Antihyperglycemic and Antioxidant Activities of Medicinal PlantStereospermum suaveolensin Streptozotocin-induced Diabetic Rats

Abstract

The ethanol extract of Stereospermum suaveolens (EESS) bark was evaluated for its antihyperglycemic in addition to antioxidant effects in streptozotocin (STZ)-induced diabetic rats by acute and subacute models at dose levels of 200 and 400 mg/kg body weight, given orally. The ethanol extract showed a significant reduction in fasting blood glucose levels when compared to the standard drug, oral Glibenclamide (0.5 mg/kg body weight). The serum of rats treated with ethanol extract showed decreased levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase, bilirubin, creatinine, urea, total cholesterol, triglycerides, and increased level of total proteins. EESS showed reduction in thiobarbituric acid reactive substances level and significantly increased the body weight (P < .001), glycogen, reduced glutathione, superoxide dismutase, and catalase activities, compared with STZ diabetic control in a dose-dependent manner. This finding shows that the ethanol extract of Stereospermum suaveolens exhibits potent antihyperglycemic and antioxidant properties.

Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin–induced diabetic Wistar rats

“…This observation agrees with report of Baskar et al [17] who reported antihyperglycemic activity of aqueous root extract of Rubia cordifolia in streptozotocin-induced diabetic rats. The alterations of these parameters are well known to cause anaemic condition in man [18] . Following plant extract administration, the level of RBC and its related indices were appreciably improved especially at 200 mg/kg.…”

Haematology and serum biochemistry of alloxan-induced diabetic rats administered with extracts of Phragmanthera incana (Schum.) Balle

“…The alterations in these haematological parameters have also been reported in humans (Balasubraimanian et al, 2009). Clinically, MCV and MCHC levels are lowered in cases of iron deficiency, sideroblastic anaemia, thalassemia and lead poisoning while they are elevated in liver diseases, megaloblastic anaemia, folic acid and vitamin B 12 deficiency (Janz et al, 2013).…”

Protective Effect of Ethyl Acetate Fraction of Stereospermum Suaveolens Against Hepatic Oxidative Stress in STZ Diabetic Rats

“…This finding suggests that the ethyl acetate fraction of EESS had a potent antihyperglycemic activity in diabetic rats, which corresponded to the previous finding that the crude ethanol extract reduced blood glucose level in STZ diabetic rats. [14]…”

“…Previous studies in our laboratory showed that crude ethanol extract and ethyl acetate fraction of S. suaveolens have antihyperglycemic effects in streptozotocin (STZ)-induced diabetic rats. [1415] No reports are available on the antioxidant activity of ethyl acetate fraction in the liver. Thus, the objective of the present study was to further explore our previous data by focusing now on the protective effect of S. suaveolens ethyl acetate fraction against oxidative stress in the liver of STZ-induced diabetic rats.…”