Antihypertensive and antidiabetic activities of Erythrina senegalensis DC (Fabaceae) stem bark aqueous extract on diabetic hypertensive rats

Bilanda, Danielle Claude; Bidingha, Ronald à Goufani; Dzeufiet, Paul Désiré Djomeni; Fouda, Yannick Bekono; Ngapout, Rodrigue Fifen; Tcheutchoua, Yannick Carlos; Owona, Pascal Emmanuel; Wouamba, Steven Collins Njonte; Tatchou, Lucie Tanfack; Dimo, Théophile; Kamtchouing, Pièrre

doi:10.1016/j.jep.2019.112200

Cited by 28 publications

(22 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The oxidative stress markers were changed in the rats as a result of the onset of diabetes. GSH concentration, SOD, GST, and Px activities were reduced with a concomitant increase in MDA concentration, reflecting impaired antioxidant defence with a subsequent increase in oxidative stress [ 57 , 58 ]. However, TCA treatment improved the impaired antioxidant system while reducing oxidative stress (Figures 1 – 5 ).…”

Section: Discussionmentioning

confidence: 99%

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

Iheagwam

Batiha

Ogunlana

et al. 2021

International Journal of Inflammation

View full text Add to dashboard Cite

This study aims at evaluating the ameliorative role of Terminalia catappa aqueous leaf extract (TCA) on hyperglycaemia-induced oxidative stress and inflammation in a high-fat, low dose streptozotocin-induced type 2 diabetic rat model. Experimental rats were treated orally with 400 and 800 mg/kg bw TCA daily for four weeks. Antioxidant enzyme activities, plasma glucose concentration, protein concentration, oxidative stress, and inflammation biomarkers were assayed using standard methods. Hepatic relative expressions of tumour necrosis factor-alpha (TNF-α), interleukin-six (IL-6), and nuclear factor-erythroid 2 related factor 2 (Nrf-2) were also assessed. Molecular docking and prediction of major TCA phytoconstituents’ biological activity related to T2DM-induced oxidative stress were evaluated in silico. Induction of diabetes significantly ( p < 0.05 ) reduced superoxide dismutase, glutathione-S-transferase, and peroxidase activities. Glutathione and protein stores were significantly ( p < 0.05 ) depleted, while glucose, MDA, interleukin-six (IL-6), and tumour necrosis factor-α (TNF-α) concentrations were significantly ( p < 0.05 ) increased. A significant ( p < 0.05 ) upregulation of hepatic TNF-α and IL-6 expression and downregulation ( p < 0.05 ) of Nrf-2 expression were observed during diabetes onset. TCA treatment significantly ( p < 0.05 ) modulated systemic diabetic-induced oxidative stress and inflammation, mRNA expression dysregulation, and dysregulated macromolecule metabolism. However, only 800 mg/kg TCA treatment significantly ( p < 0.05 ) downregulated hepatic TNF-α expression. 9-Oxabicyclo[3.3.1]nonane-2,6-diol and 1,2,3-Benzenetriol bound comparably to glibenclamide in Nrf-2, IL-6, and TNF-α binding pockets. They were predicted to be GST A and M substrate, JAK2 expression, ribulose-phosphate 3-epimerase, NADPH peroxidase, and glucose oxidase inhibitors. These results suggest that TCA ameliorates hyperglycaemia-induced oxidative stress and inflammation by activating Nrf-2 gene.

show abstract

Section: Discussionmentioning

confidence: 99%

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

Iheagwam

Batiha

Ogunlana

et al. 2021

International Journal of Inflammation

View full text Add to dashboard Cite

show abstract

“…In addition, scientific consistency of all medicinal uses is supported by numerous studies highlighting the anticancer [10], antihypertensive, antidiabetic [11], antiinflammatory, antiplasmodial [12], antibacterial [13,14], anti-HIV [15], antiparasitic [16], antioxidant [17,18] and enzyme inhibitory [19,20] properties of extracts and/or secondary metabolites isolated from this plant. Similar broad range of pharmacological activities has been observed with respect to the Mimosa genus [21,22].…”

