Antihyperglycemic effect of esculetin modulated carbohydrate metabolic enzymes activities in streptozotocin induced diabetic rats

Myricetin modulates streptozotocin–cadmium induced oxidative stress in long term experimental diabetic nephrotoxic rats

“…Plants and its active compounds provide useful sources for the development of drugs in the treatment of diabetes mellitus (Karthikesan, Pari, & Menon, 2010;Prabakaran & Ashokkumar, 2012). The majority of the plants that are used in popular medicine for treatment of diabetes and its complications have been shown to possess biologically active chemical constituents (alkaloids, flavonoids, terpenoids, phenolic substances, and other constituents) that can be used as new hypoglycemic and hypolipidemic agents (Huang & Shen, 2012).…”

Trans-anethole, a terpenoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats

“…Fructose-1,6-bisphosphatase, a highly regulated rate-limiting enzyme that catalyzes dephosphorylation of fructose-1,6-bisphosphate to fructose-6-phosphate, the second to last step in the gluconeogenic pathway. It is abundant in liver and kidney but is scantly present in pancreatic b-cells under normal conditions [48]. Our study demonstrates that on administration of TA and glibenclamide, diabetic rats exhibited diminished activities of these two enzymes.…”

“…The restoration of hexokinase activity might be involved in normalization of glucose levels [47]. Hexokinase, an insulin dependent enzyme plays an important role by phosphorylating glucose to glucose-6-phosphate in the cell system [48]. However, modest increase in the activities of hexokinase was observed in diabetic rats treated with TA, protecting the hepatic and extrahepatic tissues against STZ-induced diabetes by stimulating insulin from existing b-cells, since STZ selectively destroys b-cells of pancreas.…”

β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats

“…PC and PEPCK catalyze the committed step in gluconeogenesis and are well poised to regulate hepatic glucose production. G6pase and F1, 6Bpase, gluconeogenic enzymes catalyze the irreversible steps in gluconeogenesis and serves as a site for the regulation of gluconeogenesis (Prabakaran and Ashokkumar, 2012). In the diabetic state, the deficiency of insulin enhances the activities of gluconeogenic enzymes resulting in endogenous glucose production.…”