Antihyperglycemic Effect of Rambutan Honey in Alloxan-induced Diabetic Wistar Rats

Rachmat, Iis Inayati; Yuslianti, Euis Reni; Permatasar, Githa F.; Koswara, Teja

doi:10.3923/jpt.2017.42.49

Cited by 8 publications

(7 citation statements)

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“…The observed glycaemic response of honey in diabetic rats might be attributed to the moderate doses of 10 ml/kg/day of 30% and 50% honey respectively used in our study. Notwithstanding, in the present study, the effect of Niger Delta honey orally compared with oral hypoglycaemic drug glibenclamide significantly reduced blood glucose concentrations in diabetic rats substantiating with the work by previous researchers [35,36]. Additionally, we also observed synergistic effect of natural honey by causing a further reduction in blood glucose levels when used in combination with oral hypoglycaemic drugs glibenclamide, than honey or glibenclamide alone in alloxan induceddiabetic rats which collaborates with the report of others [7].…”

Section: Treatmentssupporting

confidence: 93%

Prolonged Effect of Niger Delta Honey on Blood Glucose and Haematological Parameters in Alloxan Induced Diabetic Rats

Asuquo

Obia

Chuemere

2018

IJBCRR

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Diabetes mellitus is a metabolic condition that develops when the body fails to produce enough insulin or when insulin fails to work properly, is a global health problem. This study was conducted to evaluate the metabolic effect of eight-week administration of Niger Delta honey on the blood glucose, haematological parameters, body weight and glycosylated haemoglobin in alloxan-induced diabetic rats. Six groups of 8 rats each were used. Group I served as control; Group II was given 10ml/kg/day of the honey solution; Group III served as diabetic control; Group IV diabetic rats received 10ml/kg/day of the honey solution. Group V diabetic rats were given a single daily dose of 0.6 mg/kg glibenclamide. Group VI were treated with both glibenclamide and honey concurrently. The present study showed that honey significantly (p<0.05) improved blood cells and indices, body weight but caused marked decrease in blood glucose levels as well as glycosylated haemoglobin in alloxan diabetic rats. Furthermore, honey caused a further reduction in blood glucose levels when used in combination with glibenclamide. In conclusion, the result of the present study suggests that honey might prevent alloxan-induced anaemia, immune-disturbances, thrombocytopenia, weight Original Research Article

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Section: Treatmentssupporting

confidence: 93%

Prolonged Effect of Niger Delta Honey on Blood Glucose and Haematological Parameters in Alloxan Induced Diabetic Rats

Asuquo

Obia

Chuemere

2018

IJBCRR

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“…Rakhmat et al reported that the use of rambutan honey at a dose of 0.5 g kg -1 b.wt. was effective in reducing blood glucose levels in alloxan-induced rats [12].…”

Section: Introductionmentioning

confidence: 93%

The Effect of Rambutan Honey and Rutin on Decrease Blood Glucose and Increase Streptozotocin-Induced Rat Plasma Insulin

Rakhmat¹,

Yuslianti²,

Ratwita³

et al. 2022

Proceedings of the 13th Annual Scientific Conference of Medical Faculty, Universitas Jenderal Achmad Yani (ASCMF 2022)

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Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to insulin work disorders, insulin secretion disorders, or both. Rambutan honey as a natural ingredient has been studied to reduce oxidative stress, protect pancreatic beta cells from damage, and can increase insulin secretion from pancreatic beta cells. Rutin as secondary antioxidants can increase insulin secretion, reduce free radical formation, and can stimulate pancreatic progenitor cells to form new cells. This study aims to determine the effect of rambutan honey on blood glucose and insulin levels in rats induced by streptozotocin compared to rutin. This research is a pure experimental study with a total sample of 24 experimental animals consisting of 4 groups, namely negative control (NC), positive control (PC), and 2 treatment groups (T1-T2). Glucose levels were measured using the GOD-PAP method and were analyzed statistically (T-dependent p < 0.05, Anova, Duncan p < 0.05). Insulin levels were measured using a mouse insulin ELISA-kit and were statistically analyzed (Anova, Duncan p < 0.05). The results showed that rambutan honey and rutin could significantly reduce blood glucose levels (p = 0.008 and p = 0.010). Data on insulin levels showed significant differences between groups (p = 0.000). The conclusion of this study is that rambutan honey and rutin can reduce blood glucose level and increase insulin levels because they are antioxidant agents which have antihyperglycemic effects.

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“…Hasil penelitian pada tahap awal pada tikus diabetes melitus tipe II yang diinduksi oleh streptozotosin didapatkan bahwa madu rambutan dapat menurunkan 500 mg/kgBB sebesar 42,4 mg/dL dan menurunkan kadar kolesterol darah sebesar 30,78 mg/dl (Rakhmat, 2017) . Khasiat madu rambutan sebagai obat diabetes melitus telah dikenal namun belum diketahui dan diteliti kandungan zat aktif yang terkandung didalamnya sehingga studi bahan alam tersebut masih sangat terbuka luas.…”

Section: Pendahuluanunclassified

Isolasi Senyawa Aktif Flavonoid Rutin Madu Sebagai Metabolit Sekunder Bahan Baku Pengembangan Obat Diabetes Melitus

Rakhmat

Yuslianti

Alatas

2020

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Metabolit sekunder sebagai bahan baku pengembangan obat modern dibutuhkan terutama untuk penyakit kronis diantaranya diabetes melitus. Bahan alami berpotensi sebagai antidiabetes adalah madu rambutan yang mengandung flavonoid rutin dan diduga mampu melindungi sel beta pankreas dengan mengurangi stres oksidatif. Penelitian ini bertujuan mengisolasi komponen aktif flavonoid (rutin) dari madu rambutan sebagai bahan baku untuk pengembangan obat diabetes melitus. Penyiapan isolat dilakukan dengan mengekstraksi caircair madu diikuti dengan memfraksinasi dengan masing-masing pelarut air, n-heksana, dan etil asetat. Hasil fraksinasi dianalisis dengan kromatografi lapis tipis(KLT) pada plat prasalut Kiesel gel GF254. KLT preparatif dilakukan terhadap fraksi etil asetat menggunakan Plat Preparatif silica gel 60 GF254. Kemurnian Isolat diuji dengan KLT dua arah dengan menggunakan rutin trihidrat sebagai pembanding. Pola-pola kromatogram menunjukkan bahwa bercak senyawa hanya terdapat pada fraksi etil asetat. Hasil kromatogram uji kemurnian menunjukkan ada satu bercak di pengembangan pertama dan pengembangan kedua yang mengindikasikan bahwa isolat adalah senyawa murni rutin yang identik dengan pembanding.

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Antihyperglycemic Effect of Rambutan Honey in Alloxan-induced Diabetic Wistar Rats

Cited by 8 publications

References 0 publications

Prolonged Effect of Niger Delta Honey on Blood Glucose and Haematological Parameters in Alloxan Induced Diabetic Rats

Prolonged Effect of Niger Delta Honey on Blood Glucose and Haematological Parameters in Alloxan Induced Diabetic Rats

The Effect of Rambutan Honey and Rutin on Decrease Blood Glucose and Increase Streptozotocin-Induced Rat Plasma Insulin

Isolasi Senyawa Aktif Flavonoid Rutin Madu Sebagai Metabolit Sekunder Bahan Baku Pengembangan Obat Diabetes Melitus

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