Antihyperlipidemic Effects of Salvia officinalis L. Leaf Extract in Patients with Hyperlipidemia: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial

Abstract

Hyperlipidemia is a common metabolic disorder contributing to morbidities and mortalities due to cardiovascular and cerebrovascular diseases. Conventional antihyperlipidemic drugs have limited efficacies and important side effects, so that alternative lipid lowering agents are needed. Salvia officinalis L. (sage) leaves have PPAR γ agonistic, pancreatic lipase and lipid absorption inhibitory, antioxidant, lipid peroxidation inhibitory and antiinflammatory effects. Thus, in this randomized double-blind placebo-controlled clinical trial with 67 hyperlipidemic (hypercholesterolemic and/or hypertriglyceridemic) patients aged 56.4 ± 30.3 years (mean ± SD), the effects of taking sage leaf extract (one 500 mg capsule every 8 h for 2 months) on fasting blood levels of lipids, creatinine and liver enzymes including SGOT and SGPT were evaluated in 34 patients and compared with the placebo group (n = 33). The extract lowered the blood levels of total cholesterol (p < 0.001), triglyceride (p = 0.001), LDL (p = 0.004) and VLDL (p = 0.001), but increased the blood HDL levels (p < 0.001) without any significant effects on the blood levels of SGOT, SGPT and creatinine (p > 0.05) compared with the placebo group at the endpoint. No adverse effects were reported. The results suggest that sage may be effective and safe in the treatment of hyperlipidemia.

Phytochemical characterization and effect of Calendula officinalis, Hypericum perforatum, and Salvia officinalis infusions on obesity-associated cardiovascular risk

“…Herbal infusions were able to modulate serum lipoproteins and total lipids, indicating their potential in cardiovascular risk prevention. Similar results have been previously reported for a S. officinalis aqueous extract, which helped to improve lipid profile in healthy and hyperlipidemic humans (Sá et al, 2009;Kianbakht et al, 2011). Likewise, a dried hydro-alcoholic extract from H. perforatum reduced serum TC, LDL-c, and TG levels and increased HDL-c levels in both high-fructose-and high-fat-fed rats (Husain et al, 2011).…”

Evaluation of the Effects of Pinus koraiensis Needle Extracts on Serum Lipid and Oxidative Stress in Adults with Borderline Dyslipidemia: A Randomized, Double‐Blind, and Placebo‐Controlled Clinical Trial

“…Sample size was estimated based on the results from a previous trial [10], where the detection of a significant difference between groups ( α = 0.05 and β = 0.80) allowing for a 25% dropout rate suggested the recruitment of 35 people into each group.…”

Herbs for Diabetes: Update—Part 2

“…56 A typical dose of the tea is 3-5 g (1 tbsp) of herb per cup (200 mL) of hot water steeped for 15 minutes; 3 cups per day are consumed. A typical dose of tincture is 2-3 mL t.i.d.…”