Antihypertensive substance in seeds of L.

Inokuchi, Jin-ichi; Okabe, Hikaru; Yamauchi, Tatsuo; Nagamatsu, Akio; Nonaka, Gen‐ichiro; Nishioka, Itsuo

doi:10.1016/0024-3205(86)90470-4

Cited by 73 publications

(37 citation statements)

References 5 publications

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“…However, a comparison of monomers with the procy anidin B-2 3,3 di-O-gallate (dimer) and procyanidin C-1 3,3',3"-tri-O-gallate (trimer) suggested that the inhibition of ACE by these tannins showed a tendency to increase when they were polymerized. The inhibition of ACE by tannins proportional to their degree of polymerization was similar to that reported by Inokuchi et al (15) procyanidin B-5 3,3'-di-O-gallate was not only due to the metal chelation. The K; value was determined from a Dixon plot (Fig.…”

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confidence: 88%

Inhibitory effects of condensed tannins on angiotensin converting enzyme.

et al. 1987

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Abstract-Effects of condensed tannins isolated from Rhei Rhizoma on the activities of angiotensin converting enzyme (ACE) and various proteases were examined in vitro. Among the various condensed tannins tested, procyanidin B-5 3,3 di-O-gallate and procyanidin C-1 3,3",3"-tri-O-gallate strongly inhibited the activity of ACE. The concentration of procyanidin B-5 3,3'-di-O-gallate required for 50% inhibition of ACE was 1.3X10-6 M. The inhibition of ACE by condensed tannins was reversible and non-competitive, according to dialysis and to Dixon plots. However, over one hundred times the concentration was required to inhibit activities of other proteases such as trypsin, chymotrypsin, leucine aminopeptidase, carboxypeptidase A and urinary kallikrein. These results suggest that the inhibitory effects of condensed tannins on the activities of ACE are specific.

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supporting

confidence: 88%

Inhibitory effects of condensed tannins on angiotensin converting enzyme.

et al. 1987

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“…Oral management of these drugs regularly results in unsolicited side efects; nutritional method strength be a healthier medium by which blood pressure in skillful. Besides, some trainings obligate been made on single plant species where several classes of angiotensin I-converting enzyme inhibitory molecules must be recognized, such as lavonoids, xanthones, proanthocyanidins, secoiridoids, and peptides for a complete evaluation of natural compounds [42][43][44][45][46][47][48].…”

Section: Angiotensin-converting Enzymementioning

confidence: 99%

Natural Products as a Potential Enzyme Inhibitors from Medicinal Plants

Rauf¹,

Jehan²

2017

Enzyme Inhibitors and Activators

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Enzyme inhibitory agents are atractive because of their application in treating diferent ailments. The absence of enzymes produce a number of diseases. Medicinal plants are a rich source of producing secondary metabolites which showed broad-spectrum enzyme inhibitory potential. The position of enzyme inhibitors as new drugs is vast since these compounds have been used for the treatment of various physiological disorders. Bioactive secondary metabolites can deliver excellent pharmacophore paterns for drugs related to numerous illnesses. This book chapter is planned to document the enzyme inhibitory potential of natural compounds, medicinal plant extract, and its isolated compounds.

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“…Areca nut is popular chewable items used in traditional herbal medicine [16][17][18]. Areca nut exhibits multiple therapeutic properties like, aphrodisiac [19], antihypertensive [20,21], wound healing [22], hypoglycemic [23,24] and antidepressant [25]. It is one of the most commonly used drugs in the world, containing alkaloids, tannins, polyphenols, sugars, and lipids that have anthelmintic, antifungal, antibacterial, anti-inflammatory, and antioxidant activities [26].…”

Section: Areca Nutmentioning

confidence: 99%