Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils

Santos, Flávia Almeida; Rao, V. S. N.

doi:10.1002/1099-1573(200006)14:4<240::aid-ptr573>3.0.co;2-x

Cited by 421 publications

(292 citation statements)

References 19 publications

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“…Furthermore, in agreement with the mechanism of action of EOCn, 1,8-cineole was found to act by a non-opioid mechanism (18). Methyleugenol (19) and a-terpineol (20) have been reported to be central and peripheral neural depressants, respectively, which raises the suspicion that they might act as antinociceptive agents.…”

supporting

confidence: 58%

“…Regarding the contribution of EOCn constituents to its antinociceptive activity, 1,8-cineole is likely to participate in the induction of this effect, since 1,8-cineole, in the 100-400 mg/kg oral dose range, has been reported to bear antinociceptive activity (18), and 35% of the EOCn weight corresponds to 1,8-cineole. Furthermore, in agreement with the mechanism of action of EOCn, 1,8-cineole was found to act by a non-opioid mechanism (18).…”

mentioning

confidence: 99%

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Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Abdon

Leal-Cardoso

Coelho‐de‐Souza

et al. 2002

Braz J Med Biol Res

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Croton nepetaefolius Baill. is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hotplate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N = 12), but decreased it in both phases at 300 mg/kg (N = 12). At 30 mg/kg, the effect of EOCn did not differ from control values in either phase of the formalin test (N = 6). Pretreatment with naloxone (5 mg/kg, ip) significantly reversed the analgesic effect of morphine (5 mg/kg, sc) on both phases, but not that of EOCn at 300 mg/kg (N = 6) on both phases of the formalin test. The data show that orally administered EOCn promotes a dose-dependent antinociceptive effect whose mechanisms remain to be elucidated.

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supporting

confidence: 58%

mentioning

confidence: 99%

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Abdon

Leal-Cardoso

Coelho‐de‐Souza

et al. 2002

Braz J Med Biol Res

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“…Thus, it could inhibit carrageenan oedema, increased capillary permeability and granuloma formation (Santos & Rao 2000). Moreover, it exhibited a steroid-like suppression of arachidonic acid metabolism and cytokine production in vitro (Juergens et al 1998a(Juergens et al , 1998b.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and gastroprotective potential of leaf essential oil of Cinnamomum glanduliferum in ethanol-induced rat experimental gastritis

Azab

Jaleel

Eldahshan

2017

Pharmaceutical Biology

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“…It is possible that the antinociceptive effect of A. katsumadai is due to its antioxidant (Lee et al, 2003) and anti-inflammatory activities (Noh, 1998;Choi et al, 2009). The seeds contain eucalyptol, a-humulene, trans,trans-farnesol(I), linalool, camphor, terpinen-4-ol, carvotanacetone, bornyl acetate, geranyl acetate, methyl cinnamate, nerolidol, alpinetin, cardamomin and diarylheptanoids (Yushiro et al, 1968;Saiki et al, 1978;Kuroyanagi et al, 1983;Brown and Rice-Evans, 1998) and it has been reported that eucalyptol and terpinen-4-ol have antinociceptive activity (Santos and Rao, 2000;Moreira et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

Choi¹,

Kim²,

Yeom³

et al. 2010

Biomolecules and Therapeutics

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-Alpinia katsumadai has been widely used in traditional Chinese and Korean medicine to treat a variety of conditions including emesis and gastric disorders such as gastric pain and distended abdomen. To investigate the antinociceptive potential and mechanism of A. katsumadai, ethanolic extracts of A. katsumadai were assayed on cyclooxygenase-2 and evaluated for analgesic activity based on phenylbenzoquinone (PBQ)-induced writhing and carrageenan-induced hyperalgesia tests. A. katsumadai extracts inhibited the cyclooxygenase-2 enzyme activity in a dose-dependent fashion at an IC50 value of 0.044 μg/ml. A. katsumadai extract (30-300 mg/kg, orally (p.o.) administered) significantly inhibited PBQ-induced writhing. This inhibition was judged not to be a false positive because a Rota-rod test revealed no difference in muscular coordination when compared to the controls. With regard to the carrageenan-induced hyperalgesia, A. katsumadai extract (30-300 mg/kg, p.o.) produced a significant, dose-dependent increase in the withdrawal response latencies. Naloxone did not reverse the analgesic effect of A. katsumadai extract in the carrageenan-induced hyperalgesia. Taken together, these results suggest that the antinociceptive activity of A. katsumadai is not related to the opioid receptor. A. katsumadai extract has remarkable, non-opioidreceptor-mediated analgesic effects on PBQ-induced writhing and carrageenan-induced hyperalgesia that occur via cyclooxygenase-2 inhibition.

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Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils

Cited by 421 publications

References 19 publications

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Anti-inflammatory and gastroprotective potential of leaf essential oil of Cinnamomum glanduliferum in ethanol-induced rat experimental gastritis

Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

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