Antihyperglycemic, Antidiabetic, and Antioxidant Effects of <i>Garcinia pedunculata</i> in Rats

Ali, Md. Yousuf; Paul, Sudip; Tanvir, E. M.; Hossen, Md. Sakib; Rumpa, Nur-E Noushin; Saha, Moumoni; Bhoumik, Nikhil Chandra; Islam, Aminul; Hossain, Md. Sabir; Alam, Nadia; Gan, Siew Hua; Khalil, Ibrahim

doi:10.1155/2017/2979760

Cited by 33 publications

(28 citation statements)

References 41 publications

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“…The results are in consonance works of Reed et al [20], and Skovso et al [21] in which HFD/STZ induction produced hyperglycaemia and hyperinsulinaemia. The results are also in agreement with the works of Ali et al [22], in which treatment with glibenclamide and the methanolic extract of Garcinia pedunculata (GP) fruit, restored insulin levels in STZ-induced diabetic rats.…”

Section: Discussionsupporting

confidence: 92%

Antidiabetic and Antioxidant Effects of the Polyherbal Drug Glucoblock and Glibenclamide in Type 2 Diabetic Rats

Briggs

Nwachuku

Bartimaeus

et al. 2019

JAMPS

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The increased prevalence of diabetes, and the huge disease burden on patients has led to an increase in the use of complementary and alternative medicine in diabetes treatment and management. Aim: This study evaluates the antidiabetic and antioxidant effects of the polyherbal capsule glucoblock and glibenclamide in type 2 diabetic rats. Methodology: A total of 35 male Wistar albino rats weighing between 120-220 g were used for this study. The rats were placed on high fat diet, and diabetes induced by a single intraperitoneal injection of freshly prepared streptozotocin (STZ) (45 mg/kg body Wt). Fasting plasma glucose (FPG) was determined using the glucose oxidase method. Fasting plasma insulin (FPI), total oxidant status (TOS), total antioxidant status (TAS) and superoxide dismutase (SOD) levels were quantitatively determined by a rat-specific sandwich-enzyme linked immunosorbent assay (ELISA) method. Insulin resistance (IR) was determined using the homeostatic model assessment of insulin resistance (HOMA-IR) method. Oxidative stress index (OSI) was determined by the ratio of TOS to TAS. Phytochemical analysis was also done on the herbal capsule. Results: Mean FPG levels were significantly lower (p˂0.05) in all groups, compared to the diabetic control. Mean FPG level was significantly higher (p˂0.05) in the combination group, but showed no significant difference (p>0.05) in the glibenclamide group, and glucoblock group, compared to the negative control. HOMA-IR was significantly higher (p<0.05) in the diabetic control compared to the negative control and treatment groups. The combination group had significantly higher (p˂0.05) HOMA-IR values, whereas the individual treatment groups showed no significant difference (p>0.05) when compared to the negative control. TOS was significantly higher (p<0.05) in the diabetic control compared to the negative control and treatment groups. The treatment groups showed no significant difference (p>0.05) in TOS, compared to the negative control. There was significantly lower (p˂0.05) TAS levels in the diabetic and treatment groups, compared to the negative control. OSI values were significantly lower (p˂0.05) in all groups when compared to the diabetic control. Also, OSI values were significantly higher (p˂0.05) in the treatment groups compared to the negative control. SOD was significantly lower (p<0.05) in the diabetic control compared to the negative control and treatment groups. The treatment groups showed no significant difference (p>0.05) in SOD levels, compared to the negative control. Conclusion: Increase in total oxidant status and oxidative stress depleted antioxidant parameters. The polyherbal capsule glucoblock was effective when used alone and produced equipotent effect to the treatment with glibenclamide. However, the combination treatment did not fare better. Antioxidant therapy should be used together with antidiabetics in the management of diabetes, and care should be taken in the use herb-drug combinations.

