Antihyperlipidemic Effects of Sour Cherries Characterized by Different In Vitro Antioxidant Power and Polyphenolic Composition

Papp, Nóra; Blázovics, Anna; Fébel, Hedvig; Salido, Sofı́a; Altarejos, Joaquı́n; Fehér, Erzsébet; Kocsis, Ibolya; Szentmihályi, Klára; Abrankó, László; Hegedűs, Attila; Stefanovits-Bányai, Éva

doi:10.1007/s11130-015-0509-2

Cited by 15 publications

(9 citation statements)

References 31 publications

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“…In our experiments, several plant extracts of natural origin, such as Raphanus sativus niger, Sempervivum tectorum Cichorium intibus, Taraxacum officinale, Helichrysum arenarium, Peroselium crispum, Anthriscus cerefolium lyophilized extracts, Solidago canadensis and alcoholic and aqueous extracts of Ginkgo biloba . Hibiscus sabdariffa , Beta vulgaris var rubra as well as silibinin and silymarin compounds or fruits, apples sour cherries were investigated [7,12,18,19,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] .…”

Section: Medical Biochemical Research At Hungary (Semmelweis University)mentioning

confidence: 99%

Regulation of Herbal Medicine in Hungary

Hegyi

Blázovics

2020

CEI

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In order to meet the growing needs of the European Union medicinal and aromatic plants, Hungary is still one of the major exporters today, although earlier, until the 1980s, we were considered a great herb-growing nation. Therefore, the development of the national medicinal and aromatic herb growing sector is an essential requirement for maintaining and developing our market position. The natural conditions of Hungary favor the cultivation of medicinal and aromatic plants. There are more than 330 herbs in our country. About seventy percent of the drugs grown and harvested are exported. However, significant changes are needed in domestic sales and further processing in order to become a leading industrial sector. Hungary also possesses modern separation techniques and large instruments for analysis, which allow the proper analytical examination of drugs and the precise determination of their active substances. Our universities and research institutes are also prepared to study the active ingredients of herbs by molecular biological methods, which may allow the exact mechanism of action of bioactive substances to be determined and the herbs to be reassessed. Our accession to the European Union the palette of products made from former herbs has significantly changed. From 2013, the category of medicinal product was discontinued, and the preparations were classified as either food or medicine. However, there are significant costs associated with qualifying as a drug, so drugs or extracts are largely added to dietary supplements. As a result, the strange situation is that dietary supplements are prohibited from making any health claims, even though the dietary supplement is actually not for the benefit of a healthy population, but for those who have a health problem or do not have suitable foods, which are rich in bioactive substances. The justification of phytotherapy must be demonstrated, depending on the state of the art. In the context of safe therapy, studies must follow the requirements of medicines and only then can they become herbal medicines. There is still much to be desired in this area in our country. Classification as a drug is based on expensive animal tests and clinical studies. A new problem arises here, as herbal cure is currently part of the arsenal of complementary medicine. With few exceptions, clinical doctors do not use herbal therapies. Patients usually ask the advice of pharmacists, naturalists, and more rarely, dietitians. At the Arteriosclerosis Research Group, at the II. Department of Medicine and Institute of Pharmacognosy several decades of biomedical research have served and serve the purpose of evaluating and reassessing the effects of plants used in folk medicine. Over the years, we have been searching for drugs, extracts, and medicines of natural origin that are useful in liver and intestinal diseases known in folk medicine, and are believed to have lipid lowering, antioxidant and immune stimulating effects. In the article, animal and human studies will be also presented.

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Section: Medical Biochemical Research At Hungary (Semmelweis University)mentioning

confidence: 99%

Regulation of Herbal Medicine in Hungary

Hegyi

Blázovics

2020

CEI

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“…A genisztein-7-O-β-glükozid 0,5-5,8 mg/kg frisstömeg-koncentrációban volt kimutatható. A 'Fanal' meggy fajta esetében az antocianintartalom bizonyult kiemelkedőnek [29].…”

Section: A Meggy Polifenolos Vegyületeinek Jellemzése éS Helye a Csonunclassified

“…Papp és mtsai [29] a meggy in vivo fiziológiai hatásának vizsgálatához hím Wistar-patkányokat használtak, melyeket négy csoportba osztottak, csoportonként 5-5 ál-lattal. Az alimentáris zsírmájat a hagyományos táp 1% koleszterinnel, 11% napraforgóolajjal és 0,3% kólsavval történő kiegészítésével érték el.…”

Section: Különböző Meggyfajták Gyümölcsének Hyperlipidaemia Elleni Véunclassified

“…Papp és mtsai [29] eredményeinek újdonsá-ga abban rejlik, hogy bizonyítják: a különböző mennyiségű polifenolt felhalmozó meggyek fiziológiai hatása eltérő. Ugyanakkor érdekes további vizsgálatokra ad alapot az a tény, hogy a nagy antocianintartalmú 'Fanal' és az antocianinban szegény, de más polifenolokban (izoflavonoidok, fenolos savak) gazdag 'Pipacs 1' kedvező hatása gyakorlatilag azonos mértékűnek bizonyult vizsgálatunkban.…”

Section: Különböző Meggyfajták Gyümölcsének Hyperlipidaemia Elleni Véunclassified

