2020
DOI: 10.1016/j.biopha.2020.110240
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Antihypertensive effects of allicin on spontaneously hypertensive rats via vasorelaxation and hydrogen sulfide mechanisms

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Cited by 44 publications
(26 citation statements)
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“…As a sulfur compound, allicin has also been suggested to exert cardiovascular effects via the production of H 2 S in vivo ( Wang et al, 2010 ). We previously demonstrated that allicin reduced blood pressure by promoting vasodilation in spontaneously hypertensive rats by inducing H 2 S production ( Cui et al, 2020 ), a finding that was consistent with the literature. The present study aimed to evaluate the beneficial effects of allicin in a rat model of AMI and to elucidate the mechanisms related to H 2 S production.…”
Section: Introductionsupporting
confidence: 90%
“…As a sulfur compound, allicin has also been suggested to exert cardiovascular effects via the production of H 2 S in vivo ( Wang et al, 2010 ). We previously demonstrated that allicin reduced blood pressure by promoting vasodilation in spontaneously hypertensive rats by inducing H 2 S production ( Cui et al, 2020 ), a finding that was consistent with the literature. The present study aimed to evaluate the beneficial effects of allicin in a rat model of AMI and to elucidate the mechanisms related to H 2 S production.…”
Section: Introductionsupporting
confidence: 90%
“…Although inorganic sulfide salts (NaHS and Na 2 S) have been the most widely employed in biological and preclinical studies, none of them are unlikely to be a suitable clinical option for a number of reasons, including poor water solubility, fast and uncontrollable release, and unpleasant odor. Given that it is not trivial to synthesize a clinically suitable H 2 S donor in a short time, three types of potential H 2 S donors or drugs should be considered to block viral entry: (1) natural H 2 S donors (e.g., garlic and onions) [ 127 , 128 ] or dietary micronutrients (e.g., L-cysteine and taurine) [ 129 , 130 ], (2) H 2 S-donating derivatives of clinically used drugs that link various H 2 S donating groups to clinically used drugs (e.g., ATB-346 [ 131 ] and GIC-1001 [ 132 ] which has completed phase 2 clinical trial), and (3) several clinically used drugs that have been verified to increase H 2 S levels (e.g., α -lipoic acid, [ 133 ] sodium thiosulfate, [ 134 ] zofenoprilat, [ 135 ] and N-acetylcysteine [ 136 ]). Sodium thiosulfate has been proposed as an inhalation therapy for COVID-19, [ 137 ] and it was confirmed that the combined application of N-acetylcysteine improved the symptoms in COVID-19 patient.…”
Section: Discussionmentioning
confidence: 99%
“…However, it should be noted that the genetic deletion of CSE in mice does not impact steady-state mPAP in isolated perfused lung tissues [109], suggesting that endogenous H 2 S production by CSE is not involved in the regulation of basal mPAP, at least in mice. Derived organosulfur compounds from garlic, such as allicin, diallyl disulfide, and diallyl trisulfide, have for a long time been associated with H 2 S release under physiological conditions, triggering vascular relaxation in systemic vessels and decreasing blood pressure [58,112]. In pulmonary vascular beds, allicin-but not diallyl disulfide or trisulfide-dose-dependently relaxed rat PAs and reduced PA pressure in rat perfused lung tissues [113,114].…”
Section: The Role Of H 2 S In Pulmonary Artery Relaxationmentioning
confidence: 99%