Antihyperglycemic, antihyperlipidemic and antioxidant activities of traditional aqueous extract of Zygophyllum album in streptozotocin diabetic mice

Ghoul, J. El; Smiri, Moêz; Ghrab, Saad; Boughattas, Naceur A.; Ben‐Attia, Mossadok

doi:10.1016/j.pathophys.2011.12.001

Cited by 37 publications

(20 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, it has been reported that auto oxidation of glucose in diabetes mellitus is major cause for generating oxidative stress [24]. Hyperglycemia is a well-known cause for elevated free radical concentration and this can lead to increased lipid peroxidation (TBARS), in tissues and blood of STZ-induced diabetic rats [25]. Our study showed that in the diabetic group in comparison with …”

Section: Plasma Rbcs (Red Blood Cells) and Tissues Lipid Peroxidationsupporting

confidence: 47%

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

Guenzet¹,

Krouf²,

Berzou³

2017

JPP

View full text Add to dashboard Cite

Abstract:The aim of this study was to investigate the antihyperglycemic and antioxidant effects of Po (Portulaca oleracea) lyophilised aqueous extract in diabetic male Wistar rats. Diabetes was induced intraperitonially by a single injection of STZ (streptozotocin) (60 mg/kg bw (body weight)). Twenty diabetic rats, weighing 263 ± 5 g, were divided into two groups fed a casein diet supplemented or not with Po extract (1 g/kg bw), for four weeks. Control group (n = 6) received 0.23~0.25 mL of citrate buffer and was fed a standard diet during the experiment. The study was carried out at Oran University, Algeria and the entire experiments lasted from September 2011 to July 2012. Blood was obtained from the abdominal aorta of rats after fasting overnight and standard methods were used for the extraction of spices, determination of glycemia, insulinemia, lipid peroxidation and antioxidant enzymes activities. Portulaca oleracea treated compared to untreated rats, glycemia and HbA1c values were respectively 2.8-and 1.7-fold lower. TBARS (thiobarbituric acid reactive substances) concentrations were reduced in RBC (red blood cells) (−54%) and plasma (−65%). Moreover, in liver and kidney, TBARS values were respectively 1.8-and 2-fold lower. SOD (superoxide dismutase) and GSH-Px (glutathione peroxidase) activities were increased respectively by +38% and +85%, in liver. GSSG-Red (glutathione reductase) activity was 1.9-fold higher in kidney, while CAT (catalase) was improved in kidney (+48%). In RBCs, SOD, GSH-Px, GSSH-Red and CAT activities were increased by 31%, 42%, 56% and +50%, respectively. These data have cast a new light on the actions of Portulaca oleracea and its antioxidant potential benefits in preventing diabetes and its complications.

show abstract

Section: Plasma Rbcs (Red Blood Cells) and Tissues Lipid Peroxidationsupporting

confidence: 47%

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

Guenzet¹,

Krouf²,

Berzou³

2017

JPP

View full text Add to dashboard Cite

show abstract

“…An important feature of diabetes is the shift in the fuel usage from carbohydrate to fats [1]. Diabetes mellitus is one of the five leading causes of death in the world [2]. Diabetes is referred as a common metabolic disease, which leads to 0928-4680/$ -see front matter © 2014 Elsevier Ireland Ltd. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

The calpain system and diabetes

et al. 2014

View full text Add to dashboard Cite

“…In conditions of diabetes, a multifarious number of studies have demonstrated that there is an alteration of lipid profiles indicating a risk factor for CVD [72] [73]. Ghoul et al, has revealed that insufficiency in insulin or the insulin resistance may be accountable for dyslipidemia on account of the insulin inhibiting action on the major enzyme in the cholesterol biosynthesis [74]. High levels of TC and more importantly LDL-cholesterol in blood are dominant coronary risk factors.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i> Asparagus racemosus</i> Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

Mamun¹,

Hossain²,

Islam³

et al. 2017

View full text Add to dashboard Cite

In recent years, the popularity of medicinal plants as a remedy has been increased manifold due to having minimal adverse effects. The current study aimed to compare the hypoglycemic, hypolipidemic and hepatoprotective effects of the ethanolic extract of Asparagus racemosus (EEAR) Linn. alone and combinedly with conventional antidiabetic agents (gliclazide and pioglitazone) in alloxan-induced diabetic rats. Diabetes was induced in male Wister albino rats by the administration of single intra-peritoneal injection of alloxan monohydrate (120 mg/kg b.w.). Effect of oral administration of two different doses of EEAR (200 and 400 mg/kg b.w.), gliclazide (10 mg/kg b.w.) and pioglitazone (10 mg/70kg/b.w.) alone for 2 weeks and a combination of EEAR (200 mg/kg b.w.) with either gliclazide (10 mg/kg b.w.) or pioglitazone (10 mg/70kg/b.w.) for 2 weeks were examined on hypoglycemic activity on 0 treatment as compared to that of disease control rats, gliclazide treated rats and pioglitazone treated rats. Proposed adjunct therapy also markedly (p < 0.001; p < 0.01, p < 0.001) improved serum TG, HDL and LDL level with insignificant change in VLDL and TC level while comparing with groups receiving gliclazide treated rats and pioglitazone treated rats. Administration of different doses of EEAR markedly (p < 0.05, p < 0.01, p < 0.001; p < 0.05, p < 0.01; p < 0.05) reduced the activity of TC, TG, LDL, VLDL and HDL cholesterol levels in a dose-dependent approach with respect to that of gliclazide treated rats and pioglitazone treated rats. The effect of combination therapy significantly (p < 0.001; p < 0.001; p < 0.01, p < 0.001) decreased the SGOT, SGPT and TP hepatic enzyme levels when compared to disease control rats, gliclazide treated rats and pioglitazone treated rats indicated improvement in liver dysfunctions. Administration of different doses of EEAR noticeably (p < 0.05, p < 0.01, p < 0.001; p < 0.05, p < 0.01; p < 0.05, p < 0.01) reduced the liver enzymes level including SGOT, SGPT and TP in a dose-dependent manner as compared to the disease control rats, gliclazide treated rats and pioglitazone treated rats. The maximum survival rate (100%) was observed in rats of combination treated rats. No significant changes in the body weight and organ weight to body weight ratio were observed except the groups that were given combined therapy showed improvement in the liver and pancreas weight. Our study suggests that the EEAR potentiates the activity of gliclazide and pioglitazone in controlling blood glucose levels, modifies the lipid profile and improves in liver dysfunction on alloxan-induced diabetic rats.

show abstract

Antihyperglycemic, antihyperlipidemic and antioxidant activities of traditional aqueous extract of Zygophyllum album in streptozotocin diabetic mice

Cited by 37 publications

References 43 publications

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

The calpain system and diabetes

Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i> Asparagus racemosus</i> Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

Contact Info

Product

Resources

About

Antihyperglycemic, antihyperlipidemic and antioxidant activities of traditional aqueous extract of Zygophyllum album in streptozotocin diabetic mice

Cited by 37 publications

References 43 publications

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

Portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-Induced Diabetic Wistar Rats

The calpain system and diabetes

Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of&lt;i&gt; Asparagus racemosus&lt;/i&gt; Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

Contact Info

Product

Resources

About

Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i> Asparagus racemosus</i> Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats