Antihyperuricemic efficacy of Scopoletin-loaded Soluplus micelles in yeast extract/potassium oxonate-induced hyperuricemic mice

Zeng, Yingchun; Ma, Yu; Yang, Zhengyu; Mao, Jiamin; Zheng, Yaxin

doi:10.1080/03639045.2020.1811302

Cited by 11 publications

(8 citation statements)

References 31 publications

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“…Scopoletin (6-methoxy-7-hydroxycoumarin), a naturally occurring phenolic coumarin isolated from medicinal herbs [21,22], has been verified to lower UA levels in hyperuricemic mice induced by potassium oxyzinate [23] or yeast extract/potassium oxyzinate [24], even if the uricase acts in parallel on hyperuricemic mice; thus, it is essential to investigate the regulation of urate transporters and XO activities in vitro. The same is true for chlorogenic acid, one of the most abundant polyphenols in herbs, whose isolation and identification methods have been extensively explored and it could be extracted from Eucommia ulmoides (Oliver) leaf [25], green coffee [26], and Eupatorium adenophorum (Spreng) [27], etc.…”

Section: Discussionmentioning

confidence: 99%

Identification of Scopoletin and Chlorogenic Acid as Potential Active Components in Sunflower Calathide Enzymatically Hydrolyzed Extract towards Hyperuricemia

Dai

et al. 2021

Applied Sciences

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It is known that sunflower (Helianthus annuus L.) calathide enzymatically hydrolyzed extract (SCHE) contributes to the regulation of serum uric acid (UA); however, evidence regarding its bioactive components and mechanism are lacking. We identified two water-soluble components (scopoletin and chlorogenic acid) that are abundant in sunflower calathide, especially evaluated for the inhibition of xanthine oxidase (XO) and the expression levels of urate transporters with SCHE. Molecular docking of a chlorogenic acid–XO complex was more stable than that of the Scopoletin–XO, and its binding pockets, which closed the Mo = S center, was similar to xanthine pockets. Moreover, chlorogenic acid exhibited stronger inhibition than that of the scopoletin below 260 μM, despite the IC50 of scopoletin (577.7 μM) being lower than that chlorogenic acid (844.7 μM) on the UA generation assessed by a spectrophotometer in vitro. It revealed that chlorogenic acid and scopoletin were competitive inhibitors of XO. In addition, the SCHE (300 μg/mL) and chlorogenic acid (0.75 mM) obviously inhibited urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) expression levels, while scopoletin significantly upregulated the expression of GLUT9. To summarize, chlorogenic acid served a crucial role in UA regulation consistent with the SCHE and functioned as an important ingredient of SCHE. The strategic analysis of SCHE combined with scopoletin and chlorogenic acid may contribute to the development of food supplemental alternatives on UA metabolism and the reduction of agricultural byproduct waste.

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Section: Discussionmentioning

confidence: 99%

Identification of Scopoletin and Chlorogenic Acid as Potential Active Components in Sunflower Calathide Enzymatically Hydrolyzed Extract towards Hyperuricemia

Dai

et al. 2021

Applied Sciences

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“…One important contributor to oxidative stress in many cell types is the xanthine oxidase (XO)/xanthine dehydrogenase (XDH) system ( 201 , 504 , 505 ). XO activity in the liver produces uric acid, which is released into circulation and excreted by the kidney.…”

Section: Effects Of Bioactive Compounds Found In a Scopariamentioning

confidence: 99%

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

et al. 2022

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Botanicals have a long history of medicinal use for a multitude of ailments, and many modern pharmaceuticals were originally isolated from plants or derived from phytochemicals. Among these, artemisinin, first isolated from Artemisia annua, is the foundation for standard anti-malarial therapies. Plants of the genus Artemisia are among the most common herbal remedies across Asia and Central Europe. The species Artemisia scoparia (SCOPA) is widely used in traditional folk medicine for various liver diseases and inflammatory conditions, as well as for infections, fever, pain, cancer, and diabetes. Modern in vivo and in vitro studies have now investigated SCOPA’s effects on these pathologies and its ability to mitigate hepatotoxicity, oxidative stress, obesity, diabetes, and other disease states. This review focuses on the effects of SCOPA that are particularly relevant to metabolic health. Indeed, in recent years, an ethanolic extract of SCOPA has been shown to enhance differentiation of cultured adipocytes and to share some properties of thiazolidinediones (TZDs), a class of insulin-sensitizing agonists of the adipogenic transcription factor PPARγ. In a mouse model of diet-induced obesity, SCOPA diet supplementation lowered fasting insulin and glucose levels, while inducing metabolically favorable changes in adipose tissue and liver. These observations are consistent with many lines of evidence from various tissues and cell types known to contribute to metabolic homeostasis, including immune cells, hepatocytes, and pancreatic beta-cells. Compounds belonging to several classes of phytochemicals have been implicated in these effects, and we provide an overview of these bioactives. The ongoing global epidemics of obesity and metabolic disease clearly require novel therapeutic approaches. While the mechanisms involved in SCOPA’s effects on metabolic, anti-inflammatory, and oxidative stress pathways are not fully characterized, current data support further investigation of this plant and its bioactives as potential therapeutic agents in obesity-related metabolic dysfunction and many other conditions.

