Antihyperglycemic and Antioxidative Effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in Mice Fed with a High Fat Diet

Abstract

The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative status in mice under high fat diet conditions was investigated. The mice were randomly divided and given experimental diets for six weeks: normal control (NC group), high fat (HF group), and high fat supplemented with either HEMC (HF+HEMC group) or HPMC (HF+HPMC group). At the end of the experimental period, the HF group exhibited markedly higher blood glucose and insulin levels as well as a higher erythrocyte lipid peroxidation rate relative to the control group. However, diet supplementation of HEMC and HPMC was found to counteract the high fat-induced hyperglycemia and oxidative stress via regulation of antioxidant and hepatic glucose-regulating enzyme activities. These findings illustrate that HEMC and HPMC were similarly effective in improving the glucose metabolism and antioxidant defense system in high fat-fed mice and they may be beneficial as functional biomaterials in the development of therapeutic agents against high fat dietinduced hyperglycemia and oxidative stress.

ω‐Imidazolyl‐alkyl derivatives as new preclinical drug candidates for treating non‐alcoholic steatohepatitis

“…HPMC or guar gum had previously caused reduced weight gain in rats administered an HFD (Brockman, 2014). Comparable results have been reported for mice and hamsters as well (Ban et al, 2012; Kim et al, 2015).…”

Impact of Dietary Fibers on Nutrient Management and Detoxification Organs: Gut, Liver, and Kidneys

“…The "second hit" is thought to come from a variety of sources, including bacterial overgrowth (103). In addition to affecting the gut barrier, DFs have also been shown to decrease erythrocyte lipid peroxidation and increase antioxidant enzyme activity (i.e., hepatic and erythrocyte superoxide dismutase and catalase) (104) and alter detoxifying enzymes in the liver (i.e., increase protein expression of cytochrome p450 1A2) (105,106). Reduced concentrations of cytochrome p450 1A2 have been observed in human and NAFLD animal models (106).…”

“…Fiber-induced gut changes can result in enhanced gut barrier function that protects the liver and kidney from translocation of proinflammatory bacteria and bacterial products. This could allow the liver and kidneys to devote more capacity to metabolism-associated processes rather than controlling inflammation (104). In addition, DF increases microbial sequestration of nitrogen in the gut, resulting in increased fecal nitrogen excretion and reduced concentrations of nitrogenous metabolites in the blood.…”

Silver nanoparticles fabricated by reducing property of cellulose derivatives

“…From the best of our knowledge, there is very less report on antioxidant or reducing property of cellulose derivatives. Previously, HPMC was reported to have antioxidant activity but the mechanism of action was lipid peroxidation (28), which might not be related directly to the reducing property. Zimoch-Korzycka et al reported free radical scavenging property of HPMC using 2,2-diphenyl-1-picrylhydrazyl as free radicals (DPPH) and reducing property using FRAP assay (29).…”