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Section: Discussionsupporting

confidence: 92%

Antidiabetic and Antioxidant Effects of the Polyherbal Drug Glucoblock and Glibenclamide in Type 2 Diabetic Rats

Briggs

Nwachuku

Bartimaeus

et al. 2019

JAMPS

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“…The extract significantly (p < 0.05) reduced the AST, ALT and ALP levels (Table 4). This result is similar to the findings of Ali et al, (2017), in antidiabetic properties of in Rats, suggesting that Garcinia pedunculata the plant may possess hepatoprotective properties.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of the anti-diabetic potentials of Albiza zygia (DC.) stem barks in alloxan-induced diabetic rats

Okafoanyali¹,

Akah²,

Omoirri³

et al. 2020

Adv Pharm J

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Diabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both (WHO, 1999). These complications can be acute or chronic in nature. Acute complications include diabetic ketoacidosis, coma or death. Chronic complications include chronic kidney failure, heart disease, stroke, foot ulcers and damage of the eyes. In 2004, an estimated 3.4 million people died from consequences of high fasting blood sugar (WHO, 2009) and more than 80% of diabetes deaths occur in low and middle-income countries (Mathars and Loncar, 2006). Basically, the amount of glucose in the blood is regulated by insulin and glucagon. The hormone insulin is produced in the beta cells of the pancreas and helps the body cells especially liver, muscle and adipose tissue, to take up glucose in the blood for conversion/storage into other forms of energy for metabolic processes. Plants form the main ingredients of medicines in traditional systems of healing and have been the source for several major pharmaceutical drugs. More than 80% of the world's rural

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“…In Bangladesh, it is an underutilized fruit found in the north-eastern part of the country. The mature fruit is seldom used in cooking to impart sourness in curries and pulses (Islam et al, 2015), but it has many medicinal properties including antidiabetic, antiscorbutic, antidiarrhoeic, astringent, and cardiotonic (Vo et al, 2012;Sarma et al, 2016;Ali et al, 2017). To date, many studies have explored the pharmacological activity of G. pedunculata, but no attention has been paid to its allelopathic activity.…”

Section: Introductionmentioning

confidence: 99%

Study of the allelopathic activity of Garcinia pedunculata Roxb

Rob

Noguchi

2019

Plant Omics

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The allelopathic properties of plants can be used as an alternative weed control method to reduce the use of synthetic herbicides. Accordingly, the present study was carried out to determine the allelopathic activity of Garcinia pedunculata. Six different concentrations of aqueous methanol extracts of G. pedunculata fruit were prepared and used to determine their effect on the growth of eight test plants: alfalfa (Medicago sativa L.), cress (Lepidum sativum L.), lettuce (Lactuca sativa L.), rapeseed (Brassica napus L.), barnyard grass (Echinochloa crus-galli (L.) P. Beauv.), foxtail fescue (Vulpia myuros (L.) C.C. Gmel.), Italian ryegrass (Lolium multiflorum Lam.), and timothy (Phleum pratense L.). The test plants were grown in Petri dishes and after 48 h incubation, the length of the roots and shoots of the seedlings was measured and compared with control seedlings. Experiments were carried out in a completely randomized design (CRD). Analysis of variance (ANOVA) of the data was performed using the SPSS statistical package, and the I50 values were measured from a regression equation. The extracts at each concentration significantly inhibited the shoot and root growth of all the test plants, except the concentration of 0.001 g dry weight equivalent extract/mL, compared with control. At a concentration of 0.3 g of dry weight equivalent extract/mL, the shoot and root growth of all the tested plants were completely inhibited, except the shoot growth of barnyard grass. The degree of inhibition increased in line with increased extract concentration. The shoots of alfalfa and the roots of barnyard grass were determined to be the most susceptible to the G. pedunculata extract based on the concentration of extract resulting in 50% (I50) growth inhibition of the test plants. These results suggest that G. pedunculata may have allelopathic potential and may possess allelochemicals. From our study, we can conclude that G. pedunculata could be developed as an eco-friendly weed control option.

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Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats

Cited by 33 publications

References 41 publications

Antidiabetic and Antioxidant Effects of the Polyherbal Drug Glucoblock and Glibenclamide in Type 2 Diabetic Rats

Antidiabetic and Antioxidant Effects of the Polyherbal Drug Glucoblock and Glibenclamide in Type 2 Diabetic Rats

Evaluation of the anti-diabetic potentials of Albiza zygia (DC.) stem barks in alloxan-induced diabetic rats

Study of the allelopathic activity of Garcinia pedunculata Roxb

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