Antihyperlipidemic Effect of Crocin Isolated from the Fructus of Gardenia jasminoides and Its Metabolite Crocetin

Lee, In Ah; Lee, Jin Hee; Baek, Nam In; Kim, Dong Hyun

doi:10.1248/bpb.28.2106

Cited by 207 publications

(121 citation statements)

References 18 publications

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“…The most potent inhibitor was crocetin, with an IC 50 value of 2.1 mg/mL. 109 In mice fed a high fat diet, crocetin and crocin inhibited the incremental increase in body weight compared with that of the control group. These compounds also significantly reduced epididymal fat pad mass.…”

Section: Crocin and Crocetinmentioning

confidence: 97%

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

Tucci¹

2010

DMSO

123

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Section: Crocin and Crocetinmentioning

confidence: 97%

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

Tucci¹

2010

DMSO

123

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“…Apoptosis and necrosis are important modes of neuronal death induced by cerebral ischemia, but in recent years a third method of death, autophagy, has been studied [1][2][3] . Autophagy, which involves the formation of autophagosomes and autophagolysosomes, has been studied extensively as a caspase-independent cell death pathway and has been associated with ischemia and reperfusion in the heart and brain [4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

Zheng

Liu

et al. 2009

Acta Pharmacol Sin

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Aim: To test the role of the Beclin 1-dependent autophagy pathway in brain damage during cerebral ischemia. Methods: Focal cerebral ischemia was established in rats using a middle cerebral artery occlusion (MCAO) model. A lentiviral vectorassociated RNA interference (RNAi) system was stereotaxically injected into the ipsilateral lateral ventricle to reduce Beclin1 expression. We measured the ipsilateral infarct volume, autophagosome formation, neurogenesis and apoptosis, all of which could be modulated by Beclin1 RNAi. Results: On the 14th day after MCAO, Beclin1 downregulation by RNAi increased the population of neural progenitor cells (BrdU + -DCX + ), newborn immature cells (BrdU + -Tuj-1 + ) and mature neurons (BrdU + -MAP-2 + ), and reduced the apoptosis of immature neurons (caspase-3 + -DCX + and caspase-3 + -Tuj-1 + ) surrounding the ischemic core of the ipsilateral hemisphere. Furthermore, RNAi-mediated downregulation of Beclin1 decreased infarct volume and inhibited histological injury and neurological deficits. Conclusion: RNAi-mediated downregulation of Beclin1 improves outcomes after transient MCAO.

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“…Due to its antioxidant property, crocin may be used as a pharmacological agent in cases that results in cerebral ischemia (Lee et al 2005). The modern pharmacological studies have shown that saffron extract and active contents of it have anti-tumor effects, radical scavenger properties, hypolipemic effect and memory-improving effect (He et al 2005;Sugiura et al 1994;Zhang et al 1994).…”

Section: Discussionmentioning

confidence: 99%

Neuro-protective effects of Crocin on brain and cerebellum tissues in diabetic rats

Altinzo¹,

Oner²,

Elbe³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Increase in free oxygen radicals and the disruption of defense system make the neurons and astrocytes more sensitive against oxidative damage. Materials and Methods: Rats were divided into three groups containing 10, rats in each group namely: control (C) group, Diabetes Mellitus (DM) group, and Diabetes Mellitus + crocin (DM+crocin) group. Tissue samples were processed by routine histological and biochemical procedures. The sections were stained with Hematoxylen-eosin. Malondialdehyde (MDA), glutathione (GSH), blood glucose, HbA1c levels and xanthine oxidase (XO) activities were assayed. Results: The histological appearence of the cerebrum and cerebellum were normal in the control group. DM group showed some histopathological changes including congestion, perivascular and perineuronal edema in cerebrum. In DM + crocin group, histopathological changes in cerebrum and cerebellum markedly reduced. MDA level and XO activities increased significantly in DM group (P<0.01), but decreased significantly in DM + crocin group when compared to DM group (P<0.01). Blood glucose concentrations increased significantly (p<0.01) in DM group), but decreased significantly in DM + crocin group when compared with DM group (p<0.05). Blood HbA1c levels were normal in control group. But there were significant differences between control and DM groups (p<0.01). On the other hand, blood HbA1c levels decreased in DM+crocin group when compared with the DM group, but it was not statistically significant (p > 0.05). Conclusion: Due to the fact that crocin has an antioxidant and anti-hyperglycemic effects, it can protect the brain and cerebellum tissue against the complications of oxidative stress.

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Antihyperlipidemic Effect of Crocin Isolated from the Fructus of Gardenia jasminoides and Its Metabolite Crocetin

Cited by 207 publications

References 18 publications

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

Neuro-protective effects of Crocin on brain and cerebellum tissues in diabetic rats

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