Antihypertensive Potency of Wild Cosmos (Cosmos caudatus Kunth, Asteraceae) Leaf Extract

Amalia, Lia; Anggadired, Kusnandar; Sukrasno,; Fidrianny, Irda; Inggriani, Rini

doi:10.3923/jpt.2012.359.368

Cited by 15 publications

(6 citation statements)

References 20 publications

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“…After including other confounding factors such as age, education years, sex, household income and total polyphenol intake, the total ulam intake still showed positive correlation with all neuropsychological batteries in multiple linear regression. Ulam has been reported to be rich in antioxidants and polyphenols, and previous studies has proven it could exhibit medicinal properties such as anti-diabetic, anti-hypertensive, and neuroprotective (Bachok et al 2014, Amalia et al 2012, Ajaykumar et al 2012. Polyphenols and antioxidants are essential to protect against cognitive decline through attenuation of apoptosis and prevent oxidative stress (Sinclair & Guarente 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Some of the ulam has been used as medicinal plants or therapeutic agents as it contains high polyphenols and antioxidant content (Chan et al 2014;Kongkachuichai et al 2015;Reihani & Azhar 2012). Several animal studies have reported that ulam could exhibit several medicinal properties such as lowering the blood sugar, systolic pressure, blood cholesterol and inflammation states (Amalia et al 2012;Bachok et al 2014;Bora, Arora & Shri 2011;Perumal et al 2014). However, human studies are limited to prove that ulam is beneficial in exhibiting these properties.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Traditional Malaysian Vegetables (Ulam) Intake and Cognitive Status Among Middle-aged Adults from Low Cost Residential Areas

You

Shahar

Haron

et al. 2019

JSKM

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Ulam is fresh traditional Malaysian vegetables which normally consumed in raw form or after a short blanching process. It contains high antioxidants and polyphenols. However, there is limited study about the relationship between ulam consumption and cognitive status. Thus, a cross sectional study was conducted to determine the relation with cognitive function among 132 middle-aged Malays adults (45-59 years old), recruited by convenient sampling from low income residences in Klang Valley. Respondents were interviewed to obtain data on sociodemography, dietary intake and total ulam intake and also measured for anthropometric parameters at respective community centres. Cognitive status was measured using Digit Span (attention and working memory), Rey auditory verbal learning test (RAVLT) (verbal memory) and comprehensive trail making test (CTMT) (cognitive flexibility). The average ulam intake by the respondents was 15.1 ± 8.2g/day and the top five highest consumed ulam were petai (68.1%), pucuk paku (62.9%), ulam raja (56.8%), pegaga (54.6%) and kesum (44.7%).There was a significant correlation between ulam intake with Digit Span (r = 0.265, p = 0.006), total immediate recall of RAVLT (r = 0.427, p < 0.001) and CTMT (r = 0.257, p = 0.007). Analysis of multiple regression indicated that total ulam intake was a significant predictor for Digit Span (R 2 = 0.152, p < 0.05), RAVLT (R 2 = 0.335, p = 0.001) and CTMT (R 2 = 0.310, p < 0.001). In conclusion, this study showed that ulam has the potential to protect against cognitive decline, however, randomized control trials should be conducted to determine the efficacy of the ulam as neuroprotective agent.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between Traditional Malaysian Vegetables (Ulam) Intake and Cognitive Status Among Middle-aged Adults from Low Cost Residential Areas

You

Shahar

Haron

et al. 2019

JSKM

View full text Add to dashboard Cite

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“…In the adrenaline-treated cases (500 mg/ kg and 1,000 mg/kg), inhibition of adrenaline induced increase of heartbeat and stroke volume was reported. 23 Separately, the dichloromethane extract of C. Caudatus in vitro demonstrated a moderate suppression of the angiotensin-converting enzyme. 20 These results are indicative of the potential of C. caudatus as an antihypertensive agent.…”

Section: Antihypertensive Effectsmentioning

confidence: 98%

Tasty Herb that Heals: A Review of Cosmos caudatus (Ulam Raja) and its Potential Uses in Dentistry

