Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats

Abstract

Plants with antidiabetic activities provide important sources for the development of new drugs in the treatment of diabetes mellitus. In the present study, we investigated possible antihyperglycemic and antioxidative activities of the aerial part of the Matricaria chamomilla L. ethanolic extract (MCE) in streptozotocin (STZ; 70 mg/kg, i.p.)-induced diabetic rats. The following groups were assigned; sham (did not receive any substance), STZ + distilled water (control), STZ + 5 mg/kg glibenclamide, STZ + 20 mg/kg MCE, STZ + 50 mg/kg MCE, STZ + 100 mg/kg MCE. Diabetic rats were treated for 14 days by gavage. Postprandial blood glucose levels, malondialdehyde, reduced glutathione (GSH), nitrate, nitrite, ascorbic acid, retinol, beta-carotene, superoxide dismutase, and catalase levels were measured, and immunohistochemical studies were performed in all of the groups. The obtained data showed that STZ resulted in oxidative stress and affected the antioxidant status. Treatment with different doses of MCE significantly reduced postprandial hyperglycemia and oxidative stress, and augmented the antioxidant system. In histological investigations, MCE treatment protected the majority of the pancreatic islet cells, with respect to the control group. As a result, MCE exhibited significant antihyperglycemic effect and protected beta-cells in STZ-diabetic rats, in a dose-dependent manner, and diminished the hyperglycemia-related oxidative stress.

Identification of the Therapeutic Effects of Gamma-Irradiated Chamomile Aqueous Extract Against Alcohol Induced Hepato-nephrotoxicity in Rats

“…The study of Chandrasekhar et al, (2010) showed that chamomile methanolic extracts revealed a dose dependent nephroprotective activity by a significant decreasein lipid peroxidation and increases in the SOD, CAT, GSH and total levels of thiol in the chamomile extract treated groups compared with the ischemia/reperfusion group. Chamomile extract contains polyphenols, chiefly catechins and their derivatives which possess antioxidant, anti-mutagenic and anti-carcinogenic effects that reduce the risk of various forms of cancer, cardiovascular and renal disorders against certain environmental agents (Cemek et al, 2008(Cemek et al, , 2010. Chamomile has been shown to lower cisplatininduced nephrotoxicity and oxidative stress (Salama et al, 2011 andSalama, 2012).…”

Bone Marrow-Derived Mesenchymal Stem cells Infusion Ameliorates Hyperglycemia, Dyslipidemia, Liver and Kidney Functions in Diabetic Rats

“…Moreover, Zafar and Naqvi [42] and Saumya and Basha [43], reported that STZ decompose inside the cell to form carbonium ions that alkylate DNA and decrease cellular nicotinamide adenine nucleotide (NAD) level which may adversely affect beta cells by interrupting respiratory enzyme activity and alteration of their mitochondrial function leading to irreversible cellular necrosis and death of beta cells resulting in permanent hyperglucemia, this changes lead to suppression and disturbance of biosynthesis and insulin secretion. Moreover, Cemek et al [44] also found that hyperglycemia is due to irreversible destruction of beta islet cells of the pancreas by STZ, causing a reduction of insulin secretion (hypoinsulinemia).…”

Screening Indian Medicinal Plants to Control Diabetes – An In silico and In vitro Approach

“…Previous studies have shown that ROS are generated in diabetic beta cells, which are combated by the over expression of antioxidants enzymes including the Super Oxide Dismutase (SOD), Catalase and Peroxidase. Antioxidants protect the beta cells from oxidative damage by scavenging the free radicals generated thus protecting from the development of diabetes [27][28][29]. Similarly the over expression of SOD in transgenic mice, has shown to inhibit the development of diabetic complications.…”