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“…Moreover, due to the more potent modulation on the expression levels of URAT1, GLUT9 and OAT1, Sco-Ms improved the uricosuric effect of Sco. Findings indicated that Sco-Ms was a promising approach for Sco to treat hyperuricemia 25 .…”

Section: Antihyperuricemic Activity Of Scopoletinmentioning

confidence: 99%

“…Scopoletin plays a major role in treating various diseases. Scopoletin possess anti-aging 2 , acaricidal 3,4 , anti-amyloidogenic 5 , anti-angiogenic 6 , anti-anxiety 7 , anti-arthritic 8,9 , anti-bacterial 1 , anti-cancer 10,11,12,13 , anticonvulsant 14 , anticholinesterase 15 , anti-depressant 16 , anti-diabetic 17,18 , antidopaminergic-antiadrenergic 19 , anti-fungal 20, 21 , anti-hepatosteatosis-anti-obesity 22,23 , antihypertensive 24 , antihyperuricemic 25 , antiinflammatory 15,22,26,27,28 , anti-microbial1, antimigratory 12 , antioxidant 15,29,30,31 , antiproliferative 32 , anti-termite 33 , anti-thyroid 30 , antitubercular 34 , anti-tumor 6,35,36,37,38 , hepatoprotective 39 , neuroprotective 5,40,41,42 activities and it also plays an important role in esophagi...…”

mentioning

confidence: 99%

Untitled

2021

IJPSR

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Scopoletin (7-hydroxy-6-methoxy coumarin) is a phenolic coumarin isolated from many plants, known as an important compound of the phytoalexin group. This article is created to provide information regarding the synthesis and pharmacological activity of scopoletin. Scopoletin has been found in many plant species and isolated from various parts of the plant (roots, fruits, leaves, stems, etc.) such as Morinda citrifolia, Aegle marmelos, Erycibe obtusifolia Benth, Lasianthus lucidus Blume, Melia azedarach L., Sinomonium acutum, Convolvulus prostratus, and Solanum lyratum, etc. which all possess a number of medicinal properties. Its various pharmacological activities have been reported through a number of investigations. It is reported that such compounds produced specific biological activities and possible health implications for humans in food and medicine. Pharmacological activities that are established in-vivo are antithyroid, antihypertensive, anti-proliferative, anti-inflammatory, neurological, anti-dopaminergic and anti-adrenergic, antidiabetic drug, and antihyperuricemic activities. Based on in-vitro studies, scopoletin has pharmacological activities, including an antihepatotoxicity, antibacterial, antifungal, antitubercular, and antioxidant. From the assorted pharmacological activities of scopoletin, it has the potential to be further developed.INTRODUCTION: Scopoletin (7-hydroxy-6methoxy coumarin) is a phenolic coumarin isolated from many plants, known as an important compound of the phytoalexin group. It has a yellow crystalline structure with a molecular weight of 192 and a melting point of 204-206 °C. Its various biological activities have been reported through a number of investigations. Booth et al., (2004) reported that such compounds produced specific biological activities and possible health implications for humans in food and medicine.

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Antihyperuricemic efficacy of Scopoletin-loaded Soluplus micelles in yeast extract/potassium oxonate-induced hyperuricemic mice

Cited by 11 publications

References 31 publications

Identification of Scopoletin and Chlorogenic Acid as Potential Active Components in Sunflower Calathide Enzymatically Hydrolyzed Extract towards Hyperuricemia

Identification of Scopoletin and Chlorogenic Acid as Potential Active Components in Sunflower Calathide Enzymatically Hydrolyzed Extract towards Hyperuricemia

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

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