Antihypertensive Drug Withdrawal Syndrome

Cummings, Doyle M.; Vlasses, Peter H.

doi:10.1177/106002808201601102

Cited by 16 publications

(6 citation statements)

References 52 publications

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“…(OVERSTREET and YAMAMURA 1979;PARKER and ATKINSON 1982;CUMMINGS and VLASSES 1982 ). It has been suggested that these processes may be involved in the development of, on the one hand, tolerance -after exposure to agonists-and on the other hand rebound or withdrawal phenomena after receptor blockade.…”

Section: Iatrogenic Receptor Imbalancementioning

confidence: 99%

Receptors: the materialization of a concept

Ariëns

1983

Pharmaceutisch Weekblad Scientific Edition

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The evolution of the receptor concept over the years, culminating in the materialization thereof is outlined step by step. Attention is paid to molecular pharmacology, affinity and intrinsic activity, partial agonists and partial antagonists, receptor differentiation, receptor kinetics, receptor dynamics, receptor-effector coupling and receptor reserve, localization, quantification and isolation of receptors. Receptor pathology includes 'inborn errors of receptor function', involvement of receptors in autoimmune diseases and in malignant diseases. Finally iatrogenic receptor imbalances are discussed.

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Section: Iatrogenic Receptor Imbalancementioning

confidence: 99%

Receptors: the materialization of a concept

Ariëns

1983

Pharmaceutisch Weekblad Scientific Edition

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“…In patients concomitantly receiving β-adrenergic blockers and clonidine, the β-adrenergic blocker should be withdrawn at least five half-lifes prior to introduction of clonidine, otherwise the initial unopposed α-adrenergic stimulation may result in hypertensive crisis [109,110].…”

Section: Clonidinementioning

confidence: 99%

“…Clonidine [109,110] Unopposed α-adrenergic stimulation upon β-adrenergic blocker withdrawal Hypertensive crisis…”

Section: Renal Eliminationmentioning

confidence: 99%

Antihypertensive therapy: special focus on drug interactions

Maas

Böger²

2003

Expert Opinion on Drug Safety

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Today, the lifetime risk of patients aged 55-65 years to receive antihypertensive drugs approaches 60%. Yet, recent trials suggest that hypertension is not adequately controlled in the majority of patients. The prevalence of hypertension increases with advancing age, as does the prevalence of comorbid conditions and the total number of medications taken. Multi-drug therapy, advancing age and comorbid conditions are also key risk factors for adverse drug reactions and drug interactions. In this review, the authors evaluate the most frequently used antihypertensive drugs (diuretics, beta-adrenergic blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers, angiotensin II receptor Type 1 blockers and alpha-adrenergic blockers) with special reference to pharmacodynamic and pharmacokinetic drug interactions. As the spectrum of drugs prescribed is constantly changing, safety yesterday does not imply safety today and safety today does not imply safety tomorrow. Furthermore, therapeutic efficacy should not be neglected over concerns regarding drug interactions. Many patients are at risk of clinically relevant drug interactions involving antihypertensive drugs but, presently, even more patients may be at risk of suffering from the consequences of their inadequately treated hypertension. In this respect, the authors discuss controversial viewpoints on the overall clinical relevance of drug interactions occurring at the level of cytochrome P450 metabolism.

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“…15 Withdrawal from clonidine is associated with rebound hypertension. 16 This has not yet been studied with dexmedetomidine. We now know a lot about the safety of individual sedative agents and a little about their safe use in the critically ill. We need to know a lot more about dexmedetomidine before we can use it with con®dence.…”

mentioning

confidence: 99%

Editorial I

Shelly¹

2001

British Journal of Anaesthesia

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Antihypertensive Drug Withdrawal Syndrome

Cited by 16 publications

References 52 publications

Receptors: the materialization of a concept

Receptors: the materialization of a concept

Antihypertensive therapy: special focus on drug interactions

Editorial I

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