Antihypertensive Activity and Anti-gout Activity of Mushroom Sarcodon aspratus

강민구,; Bolormaa, Zanabaatar; 이종석,; Seo, Geon-Sik; Lee, Jong-Soo

doi:10.4489/kjm.2011.39.1.053

Cited by 18 publications

(8 citation statements)

References 10 publications

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“…많은 버섯들이 성 인병 치료와 예방에 관련된 생리활성 물질을 함유하고 있 는 것으로 알려져 있다. 상황버섯 (Choi et al, 1996)과 구 름버섯 (Tsukagoshi and Ohashi, 1974)의 다당류가 항암물 질로 알려져 있으며, 능이 (Kang et al, 2011)의 항고혈압 성 활성과 차가버섯의 혈소판 응집 저해활성 (Hyun et al, 2006)이 확인되었으며, 팽이 (Shin and Choi, 1998)와 할 미송이버섯 (Kim and Kim, 2001)으로부터 활성이 큰 혈 전용해효소와 석이로부터 혈당강하 효과가 큰 물질이 확 인되었다 (Choi et al, 2000). 한국인의 사망원인 중 가장 큰 비율을 나타내는 악성 종양의 원인 중 하나로 알려진 활성산소는 정상세포에 반 응하여 암이나 노화세포로 발전시키는 것으로 알려져 있다.…”

Section: 서 론unclassified

Biological Activities of Water Extract and Solvent Fractions of an Edible Mushroom, Hericium erinaceus

Kim¹

2012

The Korean Journal of Mycology

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: This study was performed to investigate the biological activities of Hericium erinaceus fruiting body, including antioxidative, fibrinolytic, thrombin inhibitory and α-glucosidase inhibitory activities. The water extract of H. erinaceus was fractionated into hexane, chloroform, ethyl acetate, butanol and water fractions, and each of these fractions was individually assayed. The water extract showed high antioxidative activity at 87.78%. The water fraction showed the highest extraction yield at 35.68% (w/w). In the fraction activity tests, butanol and water fractions showed strong antioxidative activities at 87.91% and 92.27%, respectively. Assays for fibrinolytic activity indicated that only the ethyl acetate fraction has significant efficacy at 2.96 plasmin units/mL. The 10-fold dilution of hexane fraction showed high thrombin inhibitory activity, and α-glucosidase inhibitory activity at 77.67% and 90.53%, respectively. In conclusion, solvent fractions of H. erinaceus can be used as materials for the development of biofunctional foods to prevent cardiovascular diseases.

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Section: 서 론unclassified

Biological Activities of Water Extract and Solvent Fractions of an Edible Mushroom, Hericium erinaceus

Kim¹

2012

The Korean Journal of Mycology

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“…It is believed that XOD inhibitors from natural sources can be used as alternatives to allopurinol because of fewer potential adverse side effects [ 11 ]. Many XOD inhibitors have been isolated and characterized from plants [ 12 , 13 ] and mushrooms [ 13 , 14 , 15 , 16 , 17 ]. However, to date they have not been used for the treatment of gout because of their low XOD inhibitory activity.…”

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Characterization of an Anti-gout Xanthine Oxidase Inhibitor from Pleurotus ostreatus

et al. 2014

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We selected Pleurotus ostreatus from among several edible mushrooms because it has high anti-gout xanthine oxidase (XOD) inhibitory activity. The maximal amount of XOD inhibitor was extracted when the Pleurotus ostreatus fruiting body was treated with distilled water at 40℃ for 48 hr. The XOD inhibitor thus obtained was purified by Sephadex G-50 gel permeation chromatography, ultrafiltration, C18 solid phase extraction chromatography and reverse-phase high-performance liquid chromatography with 3% of solid yield, and its XOD inhibitory activity was 0.9 mg/mL of IC50. The purified XOD inhibitor was a tripeptide with the amino acid sequence phenylalanine-cysteine-histidine and a molecular weight of 441.3 Da. The XOD inhibitor-containing ultrafiltrates from Pleurotus ostreatus demonstrated dose-dependent anti-gout effects in a Sprague-Dawley rat model of potassium oxonate-induced gout, as shown by decreased serum urated levels at doses of 500 and 1,000 mg/kg, although the effect was not as great as that achieved with the commercial anti-gout agent, allopurinol when administered at a dose of 50 mg/kg.

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“…버섯은 식용 및 약용으로 사용된 천연식품으로써 탄수화물, 단백질, 및 지질 등 각종 영양소를 함유하고 있으며, 암, 뇌졸 증, 및 당뇨병 등 성인병 예방과 치료에 사용되고 있다 [14][15][16] . Co., USA) 배지에 접종하여 24시간 동안 37℃ 혐기성 배양기 (5% CO 2 )에서 배양하였다.…”

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Antimicrobial activities against oral bacteria and growth inhibition against Actinomyces viscosus using Lentinus edodes various extracts

Han¹,

Lim²,

Oh³

2015

J Korean Soc Dent Hyg

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Objectives: Lentinus edodes is an edible mushroom with a variety of beneficial effects such as antitumor, anti-inflammatory, antioxidant, and immune-modulatory activity. This study was carried out to evaluate the antimicrobial activities of Lentinus edodes extracts against oral-related bacteria. Methods: The antimicrobial activities of this extracts were investigated against S. anginosus, S. sobrinus, S. aureus, S. mutans, S. ratti, S. sanguinis, A. viscosus, A. naeslundii, and A. actinomycetemcomitans by the disc diffusion method, minimum inhibitory concentration (MIC), and growth inhibition. Results: Ethanol extracts had no antimicrobial activities, but acetone extracts showed antimicrobial activities against A. viscosus and A. actinomycetemcomitans and ethyl acetate extracts had effects against S. aureus, S. sanguinis, A. viscosus, and A. actinomycetemcomitans. Conclusions: The inhibitory effect of Lentinus edodes extracts was investigated on the growth of A. viscosus. Ethyl acetate and acetone extracts showed 90% and 77% inhibitory effect, respectively, against A. viscosus for 24 hrs. Ethyl acetate extracts had MIC of 25.0 mg/ml and acetone extracts showed MIC of >25.0 mg/ml.

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Antihypertensive Activity and Anti-gout Activity of Mushroom Sarcodon aspratus

Cited by 18 publications

References 10 publications

Biological Activities of Water Extract and Solvent Fractions of an Edible Mushroom, Hericium erinaceus

Biological Activities of Water Extract and Solvent Fractions of an Edible Mushroom, Hericium erinaceus

Characterization of an Anti-gout Xanthine Oxidase Inhibitor from Pleurotus ostreatus

Antimicrobial activities against oral bacteria and growth inhibition against Actinomyces viscosus using Lentinus edodes various extracts

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