Antihyperglycemic, antidyslipidemic and antioxidant properties of hydromethanol extract of Eremomastax speciosa leaf in alloxan monohydrate-induced hyperglycemic rats

Onoja, Samuel O.; Effiong, UO; Chukwuocha, B.K.; Okorie-Kanu, C.C.; Ezeja, Maxwell I.; Omeh, Yusuf N.; Anaga, Aruh O.

doi:10.4314/tjpr.v19i9.17

Cited by 2 publications

(2 citation statements)

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“…Piloerection, lethargy and decreased locomotor may have been due to hypothermia, electrolytes imbalance as a result of reduced food intake and dehydration, which are characteristic derangements in Plasmodium parasitaemia. Rich anti-inflammatory and antioxidant properties of E. speciosa reported are believed to compliment the strong antiplasmodial property of H. africana in causing the regression of 34,35 these clinical signs.…”

Section: Effect Of Treatments On Clinical Signsmentioning

confidence: 88%

Therapeutic potential of concurrent administration of Hippocratea africana and Eremomastax speciosa in the treatment of Plasmodium berghei infected mice

Uwah AF,

Effiong BO,

Obot JS

et al. 2022

Ibom Med J

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Context: Despite the commonness of polyherbal therapy among the locals in the treatment of malaria in Nigeria, there are no adequate data on the therapeutic potentials and safety profile of these herbal combinations. The use of these plants in combination in the treatment of suspected and confirmed malaria infection is very common among the Niger Delta dwellers in Nigeria. Aim: To evaluate the therapeutic potential of co-administration of Hippocratea Africana, a medicinal plant with well documented antimalarial properties, and Eremomastax speciosa, a tropical plant with well reported antianaemic potential and haematoprotective properties. Materials and Methods: Thirty albino mice, whose weights ranged between 32 - 37g, were divided into five groups having six mice in each. Clinical features, weight changes and parasite clearance were evaluated to determine therapeutic potential of treatments.An inoculum which consisted of 5 x 107 Plasmodium berghei infested erythrocytes per ml of blood from a donor mouse with 64% parasitaemia was injected into each mouse by intraperitoneal route. The mice were kept at room temperature of 28.0 ± 20C for 7 days for the parasite to develop. A non-parasitized mice group served as normal control. After parasitaemia was confirmed using standard procedure, 200mg/kg and 300mg/Kg body weights of Hippocratea Africana root bark and Eremomastax speciosa leaf extracts respectively, were administered by oral routes to the respective groups of mice for 6 days. A parasitized group was treated with fixed doses of 3mg/kg body weight of Artemether and 18mg/kg body weight of Lumefantrine. Another parasitized group was left untreated. Results: Mice treated concurrently with the extracts of H. africana and E. speciosa showed a significant improvement in clinical signs in comparison to the untreated group. The mean body weights of mice administered both extracts was significantly (P < 0.05) increased when compared to the parasitized untreated mice and those treated with extracts separately. The mice treated concurrently with the two extracts also showed significant (P < 0.05) reduction in percentage parasitaemia and significant (P < 0.05) increase in percentage parasite clearance comparable to that of Artemether-lumefantrine. The parasitized untreated group recorded 50% mortality, while the group treated concurrently with the two extracts did not record any mortality. Conclusion: Concurrent administration of E. speciosa crude leaf extract and H. africana ethanolic root extract had good therapeutic potential in the treatment of Plasmodium berghei infected mice. This justified the use of these extracts by Sub-Saharan African traditional medical practitioners and Nigerian Niger Delta rural dwellers in the treatment of human malaria.

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Section: Effect Of Treatments On Clinical Signsmentioning

confidence: 88%

Therapeutic potential of concurrent administration of Hippocratea africana and Eremomastax speciosa in the treatment of Plasmodium berghei infected mice

Uwah AF,

Effiong BO,

Obot JS

et al. 2022

Ibom Med J

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“…The total flavonoid and total phenolic contents of R. vomitoria leaf extract was determined following the methods described by [29,30] .…”

Section: Determination Of Total the Flavonoid And Phenolic Contents O...mentioning

confidence: 99%

Evaluation of in vitro anthelminthic, antiproliferative and antihypertensive potentials of Rauwolfia vomitoria Afzel. (Apocynaceae) leaf extract

Ukwubile¹,

Odugu²,

Malgwi³

et al. 2019

Int. J. Adv. Biochem. Res.

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Background: Rauwolfia vomitoria Afzel. (Apocynaceae) leaf is used to treat various diseases such as ascariasis, cancer, hypertension, other cardiovascular diseases, and various diseases in traditional medicine in Nigeria. This study evaluated the anthelminthic, antiproliferative and antihypertensive potentials of R. vomitoria leaf methanol extract in Wistar rats. In addition, the phytochemical, acute toxicity, total phenolic and flavonoid contents were also evaluated. Results: Qualitative phytochemical screening revealed the presence of various metabolites with flavonoids and alkaloids the most predominant, with different amount of total phenolic and flavonoid contents per gallic acid and rutin equivalent respectively. NMR and GC-MS studies on the R. vomitoria showed the presence of methyl stearate ester a fatty acid ester. In vitro antioxidant activity by inhibition of DPPH and H2O2 scavenging radicals showed an IC50 value of 1.614 mg/mL and 0.101 mg/mL Acute toxicity investigation showed that extract is well tolerated at doses up to 5,000 mg/kg body weight RVE after two weeks. Anthelminthic and antiproliferative effects of the RVE showed dose-dependent activities in time of paralysis/death of earthworms and growth of guinea corn radicles respectively. The blood pressure reduced significantly in normotensive and RVE-treated hypertensive rats in dosedependent fashion. There was significant dilation of the aortic blood vessel at high concentration of RVE with reduced heart rate and complete blockage of adrenaline and CaCl2 stimulatory effects. Conclusions: This study provided the justification that R. vomitoria leaf extract possessed anthelminthic, antiproliferative and antihypertensive potentials, hence, its use as an ethnomedicinal prescription for these conditions in traditional medicine. It further provides an avenue for new drug discovery.

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Antihyperglycemic, antidyslipidemic and antioxidant properties of hydromethanol extract of Eremomastax speciosa leaf in alloxan monohydrate-induced hyperglycemic rats

Cited by 2 publications

References 31 publications

Therapeutic potential of concurrent administration of Hippocratea africana and Eremomastax speciosa in the treatment of Plasmodium berghei infected mice

Therapeutic potential of concurrent administration of Hippocratea africana and Eremomastax speciosa in the treatment of Plasmodium berghei infected mice

Evaluation of in vitro anthelminthic, antiproliferative and antihypertensive potentials of Rauwolfia vomitoria Afzel. (Apocynaceae) leaf extract

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