Antiinflammatory Effects and Chemical Constituents of <i>Veronicastrum axillare</i>

Zheng, Cheng‐Jian; Deng, Xiangbing; Wu, Yu; Jiang, Yi-Ping; Zhu, Jian-Yong; Qin, Lu-Ping

doi:10.1002/ptr.5168

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…It is the major anti-inflammatory constituent of the EtOAc fraction of V. axillare . Interestingly, the anti-inflammatory effect of procumboside A seems to be stronger than that of dexamethasone which is also used as a positive drug in a previous study [7]. Nevertheless, the interactions among active compounds in the natural products are complex with potential synergistic/antagonistic effects, which attracts great interest in TCM research.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous work indicated that V. axillare significantly inhibits ethanol-induced gastric ulcers [6]. Recently, it was shown that the ethyl acetate (EtOAc) extracts of V. axillare displayed potent anti-inflammatory activity in vivo using xylene-induced mouse ear edema model [7]. Nevertheless, effects of V. axillare against ALI and potential anti-inflammatory mechanisms are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway

Wang

Yang

et al. 2016

Mediators of Inflammation

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Veronicastrum axillare is a traditional medical plant in China which is widely used in folk medicine due to its versatile biological activities, especially for its anti-inflammatory effects. However, the detailed mechanism underlying this action is not clear. Here, we studied the protective effects of V. axillare against acute lung injury (ALI), and we further explored the pharmacological mechanisms of this action. We found that pretreatment with V. axillare suppressed the release of proinflammatory cytokines in the serum of ALI mice. Histological analysis of lung tissue demonstrated that V. axillare inhibited LPS-induced lung injury, improved lung morphology, and reduced the activation of nuclear factor-κB (NF-κB) in the lungs. Furthermore, the anti-inflammatory actions of V. axillare were investigated in vitro. We observed that V. axillare suppressed the mRNA expression of interleukin-1β (IL-1β), IL-6, monocyte chemotactic protein-1 (MCP-1), cyclooxygenase-2 (COX-2), and tumor necrosis factor-α (TNF-α) in RAW264.7 cells challenged with LPS. Furthermore, pretreatment of V. axillare in vitro reduced the phosphorylation of p65 and IκB-α which is activated by LPS. In conclusion, our data firstly demonstrated that the anti-inflammatory effects of V. axillare against ALI were achieved through downregulation of the NF-κB signaling pathway, thereby reducing the production of inflammatory mediators.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway

Wang

Yang

et al. 2016

Mediators of Inflammation

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“…Veronicastrum axillare (Sieb. et Zucc) Yamazaki (Scrophulariaceae) has been widely used both alone and in conjugation with other herbs in Chinese folk medicines to treat injuries from chronic nephritis, pleural effusion, gastric ulcer, furunculosis, burns, snake bites, and other ailments [ 8 – 13 ]. Our preliminary studies showed that the water extract of V. axillare significantly reduced ethanol-induced gastric damage in a rat model and downregulation of the expression of the key factors of NF- κ B signaling pathway [ 14 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

Veronicastrum axillareAlleviates Ethanol-Induced Injury on Gastric Epithelial Cells via Downregulation of the NF-kB Signaling Pathway

Zhao

Chen

et al. 2017

Gastroenterology Research and Practice

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We used human gastric epithelial cells (GES-1) line in an ethanol-induced cell damage model to study the protective effect of Veronicastrum axillare and its modulation to NF-κB signal pathway. The goal was to probe the molecular mechanism of V. axillare decoction in the prevention of gastric ulcer and therefore provide guidance in the clinical application of V. axillare on treating injuries from chronic nephritis, pleural effusion, gastric ulcer, and other ailments. The effects of V. axillare-loaded serums on cell viability were detected by MTT assays. Enzyme-linked immunosorbent assay (ELISA) and Real-Time PCR methods were used to analyze the protein and mRNA expression of TNF-α, NF-κB, IκBα, and IKKβ. The results showed that V. axillare-loaded serum partially reversed the damaging effects of ethanol and NF-κB activator (phorbol-12-myristate-13-acetate: PMA) and increased cell viability. The protein and mRNA expressions of TNF-α, NF-κB, IκBα, and IKKβ were significantly upregulated by ethanol and PMA while they were downregulated by V. axillare-loaded serum. In summary, V. axillare-loaded serum has significantly protective effect on GES-1 against ethanol-induced injury. The protective effect was likely linked to downregulation of TNF-α based NF-κB signal pathway.

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“…Although this species is primarily found in the grasslands of the mountainous regions of southeastern China, it has also spread to Japan (Zheng et al. 2014 ). V. axillare has been used as a folk medicine named ‘Fushuicao’ to treat nephritic edema, cirrhotic ascites, venomous snakebite, and furuncles (Deng et al.…”

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confidence: 99%

Complete chloroplast genome of the medicinal herb Veronicastrum axillare (Sieb. et Zucc.) Yamazaki and the phylogenetic relationship analysis within the tribe Veroniceae

Luo

Gong

Zhou

et al. 2022

Mitochondrial DNA Part B

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Veronicastrum axillare (Sieb. et Zucc.) Yamazaki is a traditional medical plant with versatile biological activities. Here, we reported the complete chloroplast genome sequence of V. axillare with a total length of 152,691 bp, containing two IR regions of 25,765 bp each, an LSC region of 83,559 bp, and an SSC region of 17,602 bp. The genome encodes 131 genes, including 85 protein-coding genes, 37 tRNAs, eight rRNAs, and one pseudogene ( ycf1 ). The overall GC content is 38.3%, with the highest content of 43.31% in IR region. Comparative analysis revealed 4 potential hotspots among V. axillare and other Veroniceae plants, providing potential markers for population investigations in the tribe Veroniceae. A total of 56 simple sequence repeats were identified in V. axillare. Phylogenetic analysis indicated a sister relationship between V. axillare and V. sibiricum , suggesting a close genetic relationship between the two Veronicastrum species. Our results provide basic genetic resources for investigating the evolutionary status of V. axillare within the tribe Veroniceae.

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Antiinflammatory Effects and Chemical Constituents of Veronicastrum axillare

Cited by 8 publications

References 12 publications

Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway

Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway

Veronicastrum axillareAlleviates Ethanol-Induced Injury on Gastric Epithelial Cells via Downregulation of the NF-kB Signaling Pathway

Complete chloroplast genome of the medicinal herb Veronicastrum axillare (Sieb. et Zucc.) Yamazaki and the phylogenetic relationship analysis within the tribe Veroniceae

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