Antihyperglycemic and antioxidant activity of Viscum album extract

Abstract

The antihyperglycemic and antioxidant effects of water extract of local Viscum album in alloxanizedrats were investigated. This study performed during 2009 in Babol University of medical sciences (Mazandaran Province, Iran). V. album leaves growing on oaks collected and extracted with hot water. The 90 animals that were used in this investigation were male Wistar rats. 60 rats were gavaged with 500 and 1000 mg/kg/day of V. album extract. One hour after final feeding, freshly prepared alloxan injected subcutaneously. Then blood glucose level was measured according to glucose oxidase method. The antioxidant activity of serum was determined by FRAP assay and serum insulin level was measured with ELISA. The administration of V. album extract (500 and 1000 mg/kg/day) significantly reduced the increase in serum glucose concentration in alloxan-hyperglycemic rats. Both the extracts from V. album enhance the serum insulin level as compared to control rats. Serum antioxidant activity in low dose of extract was significantly higher at 48 and 72 h after alloxan injection. Serum antioxidant activity in the high dose was significantly higher at 24, 48 and 72 h. This study demonstrated that V. album extract reduced the blood glucose and increases the antioxidant power of alloxanized-rats. Much more work is clearly needed before phytotherapy for diabetes can be advanced to the clinic.

Phytochemical profile and therapeutic potential ofViscum albumL.

“…It has also been demonstrated that active constituents are heat resistant (Gray & Flatt 1999). A significant decrease in serum glucose level accompanied by an increase of the serum insulin level was observed in alloxan-hyperglycaemic rabbits and rats after administration of mistletoe water extract (Ohiri et al 2003;Shahaboddin et al 2011). The extract enhanced the serum's antioxidant activity which is very important in the prevention of diabetic complications (Shahaboddin et al 2011).…”

Comparative Proximate Composition and Hypoglycemic Properties of Three Medicinal Plants (Verononia amygdalina, Azadirachta indica and Moringa oleifera).

“…Likewise, rats fed by gavage with 500 and 1000 mg/kg/day of Viscum album extract for 72 h caused significant (p < 0.05) reduction in blood glucose and increased antioxidant power of alloxanized rats. [68] These findings indicate that the route and mode of drug administration alters the level of drug delivery and efficacy.…”

Activities of Three Erythrocyte Enzymes of Hyperglycemic Rats (Rattus norvegicus) Treated with Allium sativa Extract.

“…[38][39][40][41] The Figure 1. Erythrocyte glutathione S-transferases activity of hyperglycemic rats with/without glycemic control.…”