2019
DOI: 10.1002/gps.5250
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Antihypertensive treatment and depressive symptoms in Chinese middle‐aged and older hypertensive adults: A population‐based longitudinal study

Abstract: Objectives: Hypertension is a risk factor for depressive disorders. Although the benefits of lowering blood pressure on the subsequent depressive disorders are supported by biological interpretation, the effect of antihypertensive therapies on depressive disorders is not clear. This study aimed to assess whether blood-pressure-lowering treatment have a protective effect on subsequent depressive symptoms in China. Methods:We used data from the nationally representative survey, including 2428 hypertensive partic… Show more

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(1 citation statement)
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“… 46 Second, other blood pressure-lowering treatments, such as exercise, diet, weight control, and smoking control, have been shown to have a protective effect on subsequent depressive symptoms. 47 Third, high blood pressure can increase the levels of neurotrophic factors in the brain, which is thought to be a protective factor for depressive symptoms. 48 However, hypertension can also play an important role in the development of depressive symptoms; for example, sympathetic activation is a specific feature of essential hypertension, and may play a pathogenic role in depression.…”
Section: Discussionmentioning
confidence: 99%
“… 46 Second, other blood pressure-lowering treatments, such as exercise, diet, weight control, and smoking control, have been shown to have a protective effect on subsequent depressive symptoms. 47 Third, high blood pressure can increase the levels of neurotrophic factors in the brain, which is thought to be a protective factor for depressive symptoms. 48 However, hypertension can also play an important role in the development of depressive symptoms; for example, sympathetic activation is a specific feature of essential hypertension, and may play a pathogenic role in depression.…”
Section: Discussionmentioning
confidence: 99%