Antihyperlipidemia Effects of Jengkol Leaf Extract (Archidendron jiringa)

Abstract

This Jengkol is one of the native plants in Indonesia. Jengkol beans are known as a popular food ingredient, and empirically the leaf is also used by people to treat hyperlipidemia. This study aimed to determine the antihyperlipidemic effect of Jengkol leaf extract (Achidendron jiringa) on male white rats induced by propylthiouracil and High fat diet. This was an experimental research with complete random design. Animals were divided into 5 groups: negative control group (tween 80), positive control (simvastatin 10 mg/kg BW), 3 other groups were given Jengkol leaf extract a dose of 100, 200, and 400 mg/kg BW. The result showed that there is a significant decline in total cholesterol levels after being given Jengkol leaf extract for 14 days at each dose respectively compared to the hyperlipidemic group. The percentages were 41.45%, 47.76%, 44.91%, and the simvastatin group was 56.70%. The study also revealed the optimal dose of Jengkol leaf extract that was 200 mg/kg BW