Antihyperglycemic effects of the methanol leaf extract of Diaphananthe bidens in normoglycemic and streptozotocin–induced hyperglycemic rats

Ottah, Anaga Aruh; Augustine, O Okhamafe; Obiora, Igboeli Okechukwu; Maxwell, Ezeja

doi:10.1016/s1995-7645(12)60023-6

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…The filtrate was collected and stored in the refrigerator for use. A given quantity of the filtrate from the extraction was completely dried under vacuum and weighed; the residue was used to determine the percentage yield of the sample upon which the dosage was determined (OTTAH et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

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The effects of aqueous extracts of dried-pulverised or the fresh form of Talinum triagulare on the haematology and serum biochemistry of layers

et al. 2018

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Section: Methodsmentioning

confidence: 99%

“…The ground paste was left to stand for 48 hours and stirred for two hours for complete mixing. Thereafter, it was filtered with a domestic sieve cloth; the filtrate was collected and then kept in a refrigerator for the experiment (OTTAH et al, 2012). The percentage yield and dosage were determined as stated above.…”

Section: Methodsmentioning

confidence: 99%

The effects of aqueous extracts of dried-pulverised or the fresh form of Talinum triagulare on the haematology and serum biochemistry of layers

et al. 2018

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“…Group III and IV received ethanolic extracts of the plants at a dose of 200mg/kg and 400mg/kg respectively. Blood samples were collected from the tail veins of each animal at 0 hr, 1hr, 2 hr, 3 hr, 4 hr after feeding the plant extracts, and the blood glucose levels were determined using glucometer after collecting the blood from the tail vein 16 .…”

Section: Normoglycemic Studiesmentioning

confidence: 99%

Untitled

2016

IJPSR

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Ethanolic extract of the roots of Chonemorpha fragrans, a traditionally used antidibetic plant was evaluated for its antihyperglycemic and antihyperlipidemic effect using streptozotocin-nicotinamide induced diabetic rat model. Oral glucose tolerance test with 2g/kg of glucose and normoglycemic studies were performed which showed a dose dependant decrease in sugar levels. The acute oral toxicity studies demonstrated the safety of the dose up to 2000mg/kg body weight. The diabetic rats were treated with ethanolic root extracts, at a dose of 200mg/kg and 400mg/kg based on the acute toxicity study. Standard groups were treated with Glibenclamide at a dose of 0.6mg/kg. Treatment was continued for 21 days and the weights of the rats and serum glucose levels were measured on 1 st ,7 th ,14 th and 21 st day. Other biochemical parameters like lipid profile, HbA1c, ALT, AST, serum creatinine, urea and total proteins were evaluated on the last day of the study. The results of the study have shown a significant difference between the initial and final fasting blood glucose levels of C. fragrans and glibenclamide treated diabetic rats. These results justifies the traditional claim of the usefulness of C. fragrans root extract in the treatment of type 2 D. mellitus.

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“…Successive extraction of powdered plant materials were done by cold maceration using petroleum ether, chloroform, ethyl acetate and methanol as solvents 13 . In this method plant materials (500 gm) were continuously macerated in an air tight, clean flat bottomed glass container for 7 days at room temperature with occasional stirring and shaking.…”

Section: Preparation Of Extract and Activity Guided Fractionationmentioning

confidence: 99%

EHydrogel Formulation of Buchanania lanzan Spreng-A Focus on Rheological Properties

Pattnaik¹,

Mukherjee²,

Sarkar³

et al. 2015

IJDDT

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The aim of this study was to characterize and optimize the different hydrogel formulations of the methanolic root extract of Buchanania lanzan (MEBL) with an objective towards the development of a suitable topical delivery system. The gel formulations were prepared with different concentrations of polymer (Carbopol-940) and 0.5% of the active fraction (ethyl acetate sub-fraction of MEBL). Different hydrogel formulations were analyzed for rheological properties, spreadability, homogeneity and stability. A comparative study of rheological parameters, and spreadability showed that the gel formulations displayed all the desirable properties, which are considered to be essential prerequisites for a standard stable gel formulation. Based on the rheological studies of all the formulations, sample F3 was found to be a stable formulation with comparatively superior rheological characteristics.

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Antihyperglycemic effects of the methanol leaf extract of Diaphananthe bidens in normoglycemic and streptozotocin–induced hyperglycemic rats

Abstract: D. bidens extract possess antihyperglycemic activity which may be mediated through pancreatic and extra-pancreatic pathways, thereby justifying it folkloric use.

Cited by 11 publications

References 25 publications

The effects of aqueous extracts of dried-pulverised or the fresh form of Talinum triagulare on the haematology and serum biochemistry of layers

The effects of aqueous extracts of dried-pulverised or the fresh form of Talinum triagulare on the haematology and serum biochemistry of layers

Untitled

EHydrogel Formulation of Buchanania lanzan Spreng-A Focus on Rheological Properties

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