Antihypertensive and free radical scavenging properties of enzymatic rapeseed protein hydrolysates

He, Rong; Alashi, Adeola M.; Malomo, Sunday A.; Girgih, Abraham T.; Chao, Dongfang; Ju, Xingrong; Aluko, Rotimi E.

doi:10.1016/j.foodchem.2013.02.087

Cited by 133 publications

(133 citation statements)

References 35 publications

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“…Hypertension is an increasing health problem which affects one third of the worldwide adult population, both men and women, especially in developed countries, and presents the most common type of cardiovascular disease Hong et al, 2008;Shahidi and Zhong, 2008;Hernández-Ledesma et al, 2011;He et al, 2013). High blood pressure is predominant factor which contibutes to cardiovascular diseases including myocardial infarction, heart failure, coronary heart disease, peripheral artery disease, stroke kidney failure, blindness, end-stage diabetes and even dementia (Hong et al, 2008;Ahhmed and Muguruma, 2010;Hernández-Ledesma et al, 2011;Ryan et al, 2011;Sharp et al, 2011;Rutherfurd-Markwick, 2012;He et al, 2013).…”

Section: Antihypertensive Propertiesmentioning

confidence: 99%

“…High blood pressure is predominant factor which contibutes to cardiovascular diseases including myocardial infarction, heart failure, coronary heart disease, peripheral artery disease, stroke kidney failure, blindness, end-stage diabetes and even dementia (Hong et al, 2008;Ahhmed and Muguruma, 2010;Hernández-Ledesma et al, 2011;Ryan et al, 2011;Sharp et al, 2011;Rutherfurd-Markwick, 2012;He et al, 2013). It is one of the main causes of the premature death, and WHO estimates that by 2020, heart disease and stroke will become the leading causes of death and disability worldwide (Erdmann et al, 2008;Onuh et al, 2013).…”

Section: Antihypertensive Propertiesmentioning

confidence: 99%

“…Synthetic substances directly block action of ACE (angiotensin-converting enzyme) responsible for converting angiotensin-I into angiotensin-II, major product of the renin-angiotensin system which presents a powerful vasoconstrictor. ACE hydrolyze bradykinin, a potent vasodilator, also induces the release of aldosterone in the adrenal cortex, which results in increasing of sodium concentration and blood pressure (Wu et al, 2008;Ahhmed and Muguruma, 2010;Hernández-Ledesma et al, 2011;Cam and de Mejia, 2012;Escudero et al, 2012;He et al, 2013;Udenigwe and Ashton, 2013). Mechanism of action of ACE inhibitory peptides is based on competing with ACE and preventing the production of angiotensin-II, causing relaxation of the arterial walls and reduction of fl uid volume, in which way these biactive peptides improve heart function and increase blood and oxygen fl ow to the heart, liver, and kidneys (Ahhmed and Muguruma, 2010;Ryan et al, 2011;He et al, 2013).…”

Section: Antihypertensive Propertiesmentioning

confidence: 99%

“…ACE hydrolyze bradykinin, a potent vasodilator, also induces the release of aldosterone in the adrenal cortex, which results in increasing of sodium concentration and blood pressure (Wu et al, 2008;Ahhmed and Muguruma, 2010;Hernández-Ledesma et al, 2011;Cam and de Mejia, 2012;Escudero et al, 2012;He et al, 2013;Udenigwe and Ashton, 2013). Mechanism of action of ACE inhibitory peptides is based on competing with ACE and preventing the production of angiotensin-II, causing relaxation of the arterial walls and reduction of fl uid volume, in which way these biactive peptides improve heart function and increase blood and oxygen fl ow to the heart, liver, and kidneys (Ahhmed and Muguruma, 2010;Ryan et al, 2011;He et al, 2013). ACE inhibitory peptides may bind to the active site of the ACE enzyme, or to an inhibitor site located on the ACE enzyme, and in this way change the protein confi rmation and prevent the angiotensin-I from binding to the enzyme active site (Wijesekara and Kim, 2010;Ryan et al, 2011).…”

Section: Antihypertensive Propertiesmentioning

confidence: 99%

See 3 more Smart Citations

Bioactive peptides from meat and their influence on human health

Baltić¹,

Bošković²,

Ivanović³

et al. 2014

Tehnologija mesa

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Section: Antihypertensive Propertiesmentioning

confidence: 99%

Section: Antihypertensive Propertiesmentioning

confidence: 99%

Section: Antihypertensive Propertiesmentioning

confidence: 99%

Section: Antihypertensive Propertiesmentioning

confidence: 99%

See 2 more Smart Citations

Bioactive peptides from meat and their influence on human health

Baltić¹,

Bošković²,

Ivanović³

et al. 2014

Tehnologija mesa

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“…29 Rapeseed protein isolate (RPI) digested with proteinase, thermolysin, flavourzyme and pepsin produced rapeseed protein hydrolyzates which can be separated into different anti hypertensive peptides. 30 At large scale the serine type protease Alcalase is most widely used endo-protease in digests of various plant proteins such as rapeseed, canola, sunflower seed protein, soy protein legumes, rice as well as mung and chick beans showing high potency for ACE inhibition. Antihypertensive peptides produced by fermentation: Many industrially utilized dairy starter cultures are highly proteolytic in nature and can be used for production of antihypertensive peptides by fermentation of dairy products.…”