Uzbek¹,

Shahidan²

2019

World Journal of Dentistry

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Aim: In recent years, there has been an increase in research on herbal derivatives with regards to their medicinal use. This review aims to summarize the scientific reports on one such herb, Cosmos caudatus . Our primary focus is to highlight its pharmacological properties and their potential applications in the field of dentistry. Background: The vascular plant biodiversity of Southeast Asia is second to that of South America, with many of these plants being used for their traditional medicinal benefits. One such herb that is popular in Malaysia is C. caudatus , locally referred to as ulam raja. It is an edible herb, commonly served in the form of a salad and is also used in traditional medicine practices to boost blood circulation, increase strength of bones, reduce fever, treat infections, and improve skin texture. Recent scientific studies have reported numerous pharmacological benefits of C. caudatus ranging from being an antioxidant agent to having bone-protective properties. These properties are attributed to a rich source of biochemical compounds found in the herb. A PubMed and Science Direct database search was conducted revealing 25 papers relevant to our review of C. caudatus , describing its traditional uses, pharmacological uses, botanical description, and phytochemical description. Review results: Published studies have reported that C. caudatus has potent antioxidant properties. It has shown both antibacterial and antifungal activities. Extracts of C. caudatus are capable of acting as an antihypertensive and antidiabetic agent, in both human and animal models. It also plays a role as a bone-protective and bone-proliferative agent. Conclusion: C. caudatus has the potential of being greatly beneficial in treating various dental diseases due to its pharmacological properties. Clinical significance: There is need for further research into this abundant natural resource in order to explore its potential uses in clinical dentistry.

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“…The plant extract from leaves possesses an excellent source of antioxidants and phenolic compounds as dominant compounds. Based on scientific evidence, the plant extract displays various pharmacological properties such as anti-bacterial, anti-inflammatory, bone-protective agent, and antidiabetic 1,[4][5][6] . Moreover, the extract of C. caudatus leaves has a strong antioxidant property and the content is higher compared to some tropical fruits, herbs, and vegetables 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic-Assisted Extraction (UAE) for Enhanced Recovery of Bioactive Phenolic Compounds From Cosmos Caudatus Leaves

Latiff

Ong

Abdullah

et al. 2021

Preprint

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Cosmos caudatus (C. caudatus) is one of the common medicinal plants and among the valuable plants that are high in bioactive compounds such as phenolics. In this study, an ultrasound-assisted extraction (UAE) method was used to optimise the extraction of bioactive compounds from C. caudatus leaves using response surface methodology (RSM) and employing a Box-Behnken experimental design (BBD). The extraction efficiency of UAE under the optimal extraction conditions was compared with the Soxhlet method. Also, an anti-microbial analysis against two human pathogenic bacteria; Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) was also evaluated. The effect of the extraction conditions was studied and optimised such as the solid-liquid ratio (10 to 30 g/ml), particle size (180 to 850 µm) and extraction time (20 to 30 min). Quercitrin and total phenolic content (TPC) were the selected response variables in this study. Based on the ANOVA analysis, the response surface model to predict the optimum yield of quercitrin and TPC was adequate with a high R-square value corresponding to 0.9930 and 0.9962. The optimal UAE conditions were 1:28 (g/mL), by using a particle size of 485 µm and an extraction time of 30 min, respectively. Remarkably, UAE reduced the extraction time and solvent volume, with the maximal recovery of bioactive compounds at a high antioxidant activity as compared with that of the Soxhlet method. The plant extract also exhibited potential microbial agents. Due to the above findings, UAE can be used to enrich quercitrin and total phenolic content from C. caudatus leaves. It also opens the possibility of plant extract to be used as an affordable component in many applications such as food formulations and anti-microbial agents.

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Antihypertensive Potency of Wild Cosmos (Cosmos caudatus Kunth, Asteraceae) Leaf Extract

Cited by 15 publications

References 20 publications

Relationship between Traditional Malaysian Vegetables (Ulam) Intake and Cognitive Status Among Middle-aged Adults from Low Cost Residential Areas

Relationship between Traditional Malaysian Vegetables (Ulam) Intake and Cognitive Status Among Middle-aged Adults from Low Cost Residential Areas

Tasty Herb that Heals: A Review of Cosmos caudatus (Ulam Raja) and its Potential Uses in Dentistry

Ultrasonic-Assisted Extraction (UAE) for Enhanced Recovery of Bioactive Phenolic Compounds From Cosmos Caudatus Leaves

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