Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents

Micucci, Matteo; Bolchi, Cristiano; Budriesi, Roberta; Cevenini, Monica; Maroni, Lorenzo; Capozza, S.; Chiarini, Alberto; Pallavicini, Marco; Angeletti, Andrea

doi:10.1016/j.phytochem.2019.112222

Cited by 13 publications

(6 citation statements)

References 225 publications

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“…For centuries, plants have represented the main tools for the treatment of human diseases. In the modern era, phytochemistry and pharmaceutical approaches were applied to investigate the mechanisms of action and the chemical composition of plants used in folk medicine [1,2]. The pharmaceutical value of plant extracts may be due to the synergy of the phytochemicals present in them, even if, rarely, the affection of specific functions may be ascribed to isolated molecules.…”

Section: Introductionmentioning

confidence: 99%

Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System

et al. 2020

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The petals of the saffron crocus (Crocus sativus L.) are considered a waste material in saffron production, but may be a sustainable source of natural biologically active substances of nutraceutical interest. The aim of this work was to study the cardiovascular effects of kaempferol and crocin extracted from saffron petals. The antiarrhythmic, inotropic, and chronotropic effects of saffron petal extract (SPE), kaempferol, and crocin were evaluated through in vitro biological assays. The antioxidant activity of kaempferol and crocin was investigated through the 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) assay using rat cardiomyoblast cell line H9c2. The MTT assay was applied to assess the effects of kaempferol and crocin on cell viability. SPE showed weak negative inotropic and chronotropic intrinsic activities but a significant intrinsic activity on smooth muscle with a potency on the ileum greater than on the aorta: EC50 = 0.66 mg/mL versus EC50 = 1.45 mg/mL. Kaempferol and crocin showed a selective negative inotropic activity. In addition, kaempferol decreased the contraction induced by KCl (80 mM) in guinea pig aortic and ileal strips, while crocin had no effect. Furthermore, following oxidative stress, both crocin and kaempferol decreased intracellular ROS formation and increased cell viability in a concentration-dependent manner. The results indicate that SPE, a by-product of saffron cultivation, may represent a good source of phytochemicals with a potential application in the prevention of cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%

Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System

et al. 2020

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“…Hypertension often has no symptoms even although it is one of the main risk factors for cardiovascular diseases in the world. These disorders are considered among the most severe worldwide public health threats since they are the leading cause of death [ 102 , 103 ]. Although the causes of hypertension are not well known, aging can be a risk factor because most people with hypertension are 60 years old or older, and it is a major risk factor for heart disorders, myocardial infarction [ 102 ].…”

Section: Impacts Of Polyphenols On Human Healthmentioning

confidence: 99%

“…Dietary adjustment is considered an important regulation method for the modulation of hypertension. Moreover, the principal efficient non-pharmacological interventions are represented by weight loss, intensification of physical activities, reduction of sodium, diet, and supplementation of potassium [ 103 ]. The antihypertensive activities of some phenolics are reported in Table 3 .…”

Section: Impacts Of Polyphenols On Human Healthmentioning

confidence: 99%

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Rathod

Abed

Punia³

et al. 2023

Plants

108

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Polyphenol has been used in treatment for some health disorders due to their diverse health promoting properties. These compounds can reduce the impacts of oxidation on the human body, prevent the organs and cell structure against deterioration and protect their functional integrity. The health promoting abilities are attributed to their high bioactivity imparting them high antioxidative, antihypertensive, immunomodulatory, antimicrobial, and antiviral activity, as well as anticancer properties. The application of polyphenols such as flavonoids, catechin, tannins, and phenolic acids in the food industry as bio-preservative substances for foods and beverages can exert a superb activity on the inhibition of oxidative stress via different types of mechanisms. In this review, the detailed classification of polyphenolic compunds and their important bioactivity with special focus on human health are addressed. Additionally, their ability to inhibit SARS-CoV-2 could be used as alternative therapy to treat COVID patients. Inclusions of polyphenolic compounds in various foods have demonstrated their ability to extend shelf life and they positive impacts on human health (antioxidative, antihypertensive, immunomodulatory, antimicrobial, anticancer). Additionally, their ability to inhibit the SARS-CoV-2 virus has been reported. Considering their natural occurrence and GRAS status they are highly recommended in food.

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“…[4][5][6] Moreover, AAI is a dual ETA/ETB receiver antagonist, suggesting immense potential in combating cardiovascular diseases, the number one cause of death and disability globally. 7,8 Nevertheless, AAI has been forbidden for clinical use by many countries due to its nephrotoxicity. 9,10 The chemical modication of AAI can be one promising way for full utilization of AAI by reducing its toxicity and increasing efficacy.…”

Section: Introductionmentioning

confidence: 99%

Efficient separation of aristolochic acid I from Caulis aristolochiae manshuriensis (Guan-mu-tong) with copper mediated magnetic molecularly imprinted polymer

Cao¹,

Shi²,

Lan³

et al. 2023

Anal. Methods

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Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents

Cited by 13 publications

References 225 publications

Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System

Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System

Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge

Efficient separation of aristolochic acid I from Caulis aristolochiae manshuriensis (Guan-mu-tong) with copper mediated magnetic molecularly imprinted polymer

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