mentioning

confidence: 99%

Antihypertensive Peptides Derived From Food Sources

Balgir¹

2016

MOJFPT

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Abbreviations: ACE, angiotensin-converting enzyme; RAS, renin-angiotensin system; ENOS, endothelial nitric oxide synthase; NO, nitric oxide; LAB, lactic acid bacteria; SHRs, spontaneously hypertensive rats; ECE, endothelin-1 and endothelin converting enzyme; ET, endothelin; MRW, met-Arg-Trp; FPI, flaxseed protein isolate; RPI, rapeseed protein isolate; BSFP, black-bone silky fowl muscle peptides; DBP, diastolic blood pressure; IER, inhibitory efficiency ratio; AHPM, antihypertensive peptide multimer IntroductionHigh blood pressure or hypertension is a serious medical condition, caused due to a high flow of blood through the blood vessels with a force greater than normal. It strains the heart muscles and damages the blood vessels leading to stroke and finally death, if untreated. 1Untreated hypertension is usually associated with a progressive rise in blood pressure.2 It is the most common cause of morbidity and chronic metabolic disorders in the world. It is estimated to affect billions of individuals worldwide affecting 25% of most adult populations. 3,4 Hypertension as been called a silent killer as it has been implicated as the underlying cause for development of haemorrhagic stroke, cognitive decline, myocardial infarction, heart failure, chronic kidney disease and premature death. 5Hypertension may be classified as essential or secondary. Essential hypertension is the term for high blood pressure with no known etiological cause. Essential hypertension is caused by many factors:ii. lifestyle and environmental influences, andiii. disturbances in vascular structure and neuro-humoral control mechanisms. 5It accounts for about 95% of cases. Secondary hypertension is the term for high blood pressure associated with a known aetiology such as kidney disease, tumours or birth control pills. At present, it is widely accepted that approximately 30-50% of cases of hypertension can arise from genetic susceptibility. Monogenic forms of hypertension provide a unique opportunity to study the effects of single gene and identifying pathways and mechanisms leading to blood pressure elevation. 6 A number of pathways have been involved in the causation of hypertension amongst humans. Prominent among them are the pathways for fluid and electrolyte balance; the reninangiotensin system (RAS), the kinin-kallikrein system, the neutral endopeptidase system and the endothelin-converting enzyme system. Thus in clinical practice, vasodilators, diuretics, calcium channel blockers, angiotensin II receptor blockers and ACE inhibitors have been normally used as drugs.7 Most drugs target one or the other pathways to control hypertension. The response to drugs is varied and thus in non-responders may lead to metabolic disorders like diabetes, vascular blockage etc.Due to a high prevalence of hypertension among human population, a multipronged approach including changes in life-style, dietary approaches and pharmacological treatments is the need of the hour. Peptides of food origin have been reported to play an important prophylactic role in t...

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Effects of Succinylation on the Physicochemical Properties and Structural Characteristics of Edible Rapeseed Protein Isolate Films

Dai

et al. 2019

J Americ Oil Chem Soc

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This study described the manufacture and characterization of different levels of succinic anhydride (0-15%, w/w) on rapeseed protein isolate (RPI) films. Mechanical, barrier, optical, surface, microstructure, and thermal properties were investigated. Results showed that 5% succinylated rapeseed protein isolate (SRPI) film revealed the overall optimal properties. The mechanical and barrier properties of 5% SRPI film were enhanced significantly compared to the RPI film. The water vapor permeability values of RPI and 5% SRPI films were 0.77 and 0.32 g mm/[hour m 2 kPa], respectively. Succinylation improved the color of RPI. The contact angle of 5% SRPI film was 108.68 and was the most hydrophobic combination. Moreover, scanning electron microscopy images revealed that 5% SRPI showed a dense, homogenous, and smooth microstructure. Thermogravimetric analysis results verified a low level of succinylation strengthened the thermal resistance of SRPI films. The content of β-sheet was almost half of all secondary structures after succinylation, which was supported by analyses of Fourier transform infrared spectroscopy. Results demonstrated that succinylation could be employed to improve the properties of rapeseed protein and SRPI films have great potential to be used as edible films.

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Antihypertensive and free radical scavenging properties of enzymatic rapeseed protein hydrolysates

Cited by 133 publications

References 35 publications

Bioactive peptides from meat and their influence on human health

Bioactive peptides from meat and their influence on human health

Antihypertensive Peptides Derived From Food Sources

Effects of Succinylation on the Physicochemical Properties and Structural Characteristics of Edible Rapeseed Protein Isolate Films

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