Antihyperglycemic and antihyperlipidemic activities of hydroethanolic extract of the fruit of Baillonella toxisperma in streptozotocin-induced diabetic rats

Nguemto, Guy Roussel Takuissu; Fonkoua, Martin; Aimé, Youovop Fotso Janvier; Lanvin, Edoun Ebouel Ferdinand; Edwige, Dibacto Kemadjou Ruth; Boris, Azantsa Kingue; Laure, Ngondi Judith; Enyong, Oben Julius

doi:10.1016/j.metop.2022.100199

Cited by 4 publications

(6 citation statements)

References 40 publications

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“…The present study reveals that the administration of HgCl 2 increases kidney weight, which is consistent with previous studies indicating that HgCl 2 increases kidney weight in rats . Furthermore, the results corroborate the findings of a study that investigated the effect of ECP leaf extract against lead exposure in albino rat, where kidney weight decreased and body weight increased, reducing the accumulation of heavy metals in the rats. , Simultaneous pretreatment with NAC and different doses of ECP decreased kidney weight.…”

Section: Resultssupporting

confidence: 92%

“…These results demonstrated a significant decrease in body weight and an increase in kidney weight in the heavy-metal-induced toxicity animals, which are consistent with previous studies. 55,56 Like body weight, kidney weight was also affected in the HgCl 2induced nephrotoxic rats. The present study reveals that the administration of HgCl 2 increases kidney weight, which is consistent with previous studies indicating that HgCl 2 increases kidney weight in rats.…”

Section: Resultsmentioning

confidence: 99%

“…group showed a remarkable upregulation of GST and downregulation of OH – compared to the HgCl 2 group. The development of oxidative stress in humans or animals can affect the important body tissues including the liver and kidney, among other vital organs . In extreme cases, if not treated with therapeutic or chelating agents, it may lead to CKD.…”

Section: Resultsmentioning

confidence: 99%

“…57 Furthermore, the results corroborate the findings of a study that investigated the effect of ECP leaf extract against lead exposure in albino rat, where kidney weight decreased and body weight increased, reducing the accumulation of heavy metals in the rats. 55,58 Simultaneous pretreatment with NAC and different doses of ECP decreased kidney weight. 3.3.…”

Section: Resultsmentioning

confidence: 99%

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Mercuric Chloride Induced Nephrotoxicity: Ameliorative Effect of Carica papaya Leaves Confirmed by Histopathology, Immunohistochemistry, and Gene Expression Studies

Maria Francis,

Karunakaran,

Ashfaq

et al. 2023

ACS Omega

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The present study analyzes the efficacy of the ethanolic extract of C. papaya leaves (ECP) against HgCl 2 -induced nephrotoxicity. The effects on the biochemical and percentage of body and organ weight against HgCl 2 -induced nephrotoxicity in female Wistar rats were studied. Wistar rats were divided into five groups with six animals in each group: control, HgCl 2 (2.5 mg/kg b.w.), N-acetylcysteine (NAC 180 mg/kg) + HgCl 2 , ECP (300 mg/kg b.w.) + HgCl 2 , and ECP (600 mg/kg) + HgCl 2 groups. After 28 days of study, animals were sacrificed on the 29th day to harvest the blood and kidneys for further analysis. The effect ECP was analyzed by immunohistochemistry (NGAL) and real-time PCR (KIM-1 and NGAL mRNA) in HgCl 2 -induced nephrotoxicity. The results revealed that the HgCl 2 group showed prominent damage in the proximal tubules and glomerulus of nephrons and enormous expression of NGAL in immunohistochemistry and KIM-1 and NGAL in real-time PCR compared to the control group. The simultaneous pretreatment with NAC (180 mg/kg) and ECP (600 and 300 mg/kg) reduced renal damage and expression of NGAL in immunohistochemistry and KIM-1 and NGAL gene in real-time PCR. This study attests to the nephroprotective effect of ECP against HgCl 2 -induced toxicity.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Mercuric Chloride Induced Nephrotoxicity: Ameliorative Effect of Carica papaya Leaves Confirmed by Histopathology, Immunohistochemistry, and Gene Expression Studies

Maria Francis,

Karunakaran,

Ashfaq

et al. 2023

ACS Omega

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“…B. toxisperma also improves sexual performance and reproductive dysfunction induced by stress [ 3 ]. Although several biological studies have been conducted on the bark, fruit and leaves of B. toxisperma [ 11 , 12 ], very little work has been published on the compounds responsible for the biological activities of the plant. One of the few studies that isolated a compound (3-hydroxy uridine, a plant growth inhibitor) was performed by Hajime et al [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and Identification of Antibacterial Compounds from Baillonella toxisperma Bark Using a LC-MS/MS and Molecular Networking Approach

et al. 2023

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Baillonella toxisperma is a medicinal plant used in northern Gabon to treat microbial diseases. It is a plant well-known by local populations, but very few studies have focused on the molecules responsible for the antibacterial activities of B. toxisperma. This study proposes a dereplication strategy based on molecular networking generated from HPLC-ESI-Q/TOF data, allowing investigation of the molecules responsible for the antibacterial activity of B. toxisperma. From this strategy, eighteen compounds were putatively identified. All of these compounds belonged mainly to five families of natural compounds, including phenylpropanolamines, stilbenes, flavonoids, lignans and phenolic glycosides. The chemical study carried out from the bark of B. toxisperma allowed us to identify, for the first time, compounds such as resveratrol and derivatives, epicatechin, epigallocatechin and epigallocatechin gallate. In addition, antibacterial activity (diffusion method and microdilution) and cytotoxicity (Cell Counting Kit-8 (CCK-8 Assay)) in vitro were evaluated. The crude ethanolic extract, as well as the fractions of B. toxisperma, showed significant antibacterial activity. However, the ethanolic fractions F2 and F4 presented high antibacterial activity compared to the crude extract. Cytotoxicity studies on colon-cancer cells (Caco-2) and human keratinocyte cells (HaCaT) showed moderate cytotoxicity in both cell types. This study clearly shows the therapeutic potential of the ethanolic extract of the bark of B. toxisperma and provides information on the phytochemical composition and bioactive compounds of the plant.

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Extraction of Phytoconstituents for Lifestyle Diseases

Tchamgoue,

Ngandjui,

Talla

et al. 2023

Role of Herbal Medicines

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Antihyperglycemic and antihyperlipidemic activities of hydroethanolic extract of the fruit of Baillonella toxisperma in streptozotocin-induced diabetic rats

Cited by 4 publications

References 40 publications

Mercuric Chloride Induced Nephrotoxicity: Ameliorative Effect of Carica papaya Leaves Confirmed by Histopathology, Immunohistochemistry, and Gene Expression Studies

Mercuric Chloride Induced Nephrotoxicity: Ameliorative Effect of Carica papaya Leaves Confirmed by Histopathology, Immunohistochemistry, and Gene Expression Studies

Cytotoxicity and Identification of Antibacterial Compounds from Baillonella toxisperma Bark Using a LC-MS/MS and Molecular Networking Approach

Extraction of Phytoconstituents for Lifestyle Diseases

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