Antihypertensive effects of Ocimum gratissimum extract: Angiotensin-converting enzyme inhibitor in vitro and in vivo investigation

Antihypertensive properties of aqueous extracts of vegetable leaf‐fortified bread after oral administration to spontaneously hypertensive rats

“…This is because 100 mg of the vegetable‐enriched breads produced about twice the SBP reduction reported for 50 mg chokeberry polyphenols. But the results obtained in this work show stronger SBP‐reducing effects of the vegetable‐fortified breads when compared to oral administration of 500 mg kg −1 SHR body weight of a vegetable leaf polyphenol extract that lowered SBP by only 8 mmHg (Shaw et al ., ). The vegetable‐fortified breads also have stronger SBP‐reducing effects than lingonberry juice, which produced 26 mmHg reductions after oral administration to SHR (Kivimaki et al ., ).…”

“…The DBP data are similar to previous works that have shown reductions in DBP of SHR after consumption of 50 mg chokeberry/kg body weight (Hellstrom et al ., ) and human volunteers who consumed 100 g of red beetroot‐enriched bread (Hobbs et al ., ). In contrast, oral administration of 500 mg vegetable leaf ( O. gratissimum ) polyphenol extract/kg SHR body weight did not produce any significant DBP reduction (Shaw et al ., ). The difference may be due to synergistic interactions between vegetable polyphenols and wheat polyphenols as discussed above.…”

“…For example, oral administration of lingonberry juice led to only 26 bpm decreases in heart rate (Kivimaki et al ., ), which is less than the results obtained in this work. In contrast, oral administration of 500 mg kg −1 body weight of O. gratissimum polyphenol extract produced no significant change in SHR heart rate (Shaw et al ., ). The potential release of bioactive peptides from bread proteins during yeast fermentation (Zhao et al ., ; Peñas et al ., ) in synergy with polyphenols may have contributed to the stronger heart rate‐reducing ability of the vegetable‐fortified breads.…”

“…Leafy vegetables are very rich sources of phytochemicals, especially polyphenols that can contribute to improved human health. This is because even though these phytochemicals have few or zero caloric values, they possess bioactive properties that have been linked to reduced risks of chronic diseases such as antioxidative, antihypertensive, anticancer, anti‐bactericidal and antiviral properties at low concentrations (Kayode & Kayode, ; Sreeramulu et al ., ; Gawlik‐Dziki et al ., ; Oboh et al ., ; Shaw et al ., ). Several works have focused on the extraction of polyphenols from leafy vegetables, including determination of the extract bioactive properties while others have studied the prevention of lipid peroxidation and other antioxidant properties (Kayode & Kayode, ; Segovia Gómez & Almajano Pablos, ; Shaw et al ., ).…”

Antioxidant, antihypertensive, and anticancer activities of the flavonoid fractions from green, oolong, and black tea infusion waste

“…Flavonoids could lower the blood pressure and inhibit the cancer cells growth due to their antioxidant activities (Lee et al, ; Sanchez‐Vioque et al, ). A lot of evidence indicated that flavonoid‐rich plants had antihypertensive activity (Perez‐Vizcaino & Duarte, ; Shaw, Wu, & Wang, ). Flavonoids had the ability of scavenging free radicals and preventing cancer that induced by oxidative stress (Shan, Wang, Russel, & Zhao, ).…”