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A különleges és egyedi polifenol-összetételű meggy egészségi hatásai

et al. 2018

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A gyümölcsök kedvező egészségi hatását egyre több tanulmány támasztja alá, ami elsősorban a gyümölcs héjában és húsában akkumulálódó polifenolos vegyületeknek tulajdonítható. Ezek transzkripciós, poszttranszkripcionális és epigenetikai szintű hatása egyaránt bizonyított. Mivel a gyümölcsfogyasztás mértéke világszerte elmarad az ajánlott mennyiségtől, egy új megközelítés a kedvező vegyületekben gazdagabb, úgynevezett szupergyümölcsök fogyasztását javasolja. A magyar gyümölcsfajták összehasonlító vizsgálata kimutatta, hogy ugyanazon faj fajtái (eltérő genotípu-sok) között jelentős mértékű variabilitás jelentkezik számos polifenolos vegyületcsoport mennyiségében. Azonosítot-tunk olyan meggygenotípusokat (például 'Pipacs 1' és 'Fanal'), melyek összes polifenoltartalma jelentősen meghaladja a többi fajtára jellemző értékeket. A különböző meggyfajták eltérő polifenoltartalmú gyümölcseinek fiziológiai hatását alimentáris eredetű hyperlipidaemiás modellen, hím Wistar-patkányokon vizsgáltuk. A meggyfogyasztás fajtánként eltérő következménnyel járt: a 'Pipacs 1' és a 'Fanal' már 10 napos kezelést követően több, mint 30%-kal mérsékelte a vérplazma összkoleszterinszintjét, míg az 'Újfehértói fürtös' nem okozott szignifikáns csökkenést. A két előbbi fajta kedvező hatása a szérum más lipidparamétereiben és a máj hisztológiai vizsgálata során is kimutatható volt. Ezen eredmények alapján nemcsak néhány bogyós és trópusi gyümölcs tekinthető szupergyümölcsnek, hanem a csonthéjas gyümölcsök bizonyos genotípusai is. Ezek valóban markánsabb fiziológiai hatást gyakorolnak. Mivel a 'Pipacs 1' színtelen polifenolokban (például fenolsavak, izoflavonoidok), a 'Fanal' antocianinokban gazdag, az alimentáris eredetű zsírmájjal szembeni védőhatásban több, különböző polifenolos vegyület szerepe valószínűsíthető. Orv Hetil. 2018, 159(18): 720-725.Kulcsszavak: antocianin, genisztein, gyümölcsfogyasztás, meggy, polifenolok Health effects of sour cherries with unique polyphenolic composition in their fruitsHealth effects of fruit consumption are confirmed by many studies. Such effects are attributed to the polyphenolic compounds accumulating in fruit skin and mesocarp tissues. They contribute to the regulation on transcriptional, post-transcriptional and epigenetic levels. Since people consume much less fruits than the recommended quantities, a new approach includes the promotion of super fruits that are extremely rich sources of specific health compounds. A comparative analysis of Hungarian stone fruit cultivars detected a huge variability in fruit in vitro antioxidant capacity and total polyphenolic content. Two outstanding sour cherry cultivars ('Pipacs 1' and 'Fanal') were identified to accumulate elevated levels of polyphenolic compounds in their fruits. Sour cherries with different polyphenolic compositions were tested against alimentary induced hyperlipidemia using male Wistar rat model. Consumption of cherry fruit had different consequences for different cultivars: consumption of 'Pipacs 1' and 'Fanal' fruits resulted in 30% lower total c...

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“…Many studies have been conducted to evaluate their properties in terms of quality and bioactivity. (Kim et al 2005;Hegedűs et al 2013;Papp et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and biochemical parameters of four sweet cherry (Prunus Avium L.) cultivars grown in agro-ecological conditions of middle Atlas of Morocco

Baji¹,

Kodad²,

Hanine³

et al. 2019

LSJ

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Theobjective of thisstudyis to investigate the phenotypic and biochemicalparameters of selectedsweet cherry (Prunus avium) from middle region of Morocco. Themain biochemical composition, contentsof total polyphenols, total flavonoids, total anthocyanins and antioxidant activity, were measured in the fruits of four sweet cherry cultivars (ʻBurlat’, ʻVan’, ʻNapoleon’andʻCerisette’) grown in two locations (“Laanoceur”and “Toufselt”) in the MiddleAtlas. The free radical scavenging activity was evaluated spectrophotometrically using 1,1‒diphenyl‒2‒picrylhydrazine (DPPH)and ABTS assay.The fruit weight, and pulppercentagewerestudied and found to range between 237–329 g, 38.14–42.22%, 39.21–44.36g, and 52.27–57.48%, respectively.The total phenolic and total anthocyanin content rangedfrom305.99 and 306.67 mg EqGal/100g D.W, total flavonoid contents were within the range of 481.73-517.67 mgeqRE/100g D.W, and total anthocyanin contents were between 1.09 and 2.89 mg Eqcyanidin 3-glucoside/100g D.W. Antioxidant activity ranged from 17.18 to 18.11 mg EqTrolox/100g D.W for DPPH assayand from 27.97 to 29.60 mg EqTrolox/100f D.W for ABTS method.The highest values of total anthocyanin content and antioxidant activity (DPPH) were recorded in ʻBurlat’. The highest value of total flavonoid content was found in ʻCerisette’. Cherries from “Laanoceur”and “Toufselt” locations are characterized by similar biochemical composition and antioxidant activity, except for total anthocyanin content that shows slightly elevated values in “Laanoceur”. The close correlation between total phenolic contents and antioxidant activities (r2=0.73) show that antioxidant activity of cherry fruit depends on total polyphenols.

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Antihyperlipidemic Effects of Sour Cherries Characterized by Different In Vitro Antioxidant Power and Polyphenolic Composition

Cited by 15 publications

References 31 publications

Regulation of Herbal Medicine in Hungary

Regulation of Herbal Medicine in Hungary

A különleges és egyedi polifenol-összetételű meggy egészségi hatásai

Phenotypic and biochemical parameters of four sweet cherry (Prunus Avium L.) cultivars grown in agro-ecological conditions of middle Atlas of Morocco

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