Antihypertensive Effect of Sesamin. IV. Inhibition of Vascular Superoxide Production by Sesamin.

Abstract

We previously demonstrated the preventive effect of sesamin, a lignan from sesame oil, on the development of several experimental models of hypertension. In the present study, we explored the mechanisms underlying the antihypertensive effect of sesamin using the deoxycorticosterone acetate (DOCA)-salt rat hypertensive model. After a 5-week treatment period, aortic superoxide (O 2 ؊ ) production was measured in the lucigenin chemiluminescence assay. Chemiluminescence signals significantly decreased in sesamin-containing diet-fed DOCA-salt hypertensive rats compared with those in the normal diet-fed DOCA-salt rats, although the signals in sham-operated control animals were not affected by the sesamin feeding. In addition, there was a positive correlation between systolic blood pressure and aortic O 2 ؊ production. These findings suggest that sesamin feeding inhibits enhanced vascular O 2 ؊ production in DOCA-salt hypertensive rats and that the antioxidative action of sesamin may contribute to its antihypertensive activity. Key words sesamin; deoxycorticosterone acetate (DOCA)-salt hypertension; superoxideWe have demonstrated the antihypertensive effect of sesamin, a lignan from sesame oil, in several types of experimental hypertensive models.1-3) The most efficient activity was observed in the deoxycorticosterone acetate (DOCA)-salt hypertensive rat model. When sesamin-containing diets were fed to the animals, the development of hypertension and cardiovascular hypertrophy were markedly attenuated.1) Most recently, we found that dietary sesamin efficiently improved the diminished endothelium-dependent vasorelaxation in DOCA-salt hypertensive animals. 4) In salt-loaded strokeprone spontaneously hypertensive rats (SHR-SP), sesamin feeding also effectively reduced histologic renal damage such as thickening of the tunica intima and fibrinoid degeneration of the arterial wall, in addition to inhibiting the development of hypertension and cardiovascular hypertrophy. 3)Several studies have been conducted on the biological activities of sesamin and the results have indicated that sesamin inhibits lipid metabolism, such as desaturation in polyunsaturated fatty acid biosynthesis 5) and cholesterol absorption. 6)Furthermore, sesamin is known to exert protective effects against liver damage caused by alcohol or carbon tetrachloride, 7) and against 7,12-dimethylbenz[a]anthracene-induced rat mammary carcinogenesis.8) These effects of sesamin may be due, at least in part, to immunopotentiation and antioxidative activity. production is increased in several animal models of hypertension and that antioxidants, such as vitamin C and vitamin E, attenuate the elevation of blood pressure and the impairment of vascular reactivity in hypertensive animals, 9) although antihypertensive therapy did not always prevent the increased oxidative stress. 10) In the present study, we investigated the possible mechanisms of the antihypertensive effect of sesamin in DOCA-salt hypertensive rats. We hypothesized that sesamin feeding inhibits enhanced v...

Sesame oil enhances endogenous antioxidants in ischemic myocardium of rat

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Sesame Oil as a Protective Agent Against Doxorubicin Induced Cardio Toxicity in Rat

“…SO attenuates oxidative stress and multiple organ failure triggered by endotoxin lipopolysaccharide in rats [8] . Sesamin and sesaminol are the major phenolic constituents of SO which have been reported to possess a broad spectrum of pharmacological effects including antimutagenic [9] , antioxidant [10,11,12] ,antihypertensive [11] ,antiinflammatory [12] and antithrombotic [13] . This investigation was set to evaluate the protective effects of SO against DOX-induced cardiotoxicity in male rats and to study the mechanisms underlying these effects.…”

Development of Vegetable Based Milk from Decorticated Sesame (Sesamum Indicum)

“…Recently, much attention has been directed toward exploring the utilization of oilseeds in general [10] and sesame seed in special [11] for new food uses on the basis of their functional properties. Decorticated sesame seed can supply us with nutritious [3,6] functional [14] and healthy meals [8,12,13,18] with relatively low cost. The production of sesame-based dairy products can overcome the problems that limit consumption of soybased dairy products and other vegetable milk such as presence of anti-nutritional factors, Beany and astringent flavor low solids yield , Low dispersion stability flatulence factors [4,7,15] .…”