Antihypertensive effect of novel angiotensin I converting enzyme inhibitory peptide from chum salmon (Oncorhynchus keta) skin in spontaneously hypertensive rats

Characterization and identification of angiotensin I-converting enzyme (ACE) inhibitory peptides derived from tilapia using Virgibacillus halodenitrificans SK1-3-7 proteinases

“…Until now, several commercial proteinases such as Alcalase (Charoenphun et al, 2013;Chen et al, 2012;Intarasirisawat, Benjakul, Wu, & Visessanguan, 2013), pepsin (Sheih, Fang, & Wu, 2009;Wang et al, 2008), trypsin (Asoodeh et al, 2012;Lee, Jeon, & Byun, 2014), thermolysin (Ghassem, Arihara, Babji, Said, & Ibrahim, 2011), and Flavourzyme (Khantaphant et al, 2011) have been used to produce protein hydrolysates with ACE inhibitory peptides. However, the use of proteinases from novel sources in protein hydrolysate production has not been widely studied.…”

Potato protein hydrolysate attenuates high fat diet-induced cardiac apoptosis through SIRT1/ PGC-1á/Akt signalling

“…Bioactive peptides with various physiological functions have been identified and their applications are extensively studied (Chiang et al, 2014;Lee, Jeon, & Byun, 2014;Ngo, Kang, Jung, Byun, & Kim, 2014;Shi, Kovacs-Nolan, Jiang, Tsao, & Mine, 2014). In animals as well as in human, gastrointestinal digestion of proteins to simpler peptides enhances the actions of parent proteins (Korhonen & Pihlanto, 2003).…”

Production and identification of angiotensin I-converting enzyme (ACE) inhibitory peptides from Mediterranean fish discards

“…A number of previous studies have described the ACEinhibitory activity of marine protein hydrolysates produced from different species such as yellowfin sole (Limanda aspera) (Jung et al, 2006), pacific hake (Merluccius productus) (Cinq-Mars & Li-Chan, 2007), sardinelle (Sardinella aurita) (Bougatef et al, 2008), cuttlefish (Sepia officinalis) (Balti, Nedjar-Arroume, Yaba-Adjé, Guillochon, & Nasri, 2010), loach (Misgurnus anguillicaudatus) (Li, Zhou, Huang, Sun, & Zeng, 2012) and chum salmon (Oncorhynchus keta) (Lee, Jeon, & Byun, 2014). However, to the best of the authors' knowledge, apart from sardine (S. pilchardus) which has been extensively studied (Bordenave et al, 2002;García-Moreno, Pérez-Gálvez, Espejo-Carpio, et al, 2013;Matsui et al, 1993), there is no previous work on the production of fish protein hydrolysates with ACE-inhibitory activity from the chosen discarded species in the Alboran Sea.…”