Antihypertensive activity of 7-azaindole-3-acetamidoxime and indole-1-acetamidoxime

Synthesis, crystal structure, molecular docking and antimicrobial evaluation of new pyrrolo[3,2-c]pyridine derivatives

“…Compounds were purified by column chromatography on silica gel 230-400 using petether/ethyl acetate or dichloromethane/methanol solvent mixtures as eluent. All the compounds were characterized by 1 H NMR, 13 C NMR, LCMS and elemental analysis. Melting points of the samples were determined in open capillary tubes using Buchi Melting point B-540 apparatus and are uncorrected.…”

“…Crystal data for 6a, C 13 reflections measured (9.244 6 2H 6 145.144), 2404 unique (R int = 0.0381) which were used in all calculations. The final R 1 was 0.0420 (I > 2r(I)) and wR 2 was 0.1254 (all data) ( Table 1).…”

“…Other examples include the synthetic pyrrolopyridine derivative diazarebeccamycin 2 is a potent anticancer agent [2], pyrrolo [2,3-c]pyridine 3 which has demonstrated activity as an inhibitor of HIV-1 attachment to CD4 + T cells [3] and pyrrolo [2,3-b]pyridine 4 is a potent p38 kinase inhibitor [4]. Pyrrolopyridines also posses significant biological applications such as antimicrobial [5][6][7][8][9], analgesic [10], antimalarial [11], antiproliferative [12], antihypertensive [13], cannabinoid activity [14,15] and Factor VIIa inhibitors [16]. As a result of our considerable interest in the synthesis of pyridine-containing compounds and their antimicrobial activity [17], we initiated a programme directed towards the synthesis of new pyrrolopyridine compounds.…”