Antihypertensive Effect of the lyophilized Aqueous Extract of Lannea microcarpa in L-NAME-Induced Hypertensive Wistar Rats

Acute Oral Toxicity and Vasorelaxant Effects of Hydroethanolic Extract from <i>Lannea microcarpa</i> Engl. & K. Krause (Anacardiaceae) Trunk Barks in Mice Aortas: Possible Involvement of Intracellular Ca<sup> 2+</sup> Mobilization

“…Burkina Faso offers a great botanical treasure trove, given its geographical and climatic diversity, and is a major source of potentially therapeutic plants for the treatment of hypertension [12] [13]. Among the multitude of medicinal plants, traditional remedies prepared from the bark, roots, leaves and fruit of Lannea microcarpa Engl K. Krause (Anacardiaceae) are used to treat a wide range of conditions, including high blood pressure [6] [12] [14]. From a pharmacological point of view, Lannea microcarpa trunk barks extract has antioxidant activity and can reduce the harmful effects of oxidative stress on cells [6] [15].…”

“…The extracts also have anti-inflammatory properties [16] and induce vascular relaxation via inhibition of phosphodiesterases and intracellular calcium influx [6] [17]. They also have antihypertensive properties by counteracting the hypertensive effects of Ang II and L-NAME [6] [14]. However, depending on the polarity of the extraction solvent, the biological properties of plant extracts vary.…”