Antihypertensive treatment and blood pressure control relative to hypertension treatment guidelines

Abstract

JNC7-concordance is high overall, but drops substantially when JNC7 recommendations are more demanding (e.g., among patients with stage 2 hypertension and/or CKD, CHF, diabetes). Overall, patients who are prescribed an antihypertensive regimen that is JNC7-concordant are more likely to achieve BP control.

Stage 2 hypertension: predictors of failure to achieve blood pressure control and the impact of adding one additional antihypertensive class

“…Consistent with previous research, ~50% of patients with stage 2 hypertension achieved blood pressure control . Our study also confirms and extends upon prior research by identifying predictors of failure to achieve BP control specifically for patients with stage 2 hypertension.…”

“…Risk factors for not achieving control included higher body mass index (BMI), higher baseline SBP, CKD, and diabetes. Strikingly, only 50% of patients were treated according to hypertension guidelines …”

“…Strikingly, only 50% of patients were treated according to hypertension guidelines. [12][13][14] Hypertension guidelines emphasize the importance of pharmacotherapy for stage 2 hypertension and consistently recommend at least dual-class antihypertensive therapy. 11,15 Research also supports the benefits of adding a third antihypertensive class for those who are inadequately controlled with dual-class therapy.…”

Target Organ Damage And The Long Term Effect of Nonadherence To Clinical Practice Guidelines In Patients With Hypertension: A Retrospective Cohort Study

“…The mean progression free period for discordant patients was shorter than concordant patients. A study compared treatment guidelines and BP control also stated that patients who were prescribed an antihypertensive regimen that is JNC concordant were having optimal control of BP [39]. The basic aim of adherence to standard treatment guidelines in the treatment of hypertension is to achieve adequate disease control, since controlled hypertension results delayed complications and progression of target organ damage.…”

Simultaneous determination of amlodipine and telmisartan from pharmaceutical products by way of capillary electrophoresis

“…Hypertension (also known as arterial hypertension or high blood pressure) is currently the biggest single contributor to global mortality, and extensive randomized trial data are consistent in showing that blood pressure reduction substantially reduces cardiovascular morbidity and mortality [11].…”