The mistletoe is a group of plants that is made up of more than 1300 species, which grow in a diverse number of environments; worldwide; with exception of Antarctica; and areas of extremely dry or cold weather from which they are not able to grow. All of them share a common form to grow. This form is known as obligate hemiparasitism that works with an organ called the haustorium; from which they can absorb water and mineral salts from their hosts. For this reason, it is known that these types of plants are rich in polyphenolic compounds with several biological activities. This group is made up by five families within the Santales. The Loranthaceae and Viscaceae families are well studied and distributed throughout the world, Europe, the Americas, Africa, Asia, and Australia. These families comprise the majority (> 98%) of mistletoe species. Mistletoe has been used as a medical treatment for various diseases in traditional medicine. They have been used to treat diseases like cancer, immunomodulatory diseases, cardiac diseases, hepatoprotective diseases, neuropharmacological diseases, besides of having found antibacterial and antifungal activities within them. The objective of this review is to focus on the research on the antidiabetic, antioxidant, and antiinflammatory properties of different species of mistletoe since diabetes is a growing global health problem. Further and deeper research will be needed to determine solvent type and which chemical compounds are responsible for biological activities. As a result, mistletoe could become a source of new therapies that support diabetes treatments.