos</i> (L.) Correa

Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Antihyperglycemic Studies on the Leaf Extract and Active Fractions of &lt;i&gt;Newbouldia laevis&lt;/i&gt; (Bignoniaceae)

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Antihyperglycemic Studies on the Leaf Extract and Active Fractions of <i>Newbouldia laevis</i> (Bignoniaceae)