Section: Introductionmentioning

confidence: 92%

In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts

et al. 2022

View full text Add to dashboard Cite

Although Erythrina senegalensis is a plant widely used in traditional medicine in sub-Saharan Africa, its biological properties have been poorly investigated to date. We first characterized by conventional reactions the composition of several stem bark extracts and evaluated in acellular and cellular assays their pro- or antioxidant properties supported by their high phenolic and flavonoid content, particularly with the methanolic extract. The pro- or antioxidant effects observed did not correlate with their IC50 concentrations against five cancer cell lines determined by MTT assay. Indeed, the CH2Cl2 extract and its ethyl acetate (EtOAc) subfraction appeared more potent although they harbored lower pro- or antioxidant effects. Nevertheless, at equipotent concentration, both extracts induced ER- and mitochondria-derived vacuoles observed by fluorescent microscopy that further led to non-apoptotic cell death. LC coupled to high resolution MS investigations have been performed to identify chemical compounds of the extracts. These investigations highlighted the presence of compounds formerly isolated from E. senegalensis including senegalensein that could be retrieved only in the EtOAc subfraction but also thirteen other compounds, such as 16:3-Glc-stigmasterol and hexadecanoic acid, whose anticancer properties have been previously reported. Nineteen other compounds remain to be identified. In conclusion, E. senegalensis appeared rich in compounds with antioxidant and anticancer properties, supporting its use in traditional practice and its status as a species of interest for further investigations in anticancer drug research.

show abstract

“…Anti malarial, analgesic, anti-inflammatory, antibacterial actions [49]; gastrointestinal disorders, fever, jaundice, eye infections, body pain, liver disorders, diuretic [50]; antihypertensive, hypoglycemic, hypolipidemic, cardiomodulator and antioxidant properties [51].…”

Section: Erythrina Senegalensislmentioning

confidence: 99%

Ethnobotanical Study of Medicinal Plants used as Anti-Obesity Remedies in Foumban and Dschang Cities (West-Cameroon)

Epoh¹,

Dongmo²,

Tchouanguep³

et al. 2020

EJMP

View full text Add to dashboard Cite

Aim: Obesity is a public health problem on a global and national scale. It is associated with high blood pressure, type II diabetes and certain metabolic complications. In Cameroon, obesity is observed in both rural and urban population where the people are still very attached to traditional values to solve their health problems. The present study was aimed at determining antiobesity medicinal plants used by the traditional healers in the Foumban and Dschang Municipalities. Methodology: An ethnobotanical study of medicinal plants used against obesity was conducted in 2 localities, Foumban and Dschang, of the western region of Cameroon. The questionnaire was submitted and the information was collected via oral interviews with traditional healers and the people of the localities who benefited from anti-obesity treatments based on medicinal plants. Results: Twenty five medicinal plants belonging to 16 families and used in the management of obesity were identified. Leaves and bark are the most used plant parts; they are followed by fruits (seeds) and Roots. Most herbal remedies are prepared as decoction in Foumban (30%) and Dschang (62%) respectively. The most common plant used by these people was Solanum indicum (49.27%, Foumban) and Tetrapleura tetraptera (40%, Dschang). Conclusion: Relatively to the management of obesity with medicinal plants, the population of these localities presented interesting knowledge. However, there is still a need for further pharmacological and phytochemical investigations of the above common and most used ones.

show abstract

Antihypertensive and antidiabetic activities of Erythrina senegalensis DC (Fabaceae) stem bark aqueous extract on diabetic hypertensive rats

Cited by 28 publications

References 24 publications

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene

In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts

Ethnobotanical Study of Medicinal Plants used as Anti-Obesity Remedies in Foumban and Dschang Cities (West-Cameroon)

Contact Info

Product

Resources

About