An extensive study was conducted on the methanolic extracts of two plants namely, Breynia disticha and Vernonia elaeagnifolia aiming to identify their antipyretic, hypoglycemic and irritant activities. Antipyretic effect was studied using milk induced pyrexia in rabbits whereas hypoglycemic effect was studied using glibenclamide as a standard drug in rabbits. In case of both studies the results were found to be significant (P<0.05). No irritant effect was observed on the rabbit’s ear. The studies show the plants to be of wide and significant medicinal importance.