Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inNG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats

Mali, Vishal; Bodhankar, Subhash L.

doi:10.3109/13880209.2012.684064

Cited by 38 publications

(27 citation statements)

References 58 publications

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“…108 Fruit powder significantly reduced systolic and diastolic blood pressures in N(G)-nitro-Larginine methyl ester (L-NAME)-induced hypertensive rats. 109…”

Section: Resultsmentioning

confidence: 99%

Śākadravya (Vegetables) as Pathya in Metabolic Disorders–A Review from Classical Texts of Āyurveda with Current Evidences

Borkar¹

2018

Journal of Drug Research in Ayurvedic Sciences

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Aim:To review the vegetables mentioned as pathya for metabolic diseases like prameha/madhumeha, hṛdroga, and sthaulya from 15 different classical texts and to analyze the available data critically with the help of reported research activities to establish their role in the prevention and management of metabolic disorders.Background: Metabolic syndrome is a multifactorial disorder, which can be prevented by changes in lifestyle and dietary habits. Among the preventive measures given for various disorders, the classical texts of Āyurveda describe all the vegetables along with their guṇa (properties), karma (action), and prayoga (indication) in different disease conditions under śākavarga. As diet is considered as the best preventive medicine, vegetables are indicated as pathya (wholesome diet) for metabolic diseases like prameha/madhumeha, hṛdroga, and sthoulya, and can be used in the prevention and management of metabolic disorders. Review results:It is observed that among 318 vegetables mentioned in compiled texts, 29 vegetables are indicated in prameha/madhumeha and 33 vegetables are indicated in hṛdroga. Majority of these vegetables are reported for their antidiabetic (18), anti-hyperlipidemia (14), cardio-protective (15), anti-hypertensive (7), and antiplatelet (5) activities. Conclusion:Vegetables mentioned under śākavarga in classical texts of Āyurveda can be effectively used as pathya in metabolic disorders.Clinical significance: On the basis of review results, further scientific studies can be planned clinically to evaluate the beneficial effects of these vegetables in clinical practice.

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“…108 Fruit powder significantly reduced systolic and diastolic blood pressures in N(G)-nitro-Larginine methyl ester (L-NAME)-induced hypertensive rats. 109…”

Section: Resultsmentioning

confidence: 99%

Śākadravya (Vegetables) as Pathya in Metabolic Disorders–A Review from Classical Texts of Āyurveda with Current Evidences

Borkar¹

2018

Journal of Drug Research in Ayurvedic Sciences

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“…The hypertensive rat model generated by L-NAME has been widely employed to evaluate the effects of different antihypertensive molecules [ 45 , 46 ]. In the present study, we aimed to assess whether ethanolic extract obtained of chia seeds (EESH) has antihypertensive activities.…”

Section: Discussionmentioning

confidence: 99%

“…To induce HT, 12 8-week-old male Wistar rats, weighing 250 g, were treated with N-nitro-L-arginine methyl ester (L-NAME; 40 mg/kg/day) [ 45 , 46 ]. Four rats receiving distilled water comprised the control group (without HT).…”

Section: Methodsmentioning

confidence: 99%

Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways

et al. 2020

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Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias. Angiotensin-converting enzyme inhibitors (ACEIs) blocked the renin-angiotensin-aldosterone cascade diminishing the production of angiotensin II and the level of bradykinin, produced by the kallikrein-kinin system. Although ACEIs are effective therapeutics in regulating HT, they present several side-effects that can be due to their mechanism of action (as hypotension, cough, dizziness, light-headedness or hyperkalemia) to specific drug molecular structure (skin rash, neutropenia and tasting disorders) or due to associated pathologies in the patients (it has been considered a possible nephrotoxic effect when ACEIs are administered in combination with angiotensin receptor blockers, in patients that present comorbidities as diabetes, acute kidney injury or chronic kidney disease). Therefore, it is necessary the searching for new products with ACEI activity that do not produce side effects. Interestingly, species of the plant genus Salvia have been found to possess hypotensive effects. In the present study, we analyzed the effects of the ethanolic extract of Salvia hispanica L. seeds (EESH) on the expression of genes involved in pathways regulating HT. Administration of EESH to hypertensive rats inhibited the angiotensin-converting enzyme (ACE) activity along with a decrease in Ace and elevation of Agtr1a and Nos3 gene expression, as compared to that in healthy rats. Moreover, these results were similar to those observed with captopril, an antihypertensive drug used as a control. No significant change in the expression of Bdkrb2 gene was observed in the different groups of rats. To conclude, our results demonstrate that EESH regulates blood pressure (BP) in hypertensive rats through transcriptionally regulating the expression of genes that participate in different pathways involving ACE.

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“…Many studies have reported a reduction in blood pressure following the consumption of favonoid-rich products. In vitro studies have reported that favonoids such as genistein, quercetin, and (-)epicatechin regulated (directly or indirectly) NO production in isolated vessels or cultured endothelial cells [8,24,27]. However, most of them do not establish a clear dose-structure-activity relationship.…”

Section: Disicussionmentioning

confidence: 99%

Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats

Paredes¹,

Romecín²,

Atucha³

et al. 2018

Preprint

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1) Background: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. 2) Methods: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. 3) Results: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. 4) Conclusions: the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.

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Antihypertensive and cardioprotective effects of theLagenaria sicerariafruit inN^G-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats

Cited by 38 publications

References 58 publications

Śākadravya (Vegetables) as Pathya in Metabolic Disorders–A Review from Classical Texts of Āyurveda with Current Evidences

Śākadravya (Vegetables) as Pathya in Metabolic Disorders–A Review from Classical Texts of Āyurveda with Current Evidences

Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways

Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats

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