Antihyperlipidemic Activities of Isolated bio Compounds of Aegle Marmelos

Abstract

The present work was done to study qualitative investigation of extractability of the useful compounds from Aeglemarmelos leaves via supercritical fluid extraction technique (SFE) and to evaluate antihyperlipidemic activity of Aeglemarmelos(Am).The obtained extract and fractions were treated on Triton induced rat models and the results showed lowering the lipid profile levelin the experimental models by in-vivo methods. The fractions of Aeglemarmelos(AmF1) also exhibited excellent anti hyperlipedimic property at 3 rd week and also lowering the serum cholesterol, triglycerides in Triton induced rats. The most important ingredients present in plant communities turn out to be alkaloids, terpenoids, steroids, phenols glycosides and tannins are responsible for monitoring the normal lipid profile in Triton induced rats due to LA of lecithin acetyl transferase (LCAT), which regulates lipids concentration. The LCAT plays a key role in the incorporation of free cholesterol into HDL (this may increase HDL) and transferring it back to VLDL and LDL which are taken back later in liver cells.The changes in the level of serum lipids in experimental rats areillustrated in (Table 1). The total Cholesterol, TG1, LDL and VLDC significantlydecreased (P<0.001) and simultensely there is increase in level of HDLs.Supercritical Fluid extraction of leaves of Aeglemarmelos(Am)possess significantantihyperlipidemic activity as compared to control group.